SEARCH

SEARCH BY CITATION

References

  • 1
    Grell M (1995) Tumor necrosis factor (TNF) receptors in cellular signaling of soluble and membrane-expressed TNF. J Inflamm 47, 817.
  • 2
    Wajant H, Pfizenmaier K & Scheurich P (2003) Tumor necrosis factor signaling. Cell Death Differ 10, 4565.
  • 3
    Hohmann HP, Remy R, Brockhaus M & van Loon AP (1989) Two different cell types have different major receptors for human tumor necrosis factor (TNF alpha). J Biol Chem 264, 1492714934.
  • 4
    Loetscher H, Pan Y-CE, Lahm H-W, Gentz R, Brockhaus M, Tabuchi H & Lesslauer W (1990) Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor. Cell 61, 351359.
  • 5
    Schall TJ, Lewis M, Koller KJ, Lee A, Rice GC, Wong GHW, Gatanaga T, Granger GA, Lentz R, Raab H et al. (1990) Molecular cloning and expression of a receptor for human tumor necrosis factor. Cell 61, 361370.
  • 6
    Smith C, Davis T, Anderson D, Solam L, Beckmann M, Jerzy R, Dower S, Cosman D & Goodwin R (1990) A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. Science 248(4958), 10191023.
  • 7
    Fiers W (1991) Tumor necrosis factor characterization at the molecular, cellular and in vivo level. FEBS Lett 285, 199212.
  • 8
    Tartaglia LA & Goeddel DV (1992) Two TNF receptors. Immunol Today 13, 151153.
  • 9
    Choi SJ, Lee K-H, Park HS, Kim S-K, Koh C-M & Park JY (2005) Differential expression, shedding, cytokine regulation and function of TNFR1 and TNFR2 in human fetal astrocytes. Yonsei Med J 46, 818826.
  • 10
    Faustman D & Davis M (2010) TNF receptor 2 pathway: drug target for autoimmune diseases. Nat Rev Drug Discov 9, 482493.
  • 11
    Gaur U & Aggarwal BB (2003) Regulation of proliferation, survival and apoptosis by members of the TNF superfamily. Biochem Pharmacol 66, 14031408.
  • 12
    Aggarwal BB (2003) Signalling pathways of the TNF superfamily: a double-edged sword. Nat Rev Immunol 3, 745756.
  • 13
    MacEwan DJ (2002) TNF receptor subtype signalling: differences and cellular consequences. Cell Signal 14, 477492.
  • 14
    Flynn JL, Goldstein MM, Chan J, Triebold KJ, Pfeffer K, Lowenstein CJ, Schrelber R, Mak TW & Bloom BR (1995) Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 2, 561572.
  • 15
    Deckert-Schluter M, Bluethmann H, Rang A, Hof H & Schluter D (1998) Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis. J Immunol 160, 34273436.
  • 16
    Loetscher H, Stueber D, Banner D, Mackay F & Lesslauer W (1993) Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors. J Biol Chem 268, 2635026357.
  • 17
    van der Poll T, Jansen PM, Van Zee KJ, Welborn MB III, de Jong I, Hack CE, Loetscher H, Lesslauer W, Lowry SF & Moldawer LL (1996) Tumor necrosis factor-alpha induces activation of coagulation and fibrinolysis in baboons through an exclusive effect on the p55 receptor. Blood 88, 922927.
  • 18
    Kim EY, Priatel JJ, Teh S-J & Teh H-S (2006) TNF receptor type 2 (p75) functions as a costimulator for antigen-driven T cell responses in vivo. J Immunol 176, 10261035.
  • 19
    Kafrouni MI, Brown GR & Thiele DL (2003) The role of TNF–TNFR2 interactions in generation of CTL responses and clearance of hepatic adenovirus infection. J Leukoc Biol 74, 564571.
  • 20
    Liu J, Zhao MQ, Xu L, Ramana CV, Declercq W, Vandenabeele P & Enelow RI (2005) Requirement for tumor necrosis factor-receptor 2 in alveolar chemokine expression depends upon the form of the ligand. Am J Respir Cell Mol Biol 33, 463469.
  • 21
    Ban L, Zhang J, Wang L, Kuhtreiber W, Burger D & Faustman DL (2008) Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism. Proc Natl Acad Sci USA 105, 1364413649.
