• 1
    Scott JD & Pawson T (2009) Cell signaling in space and time: where proteins come together and when they’re apart. Science 326, 12201224.
  • 2
    Skalhegg BS & Tasken K (2000) Specificity in the cAMP/PKA signaling pathway. Differential expression, regulation, and subcellular localization of subunits of PKA. Front Biosci 5, D678D693.
  • 3
    Dostmann WR & Taylor SS (1991) Identifying the molecular switches that determine whether (Rp)-cAMPS functions as an antagonist or an agonist in the activation of cAMP-dependent protein kinase I. Biochemistry 30, 87108716.
  • 4
    Wong W & Scott JD (2004) AKAP signalling complexes: focal points in space and time. Nat Rev Mol Cell Biol 5, 959970.
  • 5
    Wang L, Sunahara RK, Krumins A, Perkins G, Crochiere ML, Mackey M, Bell S, Ellisman MH & Taylor SS (2001) Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein. Proc Natl Acad Sci U S A 98, 32203225.
  • 6
    Carr DW, Stofko-Hahn RE, Fraser ID, Bishop SM, Acott TS, Brennan RG & Scott JD (1991) Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif. J Biol Chem 266, 1418814192.
  • 7
    Gold MG et al. (2006) Molecular basis of AKAP specificity for PKA regulatory subunits. Mol Cell 24, 383395.
  • 8
    Kinderman FS, Kim C, von Daake S, Ma Y, Pham BQ, Spraggon G, Xuong NH, Jennings PA & Taylor SS (2006) A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Mol Cell 24, 397408.
  • 9
    Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA & Scott JD (2003) Bioinformatic design of A-kinase Anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci USA 100, 44454450.
  • 10
    Carlson CR, Lygren B, Berge T, Hoshi N, Wong W, Tasken K & Scott JD (2006) Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor. J Biol Chem 281, 2153521545.
  • 11
    Coghlan VM, Hausken ZE & Scott JD (1995) Subcellular targeting of kinases and phosphatases by association with bifunctional anchoring proteins. Biochem Soc Trans 23, 591596.
  • 12
    Klauck TM, Faux MC, Labudda K, Langeberg LK, Jaken S & Scott JD (1996) Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein. Science 271, 15891592.
  • 13
    Colledge M, Dean RA, Scott GK, Langeberg LK, Huganir RL & Scott JD (2000) Targeting of PKA to glutamate receptors through a MAGUK–AKAP complex. Neuron 27, 107119.
  • 14
    Tavalin SJ, Colledge M, Hell JW, Langeberg LK, Huganir RL & Scott JD (2002) Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression. J Neurosci 22, 30443051.
  • 15
    Hoshi N, Langeberg LK & Scott JD (2005) Distinct enzyme combinations in AKAP signalling complexes permit functional diversity. Nat Cell Biol 7, 10661073.
  • 16
    Hoshi N et al. (2003) AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Nat Neurosci 6, 564571.
  • 17
    Hoshi N, Langeberg LK, Gould CM, Newton AC & Scott JD (2010) Interaction with AKAP79 modifies the cellular pharmacology of PKC. Mol Cell 37, 541550.
  • 18
    Tunquist BJ, Hoshi N, Guire ES, Zhang F, Mullendorff K, Langeberg LK, Raber J & Scott JD (2008) Loss of AKAP150 perturbs distinct neuronal processes in mice. Proc Natl Acad Sci USA 105, 1255712562.
  • 19
    Oliveria SF, Dell’Acqua ML & Sather WA (2007) AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling. Neuron 55, 261275.
  • 20
    Davare MA, Avdonin V, Hall DD, Peden EM, Burette A, Weinberg RJ, Horne MC, Hoshi T & Hell JW (2001) A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cavl.2. Science 293, 98101.
  • 21
    Gao T, Yatani A, Dell’Acqua ML, Sako H, Green SA, Dascal N, Scott JD & Hosey MM (1997) cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits. Neuron 19, 185196.
  • 22
    De Jongh KS, Murphy BJ, Colvin AA, Hell JW, Takahashi M & Catterall WA (1996) Specific phosphorylation of a site in the full-length form of the alpha 1 subunit of the cardiac L-type calcium channel by adenosine 3′,5′-cyclic monophosphate-dependent protein kinase. Biochemistry 35, 1039210402.
  • 23
    Navedo MF, Amberg GC, Votaw VS & Santana LF (2005) Constitutively active L-type Ca2+ channels. Proc Natl Acad Sci USA 102, 1111211117.
  • 24
    Navedo MF, Nieves-Cintron M, Amberg GC, Yuan C, Votaw VS, Lederer WJ, McKnight GS & Santana LF (2008) AKAP150 is required for stuttering persistent Ca2+ sparklets and angiotensin II-induced hypertension. Circ Res 102, e1e11.
  • 25
    Dodge-Kafka KL, Langeberg L & Scott JD (2006) Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase Anchoring proteins. Circ Res 98, 9931001.
  • 26
    Dodge-Kafka KL, Soughayer J, Pare GC, Carlisle Michel JJ, Langeberg LK, Kapiloff MS & Scott JD (2005) The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature 437, 574578.
  • 27
    Carlisle Michel JJ, Dodge KL, Wong W, Mayer NC, Langeberg LK & Scott JD (2004) PKA phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signaling complex. Biochem J 381, 587592.
  • 28
    Wong W, Goehring AS, Kapiloff MS, Langeberg LK & Scott JD (2008) mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha. Sci Signal 1, 8492.
  • 29
    Diviani D (2007) Modulation of cardiac function by A-kinase anchoring proteins. Curr Opin Pharmacol 8, 166173.
  • 30
    Carnegie GK, Smith FD, McConnachie G, Langeberg LK & Scott JD (2004) AKAP–Lbc nucleates a protein kinase D activation scaffold. Mol Cell 15, 889899.
  • 31
    Diviani D, Soderling J & Scott JD (2001) AKAP–Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation. J Biol Chem 276, 4424744257.
  • 32
    Diviani D, Abuin L, Cotecchia S & Pansier L (2004) Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP–Lbc signaling complex. EMBO J 23, 28112820.
  • 33
    Jin J et al. (2004) Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol 14, 14361450.
  • 34
    Baisamy L, Jurisch N & Diviani D (2005) Leucine zipper-mediated homo-oligomerization regulates the Rho-GEF activity of AKAP–Lbc. J Biol Chem 280, 1540515412.
  • 35
    Vega RB, Harrison BC, Meadows E, Roberts CR, Papst PJ, Olson EN & McKinsey TA (2004) Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5. Mol Cell Biol 24, 83748385.
  • 36
    Carnegie GK et al. (2008) AKAP–Lbc mobilizes a cardiac hypertrophy signaling pathway. Mol Cell 32, 169179.