Natriuretic peptide metabolism, clearance and degradation


L. R. Potter, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota-Twin Cities, 6–155 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
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Atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide constitute a family of three structurally related, but genetically distinct, signaling molecules that regulate the cardiovascular, skeletal, nervous, reproductive and other systems by activating transmembrane guanylyl cyclases and elevating intracellular cGMP concentrations. This review broadly discusses the general characteristics of natriuretic peptides and their cognate signaling receptors, and then specifically discusses the tissue-specific metabolism of natriuretic peptides and their degradation by neprilysin, insulin-degrading enzyme, and natriuretic peptide receptor-C.