  • 22
    Van Herreweghe F, Festjens N, Declercq W & Vandenabeele P (2010) Tumor necrosis factor-mediated cell death: to break or to burst, that’s the question. Cell Mol Life Sci 67, 15671579.
  • 23
    Fontaine V, Mohand-Said S, Hanoteau N, Fuchs C, Pfizenmaier K & Eisel U (2002) Neurodegenerative and neuroprotective effects of tumor necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. J Neurosci 22, 17.
  • 24
    Arnett HA, Mason J, Marino M, Suzuki K, Matsushima GK & Ting JPY (2001) TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat Neurosci 4, 11161122.
  • 25
    Welborn MB III, Van Zee K, Edwards PD, Pruitt JH, Kaibara A, Vauthey JN, Rogy M, Castleman WL, Lowry SF, Kenney JS et al. (1996) A human tumor necrosis factor p75 receptor agonist stimulates in vitro T cell proliferation but does not produce inflammation or shock in the baboon. J Exp Med 184, 165171.
  • 26
    The Lenercept Multiple Sclerosis Study Group & The University of British Columbia MS/MRI Analysis Group (1999) TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. Neurology 53, 457465.
  • 27
    van Oosten BW, Barkhof F, Truyen L, Boringa JB, Bertelsmann FW, von Blomberg BM, Woody JN, Hartung HP & Polman CH (1996) Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2. Neurology 47, 15311534.
  • 28
    Hamid T, Gu Y, Ortines RV, Bhattacharya C, Wang G, Xuan Y-T & Prabhu SD (2009) Divergent tumor necrosis factor receptor-related remodeling responses in heart failure: role of nuclear factor-kappaB and inflammatory activation. Circulation 119, 13861397.
  • 29
    Grell M, Douni E, Wajant H, Löhden M, Clauss M, Maxeiner B, Georgopoulos S, Lesslauer W, Kollias G, Pfizenmaier K et al. (1995) The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell 83, 793802.
  • 30
    Tuma R, Russell M, Rosendahl M & Thomas GJ (1995) Solution conformation of the extracellular domain of the human tumor necrosis factor receptor probed by Raman and UV-resonance Raman spectroscopy: structural effects of an engineered PEG linker. Biochemistry 34, 1515015156.
  • 31
    Chan FK-M, Chun HJ, Zheng L, Siegel RM, Bui KL & Lenardo MJ (2000) A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 288(5475), 23512354.
  • 32
    Tartaglia LA, Ayres TM, Wong GHW & Goeddel DV (1993) A novel domain within the 55 kd TNF receptor signals cell death. Cell 74, 845853.
  • 33
    Jiang Y, Woronicz JD, Liu W & Goeddel DV (1999) Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. Science 283(5401), 543546.
  • 34
    Boldin MP, Goncharov TM, Goltseve YV & Wallach D (1996) Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor induced cell death. Cell 85, 803815.
  • 35
    Hsu H, Huang J, Shu H-B, Baichwal V & Goeddel DV (1996) TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4, 387396.
  • 36
    Ting AT, Pimentel-Muinos FX & Seed B (1996) RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis. EMBO J 15, 61896196.
  • 37
    Chen N-J, Chio IIC, Lin W-J, Duncan G, Chau H, Katz D, Huang H-L, Pike KA, Hao Z, Su Y-W et al. (2008) Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors. Proc Natl Acad Sci USA 105, 1242912434.
  • 38
    Micheau O & Tschopp J (2003) Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114, 181190.
  • 39
    Lee TH, Shank J, Cusson N & Kelliher MA (2004) The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2. J Biol Chem 279, 3318533191.
  • 40
    Mahoney DJ, Cheung HH, Mrad RL, Plenchette S, Simard C, Enwere E, Arora V, Mak TW, Lacasse EC, Waring J et al. (2008) Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation. Proc Natl Acad Sci USA 105, 1177811783.
  • 41
    Varfolomeev E, Goncharov T, Fedorova AV, Dynek JN, Zobel K, Deshayes K, Fairbrother WJ & Vucic D (2008) c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation. J Biol Chem 283, 2429524299.
  • 42
    Wajant H & Scheurich P (2011) TNFR1-induced activation of the classical NF-κB pathway. FEBS J doi: 10.1111/j.1742-4658.2011.08015.x.
