Membrane protein integration into the endoplasmic reticulum

Authors

  • Luis Martínez-Gil,

    1. Departament de Bioquímica i Biologia Molecular, Universitat de València, Burjassot, Spain
    2. Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
    Search for more papers by this author
    • These authors contributed equally to this work

  • Ana Saurí,

    1. Department of Molecular Microbiology, Institute of Molecular Cell Biology, VU University, Amsterdam, The Netherlands
    Search for more papers by this author
    • These authors contributed equally to this work

  • Marc A. Marti-Renom,

    1. Structural Genomics Laboratory, Centro de Investigación Príncipe Felipe, Valencia, Spain
    Search for more papers by this author
  • Ismael Mingarro

    1. Departament de Bioquímica i Biologia Molecular, Universitat de València, Burjassot, Spain
    Search for more papers by this author

I. Mingarro, Departament de Bioquímica i Biologia Molecular, Universitat de València, E46100 Burjassot, Spain
Fax: +34 963544635
Tel: +34 963543796
E-mail: Ismael.Mingarro@uv.es

Abstract

Most integral membrane proteins are targeted, inserted and assembled in the endoplasmic reticulum membrane. The sequential and potentially overlapping events necessary for membrane protein integration take place at sites termed translocons, which comprise a specific set of membrane proteins acting in concert with ribosomes and, probably, molecular chaperones to ensure the success of the whole process. In this minireview, we summarize our current understanding of helical membrane protein integration at the endoplasmic reticulum, and highlight specific characteristics that affect the biogenesis of multispanning membrane proteins.

Ancillary