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References

  • 1
    de Bold AJ, Borenstein HB, Veress AT & Sonnenberg H (1981) A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci 28, 8994.
  • 2
    de Bold AJ (1985) Atrial natriuretic factor: a hormone produced by the heart. Science 230, 767770.
  • 3
    Brenner BM, Ballermann BJ, Gunning ME & Zeidel ML (1990) Diverse biological actions of atrial natriuretic peptide. Physiol Rev 70, 665699.
  • 4
    Levin ER, Gardner DG & Samson WK (1998) Natriuretic peptides. N Engl J Med 339, 321328.
  • 5
    Pandey KN (2005) Biology of natriuretic peptides and their receptors. Peptides 26, 901932.
  • 6
    Garbers DL, Chrisman TD, Wiegn P, Katafuchi T, Albanesi JP, Bielinski V, Barylko B, Redfield MM & Burnett JC Jr (2006) Membrane guanylyl cyclase receptors: an update. Trends Endocrinol Metab 17, 251258.
  • 7
    Pandey KN (2008) Emerging roles of antriuretic peptides and their receptors in pathophysiology of hypertension and cardiovascular regulation. J Am Soc Hypertens 2, 210226.
  • 8
    Gardner DG (2003) Natriuretic peptides: markers or modulators of cardiac hypertrophy? Trends Endocrinol Metab 14, 411416.
  • 9
    Richards AM (2007) Natriuretic peptides: update on peptide release, bioactivity, and clinical use. Hypertension 50, 2530.
  • 10
    Vasan RS, Benjamin EJ, Larson MG, Leip EP, Wang TJ, Wilson PW & Levy D (2002) Plasma natriuretic peptides for community screening for left ventricular hypertrophy and systolic dysfunction: the Framingham heart study. JAMA 288, 12521259.
  • 11
    Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP & Waldman SA (2000) Guanylyl cyclases and signaling by cyclic GMP. Pharmacol Rev 52, 375414.
  • 12
    Tremblay J, Desjardins R, Hum D, Gutkowska J & Hamet P (2002) Biochemistry and physiology of the natriuretic peptide receptor guanylyl cyclases. Mol Cell Biochem 230, 3147.
  • 13
    Drewett JG & Garbers DL (1994) The family of guanylyl cyclase receptors and their ligands. Endocr Rev 15, 135162.
  • 14
    McGrath MF & de Bold AJ (2005) Determinants of natriuretic peptide gene expression. Peptides 26, 933943.
  • 15
    Rosenzweig A & Seidman CE (1991) Atrial natriuretic factor and related peptide hormones. Annu Rev Biochem 60, 229255.
  • 16
    Yan W, Wu F, Morser J & Wu Q (2000) Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme. Proc Natl Acad Sci USA 97, 85258529.
  • 17
    Thibault G, Amiri F & Garcia R (1999) Regulation of natriuretic peptide secretion by the heart. Annu Rev Physiol 61, 193217.
  • 18
    Sudoh T, Minamino N, Kangawa K & Matsuo H (1988) Brain natriuretic peptide-32: N-terminal six amino acid extended form of brain natriuretic peptide identified in porcine brain. Biochem Biophys Res Commun 155, 726732.
  • 19
    Seilhamer JJ, Arfsten A, Miller JA, Lundquist P, Scarborough RM, Lewicki JA & Porter JG (1989) Human and canine gene homologs of porcine brain natriuretic peptide. Biochem Biophys Res Commun 165, 650658.
  • 20
    Mukoyama M, Nakao K, Hosoda K, Suga S, Saito Y, Ogawa Y, Shirakami G, Jougasaki M, Obata K, Yasue H et al. (1991) Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide. J Clin Invest 87, 14021412.
  • 21
    Vellaichamy E, Khurana ML, Fink J & Pandey KN (2005) Involvement of the NF-kappa B/matrix metalloproteinase pathway in cardiac fibrosis of mice lacking guanylyl cyclase/natriuretic peptide receptor A. J Biol Chem 280, 1923019242.
  • 22
    Grepin C, Dagnino L, Robitaille L, Haberstroh L, Antakly T & Nemer M (1994) A hormone-encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription. Mol Cell Biol 14, 31153129.
  • 23
    Thuerauf DJ, Hanford DS & Glembotski CC (1994) Regulation of rat brain natriuretic peptide transcription. A potential role for GATA-related transcription factors in myocardial cell gene expression. J Biol Chem 269, 1777217775.
  • 24
    Cameron V, Aitken G, Ellmers L, Kennedy M & Espiner E (1996) The sites of gene expression of atrial, brain, and C-type natriuretic peptides in mouse fetal development: temporal changes in embryos and placenta. Endocrinology 137, 817824.
