Characterizing the complexity of enzymes on the basis of their mechanisms and structures with a bio-computational analysis
Article first published online: 13 JUN 2011
© 2011 The Authors Journal compilation © 2011 FEBS
Special Issue: Protein Structure and Proteomics
Volume 278, Issue 20, pages 3835–3845, October 2011
How to Cite
Holliday, G. L., Fischer, J. D., Mitchell, J. B. O. and Thornton, J. M. (2011), Characterizing the complexity of enzymes on the basis of their mechanisms and structures with a bio-computational analysis. FEBS Journal, 278: 3835–3845. doi: 10.1111/j.1742-4658.2011.08190.x
- Issue published online: 28 SEP 2011
- Article first published online: 13 JUN 2011
- Accepted manuscript online: 23 MAY 2011 10:12AM EST
- (Received 5 April 2011, revised 16 May 2011, accepted 20 May 2011)
Fig. S1. The process of identifying first unique combinations of CATH domains for different proteins and then the second level of clustering, which takes into account the sequence identity in order to minimize the effect of domain ‘piggybacking’.
Table S1. The propensity of a residue to be catalytic in each of the six classes of enzyme.
Table S2. The coverage of single-domain enzymes with respect to the EC classification.
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