• 1
    Amaral J & Becerra SP (2008) Pigment epithelium-derived factor and angiogenesis: therapeutic implications. In Retinal and Choroidal Angiogenesis (Penn JS, ed.), pp. 311337. Springer, Dordrecht, The Netherlands.
  • 2
    Barnstable CJ & Tombran-Tink J (2004) Neuroprotective and antiangiogenic actions of PEDF in the eye: molecular targets and therapeutic potential. Prog Retin Eye Res 23, 561577.
  • 3
    Bouck N (2002) PEDF: anti-angiogenic guardian of ocular function. Trends Mol Med 8, 330334.
  • 4
    Dawson DW, Volpert OV, Gillis P, Crawford SE, Xu H, Benedict W & Bouck NP (1999) Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 285, 245248.
  • 5
    Ek ET, Dass CR & Choong PF (2006) PEDF: a potential molecular therapeutic target with multiple anti-cancer activities. Trends Mol Med 12, 497502.
  • 6
    Wu YQ & Becerra SP (1996) Proteolytic activity directed toward pigment epithelium-derived factor in vitreous of bovine eyes. Implications of proteolytic processing. Invest Ophthalmol Vis Sci 37, 19841993.
  • 7
    Wu YQ, Notario V, Chader GJ & Becerra SP (1995) Identification of pigment epithelium-derived factor in the interphotoreceptor matrix of bovine eyes. Protein Expr Purif 6, 447456.
  • 8
    Cayouette M, Smith SB, Becerra SP & Gravel C (1999) Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis 6, 523532.
  • 9
    Crawford SE, Stellmach V, Ranalli M, Huang X, Huang L, Volpert O, De Vries GH, Abramson LP & Bouck N (2001) Pigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity. J Cell Sci 114, 44214428.
  • 10
    Doll JA, Stellmach VM, Bouck NP, Bergh AR, Lee C, Abramson LP, Cornwell ML, Pins MR, Borensztajn J & Crawford SE (2003) Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas. Nat Med 9, 774780.
  • 11
    Mori K, Duh E, Gehlbach P, Ando A, Takahashi K, Pearlman J, Mori K, Yang HS, Zack DJ, Ettyreddy D et al. (2001) Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization. J Cell Physiol 188, 253263.
  • 12
    Mori K, Gehlbach P, Yamamoto S, Duh E, Zack DJ, Li Q, Berns KI, Raisler BJ, Hauswirth WW & Campochiaro PA (2002) AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci 43, 19942000.
  • 13
    Renno RZ, Youssri AI, Michaud N, Gragoudas ES & Miller JW (2002) Expression of pigment epithelium-derived factor in experimental choroidal neovascularization. Invest Ophthalmol Vis Sci 43, 15741580.
  • 14
    Spranger J, Osterhoff M, Reimann M, Mohlig M, Ristow M, Francis MK, Cristofalo V, Hammes HP, Smith G, Boulton M et al. (2001) Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease. Diabetes 50, 26412645.
  • 15
    Stellmach V, Crawford SE, Zhou W & Bouck N (2001) Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor. Proc Natl Acad Sci USA 98, 25932597.
  • 16
    Takita H, Yoneya S, Gehlbach PL, Duh EJ, Wei LL & Mori K (2003) Retinal neuroprotection against ischemic injury mediated by intraocular gene transfer of pigment epithelium-derived factor. Invest Ophthalmol Vis Sci 44, 44974504.
  • 17
    Wang L, Schmitz V, Perez-Mediavilla A, Izal I, Prieto J & Qian C (2003) Suppression of angiogenesis and tumor growth by adenoviral-mediated gene transfer of pigment epithelium-derived factor. Mol Ther 8, 7279.
  • 18
    Amaral J & Becerra SP (2010) Effects of human recombinant PEDF protein and PEDF-derived peptide 34-mer on choroidal neovascularization. Invest Ophthalmol Vis Sci 51, 13181326.
  • 19
    Notari L, Miller A, Martinez A, Amaral J, Ju M, Robinson G, Smith LE & Becerra SP (2005) Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia. Invest Ophthalmol Vis Sci 46, 27362747.
  • 20
    Becerra SP (2006) Focus on molecules: pigment epithelium-derived factor (PEDF). Exp Eye Res 82, 739740.
  • 21
    Alberdi E, Aymerich MS & Becerra SP (1999) Binding of pigment epithelium-derived factor (PEDF) to retinoblastoma cells and cerebellar granule neurons. Evidence for a PEDF receptor. J Biol Chem 274, 3160531612.
  • 22
    Aymerich MS, Alberdi EM, Martinez A & Becerra SP (2001) Evidence for pigment epithelium-derived factor receptors in the neural retina. Invest Ophthalmol Vis Sci 42, 32873293.