  • 25
    Ogawa Y, Nakao K, Nakagawa O, Komatsu Y, Hosoda K, Suga S, Arai H, Nagata K, Yoshida N & Imura H (1992) Human C-type natriuretic peptide. Characterization of the gene and peptide. Hypertension 19, 809813.
  • 26
    Suga S, Nakao K, Itoh H, Komatsu Y, Ogawa Y, Hama N & Imura H (1992) Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-beta: possible existence of vascular natriuretic peptide system. J Clin Invest 90, 11451149.
  • 27
    Hagiwara H, Sakaguchi H, Itakura M, Yoshimoto T, Furuya M, Tanaka S & Hirose S (1994) Autocrine regulation of rat chondrocyte proliferation by natriuretic peptide C and its receptor, natriuretic peptide receptor-B. J Biol Chem 269, 1072910733.
  • 28
    Wu C, Wu F, Pan J, Morser J & Wu Q (2003) Furin-mediated processing of Pro-C-type natriuretic peptide. J Biol Chem 278, 2584725852.
  • 29
    Schulz-Knappe P, Forssmann K, Herbst F, Hock D, Pipkorn R & Forssmann WD (1988) Isolation and structural analysis of urodilatin, a new peptide of the cardiodilatin (ANP)-family extracted from human urine. Klin Wochenschr 66, 752759.
  • 30
    Feller SM, Mägert HJ, Schulz-Knappe P & Forssmann WG (1990) Urodilatin (hANF 95-126) – characteristics of a new atrial natriuretic factor peptide. In Atrial Natriuretic Factor (Struthers AD ed.), pp. 209226. Blackwell, Oxford.
  • 31
    Saxenhofer H, Roselli A, Weidmann P, Forssmann WG, Bub A, Ferrari P & Shaw SG (1990) Urodilatin, a natriuretic factor from kidneys can modify renal and cardiovascular function in men. Am J Physiol 259, F832F838.
  • 32
    Schweitz H, Vigne P, Moinier D, Frelin CH & Lazdunski M (1992) A new member of the natriuretic peptide family is present in the venom of the green mamba (Dendroaspis angusticeps). J Biol Chem 267, 1392813932.
  • 33
    Chinkers M, Garbers DL, Chang MS, Lowe DG, Chin HM, Goeddel DV & Schulz S (1989) A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor. Nature 338, 7883.
  • 34
    Schulz S, Singh S, Bellet RA, Singh G, Tubb DJ, Chin H & Garbers DL (1989) The primary structure of a plasma membrane guanylate cyclase demonstrates diversity within this new receptor family. Cell 58, 11551162.
  • 35
    Chang MS, Lowe DG, Lewis M, Hellmiss R, Chen E & Goeddel DV (1989) Differential activation by atrial and brain natriuretic peptides of two different receptor guanylate cyclases. Nature 341, 6872.
  • 36
    Pandey KN & Singh S (1990) Molecular cloning and expression of murine guanylate cyclase/atrial natriuretic factor receptor cDNA. J Biol Chem 265, 1234212348.
  • 37
    Garbers DL (1992) Guanylyl cyclase receptors and their endocrine, paracrine, and autocrine ligands. Cell 71, 14.
  • 38
    Koller KJ, de Sauvage FJ, Lowe DG & Goeddel DV (1992) Conservation of the kinaselike regulatory domain is essential for activation of the natriuretic peptide receptor guanylyl cyclases. Mol Cell Biol 12, 25812590.
  • 39
    Khurana ML & Pandey KN (1993) Receptor-mediated stimulatory effect of atrial natriuretic factor, brain natriuretic peptide, and C-type natriuretic peptide on testosterone production in purified mouse Leydig cells: activation of cholesterol side-chain cleavage enzyme. Endocrinology 133, 21412149.
  • 40
    Fuller F, Porter JG, Arfsten AE, Miller J, Schilling JW, Scarborough RM, Lewicki JA & Schenk DB (1988) Atrial natriuretic peptide clearance receptor. Complete sequence and functional expression of cDNA clones. J Biol Chem 263, 93959401.
  • 41
    Koller KJ, Lowe DG, Bennett GL, Minamino N, Kangawa K, Matsuo H & Goeddel DV (1991) Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). Science 252, 120123.
  • 42
    Misono KS (2000) Atrial natriuretic factor binding to its receptor is dependent on chloride concentration: a possible feedback-control mechanism in renal salt regulation. Circ Res 86, 11351139.
  • 43
    Schulz S (2005) C-type natriuretic peptide and guanylyl cyclase B receptor. Peptides 26, 10241034.
  • 44
    Fulle HJ, Vassar R, Foster DC, Yang RB, Axel R & Garbers DL (1995) A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons. Proc Natl Acad Sci USA 92, 35713575.
  • 45
    Yang RB, Foster DC, Garbers DL & Fulle HJ (1995) Two membrane forms of guanylyl cyclase found in the eye. Proc Natl Acad Sci USA 92, 602606.
