A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer



This article is corrected by:

  1. Errata: Corrigendum Volume 276, Issue 23, 7201, Article first published online: 6 November 2009

S. A. Waldman, 132 South 10th Street, 1170 Main, Philadelphia, PA 19107, USA
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E-mail: scott.waldman@jefferson.edu


There is emerging evidence of the production in human tumors of abnormal levels of microRNAs (miRNAs), which have been assigned oncogenic and/or tumor-suppressor functions. While some miRNAs commonly exhibit altered amounts across tumors, more often, different tumor types produce unique patterns of miRNAs, related to their tissue of origin. The role of miRNAs in tumorigenesis underscores their value as mechanism-based therapeutic targets in cancer. Similarly, unique patterns of altered levels of miRNA production provide fingerprints that may serve as molecular biomarkers for tumor diagnosis, classification, prognosis of disease-specific outcomes and prediction of therapeutic responses.