  • 43
    Ea C-K, Deng L, Xia Z-P, Pineda G & Chen ZJ (2006) Activation of IKK by TNFα requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell 22, 245257.
  • 44
    Wu C-J, Conze DB, Li T, Srinivasula SM & Ashwell JD (2006) Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation. Nat Cell Biol 8, 398406.
  • 45
    Blonska M, Shambharkar PB, Kobayashi M, Zhang D, Sakurai H, Su B & Lin X (2005) TAK1 is recruited to the tumor necrosis factor-α (TNF-α) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-κB activation. J Biol Chem 280, 4305643063.
  • 46
    Israel A (2006) NF-kappaB activation: nondegradative ubiquitination implicates NEMO. Trends Immunol 27, 395397.
  • 47
    Wang C-Y, Mayo MW, Korneluk RG, Goeddel DV & Baldwin AS Jr (1998) NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281, 16801683.
  • 48
    Schneider-Brachert W, Tchikov V, Neumeyer J, Jakob M, Winoto-Morbach S, Held-Feindt J, Heinrich M, Merkel O, Ehrenschwender M, Adam D et al. (2004) Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles. Immunity 21, 415428.
  • 49
    Yeh WC, Pompa JL, McCurrach ME, Shu HB, Elia AJ, Shahinian A, Ng M, Wakeham A, Khoo W, Mitchell K, El-Deiry WS et al. (1998) FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science 279, 19541958.
  • 50
    O’Donnell MA & Ting AT (2011) RIP1 comes back to life as a cell death regulator in TNFR1signaling. FEBS J doi: 10.1111/j.1742-4658.2011.08016.x.
  • 51
    Liu Z-G, Hsu H, Goeddel DV & Karin M (1996) Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87, 565576.
  • 52
    Muppidi JR, Tschopp J & Siegel RM (2004) Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction. Immunity 21, 461465.
  • 53
    Rothe M, Pan M-G, Henzel WJ, Ayres TM & Goeddel DV (1995) The TNFR2–TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 83, 12431252.
  • 54
    Thommesen L & Laegreid A (2005) Distinct differences between TNF receptor 1- and TNF receptor 2-mediated activation of NFkappaB. J Biochem Mol Biol 38, 281289.
  • 55
    Rauert H, Wicovsky A, Müller N, Siegmund D, Spindler V, Waschke J, Kneitz C & Wajant H (2010) Membrane tumor necrosis factor (TNF) induces p100 processing via TNF receptor-2 (TNFR2). J Biol Chem 285, 73947404.
  • 56
    Marchetti L, Klein M, Schlett K, Pfizenmaier K & Eisel ULM (2004) Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-d-aspartate receptor activation: essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-κB pathway. J Biol Chem 279, 3286932881.
  • 57
    Rothe M, Wong SC, Henzel WJ & Goeddel DV (1994) A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell 78, 681692.
  • 58
    Rothe M, Sarma V, Dixit VM & Goeddel DV (1995) TRAF2-mediated activation of NF-κB by TNF receptor 2 and CD40. Science 269 5229, 14241427.
  • 59
    Sun S-C & Ley SC (2008) New insights into NF-kappaB regulation and function. Trends Immunol 29, 469478.
  • 60
    Al-Lamki RS, Wang J, Vandenabeele P, Bradley JA, Thiru S, Luo D, Min W, Pober JS & Bradley JR (2005) TNFR1- and TNFR2-mediated signaling pathways in human kidney are cell type-specific and differentially contribute to renal injury. FASEB J 19, 16371645.
  • 61
    Gustin JA, Ozes ON, Akca H, Pincheira R, Mayo LD, Li Q, Guzman JR, Korgaonkar CK & Donner DB (2004) Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappaB activation. J Biol Chem 279, 16151620.
  • 62
    Eisel ULM, Biber K & Luiten PGM (2006) Life and death of nerve cells: therapeutic cytokine signaling pathways. Curr Signal Transduct Ther 1, 133146.
  • 63
    Bigda J, Beletsky I, Brakebusch C, Varfolomeev Y, Engelmann H, Holtmann H & Wallach D (1994) Dual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity. J Exp Med 180, 445460.