  • 46
    Yu S, Avery L, Baude E & Garbers DL (1997) Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory receptors. Proc Natl Acad Sci USA 94, 33843387.
  • 47
    Goraczniak RM, Duda T, Sitaramayya A & Sharma RK (1994) Structural and functional characterization of the rod outer segment membrane guanylate cyclase. Biochem J 302 (Pt 2), 455461.
  • 48
    Baude EJ, Arora VK, Yu S, Garbers DL & Wedel BJ (1997) The cloning of a Caenorhabditis elegans guanylyl cyclase and the construction of a ligand-sensitive mammalian/nematode chimeric receptor. J Biol Chem 272, 1603516039.
  • 49
    Hunter T (1995) Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 80, 225236.
  • 50
    Pandey KN & Kanungo J (1993) Expression of extracellular ligand-binding domain of murine guanylate cyclase/atrial natriuretic factor receptor cDNA in Escherichia coli. Biochem Biophys Res Commun 190, 724731.
  • 51
    Pandey KN, Kumar R, Li M & Nguyen H (2000) Functional domains and expression of truncated atrial natriuretic peptide receptor-A: the carboxyl-terminal regions direct the receptor internalization and sequestration in COS-7 cells. Mol Pharmacol 57, 259267.
  • 52
    Liu Y, Ruoho AE, Rao VD & Hurley JH (1997) Catalytic mechanism of the adenylyl and guanylyl cyclases: modeling and mutational analysis. Proc Natl Acad Sci USA 94, 1341413419.
  • 53
    Zhang G, Liu Y, Ruoho AE & Hurley JH (1997) Structure of the adenylyl cyclase catalytic core. Nature 386, 247253.
  • 54
    Sunahara RK, Beuve A, Tesmer JJ, Sprang SR, Garbers DL & Gilman AG (1998) Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases. J Biol Chem 273, 1633216338.
  • 55
    Tucker CL, Hurley JH, Miller TR & Hurley JB (1998) Two amino acid substitutions convert a guanylyl cyclase, RetGC-1, into an adenylyl cyclase. Proc Natl Acad Sci USA 95, 59935997.
  • 56
    Misono KS, Philo JS, Arakawa T, Ogata CM, Qiu Y, Ogawa H & Young HS (2011) Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase. FEBS J 278, 18181829.
  • 57
    van den Akker F, Zhang X, Miyagi M, Huo X, Misono KS & Yee VC (2000) Structure of the dimerized hormone-binding domain of a guanylyl-cyclase-coupled receptor. Nature 406, 101104.
  • 58
    Misono KS, Ogawa H, Qiu Y & Ogata CM (2005) Structural studies of the natriuretic peptide receptor: a novel hormone-induced rotation mechanism for transmembrane signal transduction. Peptides 26, 957968.
  • 59
    De Lean A, McNicoll N & Labrecque J (2003) Natriuretic peptide receptor A activation stabilizes a membrane-distal dimer interface. J Biol Chem 278, 1115911166.
  • 60
    Anand-Srivastava MB & Trachte GJ (1993) Atrial natriuretic factor receptors and signal transduction mechanisms. Pharmacol Rev 45, 455497.
  • 61
    Pandey KN (1992) Kinetic analysis of internalization, recycling and redistribution of atrial natriuretic factor–receptor complex in cultured vascular smooth-muscle cells. Ligand-dependent receptor down-regulation. Biochem J 288 (Pt 1), 5561.
  • 62
    Anand-Srivastava MB (2005) Natriuretic peptide receptor-C signaling and regulation. Peptides 26, 10441059.
  • 63
    Pandey KN, Pavlou SN & Inagami T (1988) Identification and characterization of three distinct atrial natriuretic factor receptors. Evidence for tissue-specific heterogeneity of receptor subtypes in vascular smooth muscle, kidney tubular epithelium, and Leydig tumor cells by ligand binding, photoaffinity labeling, and tryptic proteolysis. J Biol Chem 263, 1340613413.
  • 64
    Pandey KN, Nguyen HT, Sharma GD, Shi SJ & Kriegel AM (2002) Ligand-regulated internalization, trafficking, and down-regulation of guanylyl cyclase/atrial natriuretic peptide receptor-A in human embryonic kidney 293 cells. J Biol Chem 277, 46184627.
  • 65
    Burczynska B, Duda T & Sharma RK (2007) ATP signaling site in the ARM domain of atrial natriuretic factor receptor guanylate cyclase. Mol Cell Biochem 301, 93107.
  • 66
    Garbers DL & Lowe DG (1994) Guanylyl cyclase receptors. J Biol Chem 269, 3074130744.
  • 67
    Sharma RK (2010) Membrane guanylate cyclase is a beautiful signal transduction machine: overview. Mol Cell Biochem 334, 336.