  • 23
    Bilak MM, Becerra SP, Vincent AM, Moss BH, Aymerich MS & Kuncl RW (2002) Identification of the neuroprotective molecular region of pigment epithelium-derived factor and its binding sites on motor neurons. J Neurosci 22, 93789386.
  • 24
    Filleur S, Volz K, Nelius T, Mirochnik Y, Huang H, Zaichuk TA, Aymerich MS, Becerra SP, Yap R, Veliceasa D et al. (2005) Two functional epitopes of pigment epithelial-derived factor block angiogenesis and induce differentiation in prostate cancer. Cancer Res 65, 51445152.
  • 25
    Notari L, Baladron V, Aroca-Aguilar JD, Balko N, Heredia R, Meyer C, Notario PM, Saravanamuthu S, Nueda ML, Sanchez-Sanchez F et al. (2006) Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor. J Biol Chem 281, 3802238037.
  • 26
    Champagne E, Martinez LO, Collet X & Barbaras R (2006) Ecto-F1Fo ATP synthase/F1 ATPase: metabolic and immunological functions. Curr Opin Lipidol 17, 279284.
  • 27
    Chi SL & Pizzo SV (2006) Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase. Cancer Res 66, 875882.
  • 28
    Raisler BJ, Berns KI, Grant MB, Beliaev D & Hauswirth WW (2002) Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1–3 of angiostatin reduce retinal neovascularization. Proc Natl Acad Sci USA 99, 89098914.
  • 29
    Wahl ML, Kenan DJ, Gonzalez-Gronow M & Pizzo SV (2005) Angiostatin’s molecular mechanism: aspects of specificity and regulation elucidated. J Cell Biochem 96, 242261.
  • 30
    Moser TL, Kenan DJ, Ashley TA, Roy JA, Goodman MD, Misra UK, Cheek DJ & Pizzo SV (2001) Endothelial cell surface F1–F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin. Proc Natl Acad Sci USA 98, 66566661.
  • 31
    Moser TL, Stack MS, Asplin I, Enghild JJ, Hojrup P, Everitt L, Hubchak S, Schnaper HW & Pizzo SV (1999) Angiostatin binds ATP synthase on the surface of human endothelial cells. Proc Natl Acad Sci USA 96, 28112816.
  • 32
    Veitonmaki N, Cao R, Wu LH, Moser TL, Li B, Pizzo SV, Zhivotovsky B & Cao Y (2004) Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for k1–5-induced antiangiogenesis. Cancer Res 64, 36793686.
  • 33
    Arakaki N, Nagao T, Niki R, Toyofuku A, Tanaka H, Kuramoto Y, Emoto Y, Shibata H, Magota K & Higuti T (2003) Possible role of cell surface H+-ATP synthase in the extracellular ATP synthesis and proliferation of human umbilical vein endothelial cells. Mol Cancer Res 1, 931939.
  • 34
    Kimura Y, Baba K & Okuda H (2000) Inhibitory effects of active substances isolated from Cassia garrettiana heartwood on tumor growth and lung metastasis in Lewis lung carcinoma-bearing mice (Part 2). Anticancer Res 20, 29232930.
  • 35
    Burwick NR, Wahl ML, Fang J, Zhong Z, Moser TL, Li B, Capaldi RA, Kenan DJ & Pizzo SV (2005) An Inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface. J Biol Chem 280, 17401745.
  • 36
    Yamagishi S, Inagaki Y, Nakamura K, Abe R, Shimizu T, Yoshimura A & Imaizumi T (2004) Pigment epithelium-derived factor inhibits TNF-alpha-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation. J Mol Cell Cardiol 37, 497506.
  • 37
    Gledhill JR, Montgomery MG, Leslie AG & Walker JE (2007) Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols. Proc Natl Acad Sci USA 104, 1363213637.
  • 38
    Stratikos E, Alberdi E, Gettins PG & Becerra SP (1996) Recombinant human pigment epithelium-derived factor (PEDF): characterization of PEDF overexpressed and secreted by eukaryotic cells. Protein Sci 5, 25752582.
  • 39
    Mueller DM, Puri N, Kabaleeswaran V, Terry C, Leslie AG & Walker JE (2004) Ni-chelate-affinity purification and crystallization of the yeast mitochondrial F1-ATPase. Protein Expr Purif 37, 479485.
  • 40
    Shao R & Guo X (2004) Human microvascular endothelial cells immortalized with human telomerase catalytic protein: a model for the study of in vitro angiogenesis. Biochem Biophys Res Commun 321, 788794.
  • 41
    Alberdi E, Hyde CC & Becerra SP (1998) Pigment epithelium-derived factor (PEDF) binds to glycosaminoglycans: analysis of the binding site. Biochemistry 37, 1064310652.
  • 42
    Meyer C, Notari L & Becerra SP (2002) Mapping the type I collagen-binding site on pigment epithelium-derived factor. Implications for its antiangiogenic activity. J Biol Chem 277, 4540045407.