  • 64
    Medvedev AE, Sundan A & Espevik T (1994) Involvement of the tumor necrosis factor receptor p75 in mediating cytotoxicity and gene regulating activities. Eur J Immunol 24, 28422849.
  • 65
    Wajant H, Henkler F & Scheurich P (2001) The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators. Cell Signal 13, 389400.
  • 66
    Fotin-Mleczek M, Henkler F, Samel D, Reichwein M, Hausser A, Parmryd I, Scheurich P, Schmid JA & Wajant H (2002) Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8. J Cell Sci 115, 27572770.
  • 67
    Roy N, Deveraux QL, Takahashi R, Salvesen GS & Reed JC (1997) The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J 16, 69146925.
  • 68
    Chan FK-M & Lenardo MJ (2000) A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes. Eur J Immunol 30, 652660.
  • 69
    Li X, Yang Y & Ashwell JD (2002) TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature 416 6878, 345347.
  • 70
    Wu CJ, Conze DB, Li X, Ying SX, Hanover JA & Ashwell JD (2005) TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination. EMBO J 24, 18861898.
  • 71
    Wicovsky A, Henkler F, Salzmann S, Scheurich P, Kneitz C & Wajant H (2009) Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1–TNFR2 cooperation. Oncogene 28, 17691781.
  • 72
    Schwenzer R, Siemienski K, Liptay S, Schubert G, Peters N, Scheurich P, Schmid RM & Wajant H (1999) The human tumor necrosis factor (TNF) receptor-associated factor 1 gene (TRAF1) is up-regulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-κB and c-Jun N-terminal kinase. J Biol Chem 274, 1936819374.
  • 73
    Carpentier I & Beyaert R (1999) TRAF1 is a TNF inducible regulator of NF-kappaB activation. FEBS Lett 460, 246250.
  • 74
    Tsitsikov EN, Laouini D, Dunn IF, Sannikova TY, Davidson L, Alt FW & Geha RS (2001) TRAF1 is a negative regulator of TNF signaling: enhanced TNF signaling in TRAF1-deficient mice. Immunity 15, 647657.
  • 75
    Arron JR, Pewzner-Jung Y, Walsh MC, Kobayashi T & Choi Y (2002) Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling. J Exp Med 196, 923934.
  • 76
    Speiser DE, Lee SY, Wong B, Arron J, Santana A, Kong Y-Y, Ohashi PS & Choi Y (1997) A regulatory role for TRAF1 in antigen-induced apoptosis of T cells. J Exp Med 185, 17771783.
  • 77
    Bradley JR & Pober JS (2001) Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene 20, 6482.
  • 78
    Kalb A, Bluethmann H, Moore MW & Lesslauer W (1996) Tumor necrosis factor receptors (Tnfr) in mouse fibroblasts deficient in Tnfr1 or Tnfr2 are signaling competent and activate the mitogen-activated protein kinase pathway with differential kinetics. J Biol Chem 271, 28097280104.
  • 79
    Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K & Ichijo H (1998) ASK1 is essential for JNK/SAPK activation by TRAF2. Mol Cell 2, 389395.
  • 80
    Zhao Y, Conze DB, Hanover JA & Ashwell JD (2007) Tumor necrosis factor receptor 2 signaling induces selective c-IAP1-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signaling. J Biol Chem 282, 77777782.
  • 81
    Yamada K, Iida R, Miyamoto Y, Saito K, Sekikawa K, Seishima M & Nabeshima T (2000) Neurobehavioral alterations in mice with a targeted deletion of the tumor necrosis factor-alpha gene: implications for emotional behavior. J Neuroimmunol 111, 131138.
  • 82
    Bradham CA, Plumpe J, Manns MP, Brenner DA & Trautwein C (1998) Mechanisms of hepatic toxicity. I. TNF-induced liver injury. Am J Physiol Gastrointest Liver Physiol 275, G387G392.
  • 83
    Willuweit A, Sass G, Schoneberg A, Eisel U, Tiegs G & Clauss M (2001) Chronic inflammation and protection from acute hepatitis in transgenic mice expressing TNF in endothelial cells. J Immunol 167, 39443952.
  • 84
    Baune BT, Wiede F, Braun A, Golledge J, Arolt V & Koerner H (2008) Cognitive dysfunction in mice deficient for TNF-α and its receptors. Am J Med Genet 147B, 10561064.