  • 68
    Kurose H, Inagami T & Ui M (1987) Participation of adenosine 5′-triphosphate in the activation of membrane-bound guanylate cyclase by the atrial natriuretic factor. FEBS Lett 219, 375379.
  • 69
    Sharma RK (2002) Evolution of the membrane guanylate cyclase transduction system. Mol Cell Biochem 230, 330.
  • 70
    Chinkers M & Garbers DL (1989) The protein kinase domain of the ANP receptor is required for signaling. Science 245, 13921394.
  • 71
    Foster DC & Garbers DL (1998) Dual role for adenine nucleotides in the regulation of the atrial natriuretic peptide receptor, guanylyl cyclase-A. J Biol Chem 273, 1631116318.
  • 72
    Duda T, Goraczniak RM & Sharma RK (1993) Core sequence of ATP regulatory module in receptor guanylate cyclases. FEBS Lett 315, 143148.
  • 73
    Potter LR & Garbers DL (1994) Protein kinase C-dependent desensitization of the atrial natriuretic peptide receptor is mediated by dephosphorylation. J Biol Chem 269, 1463614642.
  • 74
    Kurose H & Lefkowitz RJ (1994) Differential desensitization and phosphorylation of three cloned and transfected alpha 2-adrenergic receptor subtypes. J Biol Chem 269, 1009310099.
  • 75
    Langlet C, Langer I, Vertongen P, Gaspard N, Vanderwinden JM & Robberecht P (2005) Contribution of the carboxyl terminus of the VPAC1 receptor to agonist-induced receptor phosphorylation, internalization, and recycling. J Biol Chem 280, 2803428043.
  • 76
    Huganir RL & Greengard P (1990) Regulation of neurotransmitter receptor desensitization by protein phosphorylation. Neuron 5, 555567.
  • 77
    Ballermann BJ, Marala RB & Sharma RK (1988) Characterization and regulation by protein kinase C of renal glomerular atrial natriuretic peptide receptor-coupled guanylate cyclase. Biochem Biophys Res Commun 157, 755761.
  • 78
    Duda T & Sharma RK (1990) Regulation of guanylate cyclase activity by atrial natriuretic factor and protein kinase C. Mol Cell Biochem 93, 179184.
  • 79
    Larose L, Rondeau JJ, Ong H & De Lean A (1992) Phosphorylation of atrial natriuretic factor R1 receptor by serine/threonine protein kinases: evidence for receptor regulation. Mol Cell Biochem 115, 203211.
  • 80
    Pandey KN (1989) Stimulation of protein phosphorylation by atrial natriuretic factor in plasma membranes of bovine adrenal cortical cells. Biochem Biophys Res Commun 163, 988994.
  • 81
    Barak LS, Tiberi M, Freedman NJ, Kwatra MM, Lefkowitz RJ & Caron MG (1994) A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration. J Biol Chem 269, 27902795.
  • 82
    Pandey KN, Nguyen HT, Garg R, Khurana ML & Fink J (2005) Internalization and trafficking of guanylyl (guanylate) cyclase/natriuretic peptide receptor A is regulated by an acidic tyrosine-based cytoplasmic motif GDAY. Biochem J 388, 103113.
  • 83
    Pandey KN (2009) Functional roles of short sequence motifs in the endocytosis of membrane receptors. Front Biosci 14, 53395360.
  • 84
    Nuglozeh E, Mbikay M, Stewart DJ & Legault L (1997) Rat natriuretic peptide receptor genes are regulated by glucocorticoids in vitro. Life Sci 61, 21432155.
  • 85
    Fujio N, Gossard F, Bayard F & Tremblay J (1994) Regulation of natriuretic peptide receptor A and B expression by transforming growth factor-beta 1 in cultured aortic smooth muscle cells. Hypertension 23, 908913.
  • 86
    Gutkowska J, Jankowski M, Sairam MR, Fujio N, Reis AM, Mukaddam-Daher S & Tremblay J (1999) Hormonal regulation of natriuretic peptide system during induced ovarian follicular development in the rat. Biol Reprod 61, 162170.
  • 87
    Arise KK & Pandey KN (2006) Inhibition and down-regulation of gene transcription and guanylyl cyclase activity of NPRA by angiotensin II involving protein kinase C. Biochem Biophys Res Commun 349, 131135.
  • 88
    Garg R & Pandey KN (2003) Angiotensin II-mediated negative regulation of Npr1 promoter activity and gene transcription. Hypertension 41, 730736.
  • 89
    Kumar P, Bolden G, Arise KK, Krazit ST & Pandey KN (2009) Regulation of natriuretic peptide receptor-A gene expression and stimulation of its guanylate cyclase activity by transcription factor Ets-1. Biosci Rep 29, 5770.
  • 90
    Kumar P & Pandey KN (2009) Cooperative activation of Npr1 gene transcription and expression by interaction of Ets-1 and p300. Hypertension 54, 172178.
  • 91
    Haneda M, Kikkawa R, Maeda S, Togawa M, Koya D, Horide N, Kajiwara N & Shigeta Y (1991) Dual mechanism of angiotensin II inhibits ANP-induced mesangial cGMP accumulation. Kidney Int 40, 188194.
  • 92
    Bottari SP, King IN, Reichlin S, Dahlstroem I, Lydon N & de Gasparo M (1992) The angiotensin AT2 receptor stimulates protein tyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclase. Biochem Biophys Res Commun 183, 206211.
  • 93
    Liang F, Schaufele F & Gardner DG (2001) Functional interaction of NF-Y and Sp1 is required for type a natriuretic peptide receptor gene transcription. J Biol Chem 276, 15161522.
  • 94
    Pandey KN (2010) Ligand-mediated endocytosis and intracellular sequestration of guanylyl cyclase/natriuretic peptide receptors: role of GDAY motif. Mol Cell Biochem 334, 8198.
  • 95
    Rathinavelu A & Isom GE (1991) Differential internalization and processing of atrial-natriuretic-factor B and C receptor in PC12 cells. Biochem J 276 (Pt 2), 493497.
  • 96
    Pandey KN, Inagami T & Misono KS (1986) Atrial natriuretic factor receptor on cultured Leydig tumor cells: ligand binding and photoaffinity labeling. Biochemistry 25, 84678472.
  • 97
    Pandey KN (1993) Stoichiometric analysis of internalization, recycling, and redistribution of photoaffinity-labeled guanylate cyclase/atrial natriuretic factor receptors in cultured murine Leydig tumor cells. J Biol Chem 268, 43824390.
  • 98
    Pandey KN (2001) Dynamics of internalization and sequestration of guanylyl cyclase/atrial natriuretic peptide receptor-A. Can J Physiol Pharmacol 79, 631639.
  • 99
    Pandey KN (2002) Intracellular trafficking and metabolic turnover of ligand-bound guanylyl cyclase/atrial natriuretic peptide receptor-A into subcellular compartments. Mol Cell Biochem 230, 6172.
  • 100
    Pandey KN (2005) Internalization and trafficking of guanylyl cyclase/natriuretic peptide receptor-A. Peptides 26, 9851000.
  • 101
    Potter LR (2011) Natriuretic peptide metabolism, clearance, and degradation. FEBS J 278, 18081817.
  • 102
    Brackmann M, Schuchmann S, Anand R & Braunewell KH (2005) Neuronal Ca2+ sensor protein VILIP-1 affects cGMP signalling of guanylyl cyclase B by regulating clathrin-dependent receptor recycling in hippocampal neurons. J Cell Sci 118, 24952505.
  • 103
    Somanna NK, Arise KK & Pandey KN (2007) Analysis of natriuretic peptide receptor A internalization by ribonucleic acid interference. J Am Investig Med 55, S262.
  • 104
    Oliver PM, Fox JE, Kim R, Rockman HA, Kim HS, Reddick RL, Pandey KN, Milgram SL, Smithies O & Maeda N (1997) Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc Natl Acad Sci USA 94, 1473014735.
  • 105
    Shi SJ, Vellaichamy E, Chin SY, Smithies O, Navar LG & Pandey KN (2003) Natriuretic peptide receptor A mediates renal sodium excretory responses to blood volume expansion. Am J Physiol Renal Physiol 285, F694F702.
  • 106
    Pandey KN, Oliver PM, Maeda N & Smithies O (1999) Hypertension associated with decreased testosterone levels in natriuretic peptide receptor-A gene-knockout and gene-duplicated mutant mouse models. Endocrinology 140, 51125119.
  • 107
    John SW, Krege JH, Oliver PM, Hagaman JR, Hodgin JB, Pang SC, Flynn TG & Smithies O (1995) Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension. Science 267, 679681.
  • 108
    Kishimoto I, Dubois SK & Garbers DL (1996) The heart communicates with the kidney exclusively through the guanylyl cyclase-A receptor: acute handling of sodium and water in response to volume expansion. Proc Natl Acad Sci USA 93, 62156219.
  • 109
    Shi SJ, Nguyen HT, Sharma GD, Navar LG & Pandey KN (2001) Genetic disruption of atrial natriuretic peptide receptor-A alters renin and angiotensin II levels. Am J Physiol 281, F665F673.
  • 110
    Melo LG, Veress AT, Ackermann U, Steinhelper ME, Pang SC, Tse Y & Sonnenberg H (1999) Chronic regulation of arterial blood pressure in ANP transgenic and knockout mice: role of cardiovascular sympathetic tone. Cardiovasc Res 43, 437444.
  • 111
    Steinhelper ME, Cochrane KL & Field LJ (1990) Hypotension in transgenic mice expressing atrial natriuretic factor fusion genes. Hypertension 16, 301307.
  • 112
    Lin KF, Chao J & Chao L (1995) Human atrial natriuretic peptide gene delivery reduces blood pressure in hypertensive rats. Hypertension 26, 847853.
  • 113
    Schillinger KJ, Tsai SY, Taffet GE, Reddy AK, Marian AJ, Entman ML, Oka K, Chan L & O’Malley BW (2005) Regulatable atrial natriuretic peptide gene therapy for hypertension. Proc Natl Acad Sci USA 102, 1378913794.
  • 114
    Deschepper CF, Masciotra S, Zahabi A, Boutin-Ganache I, Picard S & Reudelhuber TL (2001) Function alterations of the Nppa promoter are linked to cardiac ventricular hypertrophy in WKY/WKHA rat crosses. Circ Res 88, 223228.
  • 115
    Zhao D, Vellaichamy E, Somanna NK & Pandey KN (2007) Guanylyl cyclase/natriuretic peptide receptor-A gene disruption causes increased adrenal angiotensin II and aldosterone levels. Am J Physiol Renal Physiol 293, F121F127.
  • 116
    Galet C, Min L, Narayanan R, Kishi M, Weigel NL & Ascoli M (2003) Identification of a transferable two-amino-acid motif (GT) present in the C-terminal tail of the human lutropin receptor that redirects internalized G protein-coupled receptors from a degradation to a recycling pathway. Mol Endocrinol 17, 411422.
  • 117
    Schreier B, Borner S, Volker K, Gambaryan S, Schafer SC, Kuhlencordt P, Gassner B & Kuhn M (2008) The heart communicates with the endothelium through the guanylyl cyclase-A receptor: acute handling of intravascular volume in response to volume expansion. Endocrinology 149, 41934199.
  • 118
    Oliver PM, John SW, Purdy KE, Kim R, Maeda N, Goy MF & Smithies O (1998) Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner. Proc Natl Acad Sci USA 95, 25472551.
  • 119
    Atarashi K, Mulrow PJ, Franco-Saenz R, Snajdar R & Rapp J (1984) Inhibition of aldosterone production by an atrial extract. Science 224, 992994.
  • 120
    Knowles JW, Esposito G, Mao L, Hagaman JR, Fox JE, Smithies O, Rockman HA & Maeda N (2001) Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice. J Clin Invest 107, 975984.
  • 121
    Klinger JR, Warburton RR, Pietras L, Oliver P, Fox J, Smithies O & Hill NS (2002) Targeted disruption of the gene for natriuretic peptide receptor-A worsens hypoxia-induced cardiac hypertrophy. Am J Physiol Heart Circ Physiol 282, H58H65.
  • 122
    Lopez MJ, Wong SK, Kishimoto I, Dubois S, Mach V, Friesen J, Garbers DL & Beuve A (1995) Salt-resistant hypertension in mice lacking the guanylyl cyclase-A receptor for atrial natriuretic peptide. Nature 378, 6568.
  • 123
    Chen HH & Burnett JC Jr (1999) The natriuretic peptides in heart failure: diagnostic and therapeutic potentials. Proc Assoc Am Physicians 111, 406416.
  • 124
    Felker GM, Petersen JW & Mark DB (2006) Natriuretic peptides in the diagnosis and management of heart failure. CMAJ 175, 611617.
  • 125
    Reinhart K, Meisner M & Brunkhorst FM (2006) Markers for sepsis diagnosis: what is useful? Crit Care Clin 22, 503519.
  • 126
    Ellmers LJ, Scott NJ, Piuhola J, Maeda N, Smithies O, Frampton CM, Richards AM & Cameron VA (2007) Npr1-regulated gene pathways contributing to cardiac hypertrophy and fibrosis. J Mol Endocrinol 38, 245257.
  • 127
    Vellaichamy E, Zhao D, Somanna N & Pandey KN (2007) Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates ACE and AT1 receptor gene expression and signaling: role in cardiac hypertrophy. Physiol Genomics 31, 193202.
  • 128
    Xue H, Wang S, Wang H, Sun K, Song X, Zhang W, Fu C, Han Y & Hui R (2008) Atrial natriuretic peptide gene promoter polymorphism is associated with left ventricular hypertrophy in hypertension. Clin Sci (Lond) 114, 131137.
  • 129
    Tsutamoto T, Kanamori T, Morigami N, Sugimoto Y, Yamaoka O & Kinoshita M (1993) Possibility of downregulation of atrial natriuretic peptide receptor coupled to guanylate cyclase in peripheral vascular beds of patients with chronic severe heart failure. Circulation 87, 7075.
  • 130
    See R & de Lemos JA (2006) Current status of risk stratification methods in acute coronary syndromes. Curr Cardiol Rep 8, 282288.
  • 131
    Jaffe AS, Babuin L & Apple FS (2006) Biomarkers in acute cardiac disease: the present and the future. J Am Coll Cardiol 48, 111.
  • 132
    Doust JA, Pietrzak E, Dobson A & Glasziou P (2005) How well does B-type natriuretic peptide predict death and cardiac events in patients with heart failure: systematic review. BWJ, 330, 330625.
  • 133
    Khan IA, Fink J, Nass C, Chen H, Christenson R & deFilippi CR (2006) N-terminal pro-B-type natriuretic peptide and B-type natriuretic peptide for identifying coronary artery disease and left ventricular hypertrophy in ambulatory chronic kidney disease patients. Am J Cardiol 97, 15301534.
  • 134
    Zahabi A, Picard S, Fortin N, Reudelhuber TL & Deschepper CF (2003) Expression of constitutively active guanylate cyclase in cardiomyocytes inhibits the hypertrophic effects of isoproterenol and aortic constriction on mouse hearts. J Biol Chem 278, 4769447699.
  • 135
    Nakanishi M, Saito Y, Kishimoto I, Harada M, Kuwahara K, Takahashi N, Kawakami R, Nakagawa Y, Tanimoto K, Yasuno S et al. (2005) Role of natriuretic peptide receptor guanylyl cyclase-A in myocardial infarction evaluated using genetically engineered mice. Hypertension 46, 441447.
  • 136
    Ellmers LJ, Knowles JW, Kim HS, Smithies O, Maeda N & Cameron VA (2002) Ventricular expression of natriuretic peptides in Npr1(–/–) mice with cardiac hypertrophy and fibrosis. Am J Physiol Heart Circ Physiol 283, H707H714.
  • 137
    Scott NJ, Ellmers LJ, Lainchbury JG, Maeda N, Smithies O, Richards AM & Cameron VA (2009) Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development. Biochim Biophys Acta 1792, 11751184.
  • 138
    Li Y, Kishimoto I, Saito Y, Harada M, Kuwahara K, Izumi T, Takahashi N, Kawakami R, Tanimoto K, Nakagawa Y et al. (2002) Guanylyl cyclase-A inhibits angiotensin II type 1A receptor-mediated cardiac remodeling, an endogenous protective mechanism in the heart. Circulation 106, 17221728.
  • 139
    Kilic A, Bubikat A, Gassner B, Baba HA & Kuhn M (2007) Local actions of atrial natriuretic peptide counteract angiotensin II stimulated cardiac remodeling. Endocrinology 148, 41624169.
  • 140
    Sabrane K, Kruse MN, Fabritz L, Zetsche B, Mitko D, Skryabin BV, Zwiener M, Baba HA, Yanagisawa M & Kuhn M (2005) Vascular endothelium is critically involved in the hypotensive and hypovolemic actions of atrial natriuretic peptide. J Clin Invest 115, 16661674.
  • 141
    Alexander MR, Knowles JW, Nishikimi T & Maeda N (2003) Increased atherosclerosis and smooth muscle cell hypertrophy in natriuretic peptide receptor A−/−apolipoprotein E−/− mice. Arterioscler Thromb Vasc Biol 23, 10771082.
  • 142
    Kishimoto I, Tokudome T, Nakao K & Kangawa K (2011) The cardiovascular significance of the natriuretic peptide system. FEBS J, in press.
  • 143
    Tamura N, Doolittle LK, Hammer RE, Shelton JM, Richardson JA & Garbers DL (2004) Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs. Proc Natl Acad Sci USA 101, 1730017305.
  • 144
    Bartels CF, Bukulmez H, Padayatti P, Rhee DK, van Ravenswaaij-Arts C, Pauli RM, Mundlos S, Chitayat D, Shih LY, Al-Gazali LI et al. (2004) Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux. Am J Hum Genet 75, 2734.
  • 145
    Cermak R, Kleta R, Forssmann WG & Schlatter E (1996) Natriuretic peptides increase a K+ conductance in rat mesangial cells. Pflugers Arch 431, 571577.
  • 146
    Light DB, Schwiebert EM, Karlson KH & Stanton BA (1989) Atrial natriuretic peptide inhibits a cation channel in renal inner medullary collecting duct cells. Science 243, 383385.
  • 147
    Nonoguchi H, Knepper MA & Manganiello VC (1987) Effects of atrial natriuretic factor on cyclic guanosine monophosphate and cyclic adenosine monophosphate accumulation in microdissected nephron segments from rats. J Clin Invest 79, 500507.
  • 148
    Appel RG (1992) Growth-regulatory properties of atrial natriuretic factor. Am J Physiol 262, F911F918.
  • 149
    Burnett JC Jr, Granger JP & Opgenorth TJ (1984) Effects of synthetic atrial natriuretic factor on renal function and renin release. Am J Physiol 247, F863F866.
  • 150
    Kurtz A, Della Bruna R, Pfeilschifter J, Taugner R & Bauer C (1986) Atrial natriuretic peptide inhibits renin release from juxtaglomerular cells by a cGMP-mediated process. Proc Natl Acad Sci USA 83, 47694773.
  • 151
    von Geldern TW, Budzik GP, Dillon TP, Holleman WH, Holst MA, Kiso Y, Novosad EI, Opgenorth TJ, Rockway TW, Thomas AM et al. (1990) Atrial natriuretic peptide antagonists: biological evaluation and structural correlations. Mol Pharmacol 38, 771778.
  • 152
    Kumar R, Cartledge WA, Lincoln TM & Pandey KN (1997) Expression of guanylyl cyclase-A/atrial natriuretic peptide receptor blocks the activation of protein kinase C in vascular smooth muscle cells. Role of cGMP and cGMP-dependent protein kinase. Hypertension 29, 414421.
  • 153
    Zhao D, Pandey KN & Navar LG (2010) ANP-mediated inhibition of distal nephron fractional sodium reabsorption in wild-type and mice overexpressing natriuretic peptide receptor. Am J Physiol Renal Physiol 298, F103F108.
  • 154
    Cao L, Wu J & Gardner DG (1995) Atrial natriuretic peptide suppresses the transcription of its guanylyl cyclase-linked receptor. J Biol Chem 270, 2489124897.
  • 155
    Sharma GD, Nguyen HT, Antonov AS, Gerrity RG, von Geldern T & Pandey KN (2002) Expression of atrial natriuretic peptide receptor-A antagonizes the mitogen-activated protein kinases (Erk2 and P38MAPK) in cultured human vascular smooth muscle cells. Mol Cell Biochem 233, 165173.
  • 156
    Lincoln TM, Dey N & Sellak H (2001) Invited review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression. J Appl Physiol 91, 14211430.
  • 157
    Khurana ML & Pandey KN (1996) Atrial natriuretic peptide inhibits the phosphoinositide hydrolysis in murine Leydig tumor cells. Mol Cell Biochem 158, 97105.
  • 158
    Levin ER & Frank HJ (1991) Natriuretic peptides inhibit rat astroglial proliferation: mediation by C receptor. Am J Physiol 261, R453R457.
  • 159
    Chrisman TD & Garbers DL (1999) Reciprocal antagonism coordinates C-type natriuretic peptide and mitogen-signaling pathways in fibroblasts. J Biol Chem 274, 42934299.
  • 160
    Wu CF, Bishopric NH & Pratt RE (1997) Atrial natriuretic peptide induces apoptosis in neonatal rat cardiac myocytes. J Biol Chem 272, 1486014866.
  • 161
    Hutchinson HG, Trindade PT, Cunanan DB, Wu CF & Pratt RE (1997) Mechanisms of natriuretic-peptide-induced growth inhibition of vascular smooth muscle cells. Cardiovasc Res 35, 158167.
  • 162
    Prins BA, Weber MJ, Hu RM, Pedram A, Daniels M & Levin ER (1996) Atrial natriuretic peptide inhibits mitogen-activated protein kinase through the clearance receptor. Potential role in the inhibition of astrocyte proliferation. J Biol Chem 271, 1415614162.
  • 163
    Rose RA & Giles WR (2008) Natriuretic peptide C receptor signalling in the heart and vasculature. J Physiol 586, 353366.
  • 164
    Newton-Cheh C, Larson MG, Vasan RS, Levy D, Bloch KD, Surti A, Guiducci C, Kathiresan S, Benjamin EJ, Struck J et al. (2009) Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. Nat Genet 41, 348353.
  • 165
    Rubattu S, Bigatti G, Evangelista A, Lanzani C, Stanzione R, Zagato L, Manunta P, Marchitti S, Venturelli V, Bianchi G et al. (2006) Association of atrial natriuretic peptide and type a natriuretic peptide receptor gene polymorphisms with left ventricular mass in human essential hypertension. J Am Coll Cardiol 48, 499505.
  • 166
    Webber MA & Marder SR (2008) Better pharmacotherapy for schizophrenia: what does the future hold? Curr Psychiatry Rep 10, 352358.
  • 167
    Levy D, DeStefano AL, Larson MG, O’Donnell CJ, Lifton RP, Gavras H, Cupples LA & Myers RH (2000) Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the Framingham Heart Study. Hypertension 36, 477483.
  • 168
    Ji W, Foo JN, O’Roak BJ, Zhao H, Larson MG, Simon DB, Newton-Cheh C, State MW, Levy D & Lifton RP (2008) Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nat Genet 40, 592599.
  • 169
    Lifton RP, Gharavi AG & Geller DS (2001) Molecular mechanisms of human hypertension. Cell 104, 545556.
  • 170
    Knowles JW, Erickson LM, Guy VK, Sigel CS, Wilder JC & Maeda N (2003) Common variations in noncoding regions of the human natriuretic peptide receptor A gene have quantitative effects. Hum Genet 112, 6270.