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References

  • 1
    Blackburn EH (1992) Telomerases. Annu Rev Biochem 61, 113129.
  • 2
    Makarov VL, Hirose Y & Langmore JP (1997) Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 88, 657666.
  • 3
    Wright WE, Tesmer VM, Huffman KE, Levene SD & Shay JW (1997) Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev 11, 28012809.
  • 4
    Shay JW & Wright WE (1996) Telomerase activity in human cancer. Curr Opin Oncol 8, 6671.
  • 5
    Shay JW & Keith WN (2008) Targeting telomerase for cancer therapeutics. Br J Cancer 98, 677683.
  • 6
    Shay JW & Wright WE (2006) Telomerase therapeutics for cancer: challenges and new directions. Nat Rev Drug Discov 5, 577584.
  • 7
    Kim MM, Rivera MA, Botchkina IL, Shalaby R, Thor AD & Blackburn EH (2001) A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation. Proc Natl Acad Sci USA 98, 79827987.
  • 8
    Li S, Rosenberg JE, Donjacour AA, Botchkina IL, Hom YK, Cunha GR & Blackburn EH (2004) Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA. Cancer Res 64, 48334840.
  • 9
    Marusic L, Anton M, Tidy A, Wang P, Villeponteau B & Bacchetti S (1997) Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability. Mol Cell Biol 17, 63946401.
  • 10
    Goldkorn A & Blackburn EH (2006) Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells. Cancer Res 66, 57635771.
  • 11
    Li S, Crothers J, Haqq CM & Blackburn EH (2005) Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA. J Biol Chem 280, 2370923717.
  • 12
    Stohr BA & Blackburn EH (2008) ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells. Cancer Res 68, 53095317.
  • 13
    Takai H, Smogorzewska A & de Lange T (2003) DNA damage foci at dysfunctional telomeres. Curr Biol 13, 15491556.
  • 14
    Herbig U, Jobling WA, Chen BP, Chen DJ & Sedivy JM (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 14, 501513.
  • 15
    Xu L & Blackburn EH (2004) Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules. J Cell Biol 167, 819830.
  • 16
    Karlseder J, Broccoli D, Dai Y, Hardy S & de Lange T (1999) p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283, 13211325.
  • 17
    Zhang W, Hoffman B & Liebermann DA (2001) Ectopic expression of MyD118/Gadd45/CR6 (Gadd45beta/alpha/gamma) sensitizes neoplastic cells to genotoxic stress-induced apoptosis. Int J Oncol 18, 749757.
  • 18
    Bakkenist CJ & Kastan MB (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499506.
  • 19
    Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, Smorodinsky NI, Prives C, Reiss Y, Shiloh Y et al. (1998) Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281, 16741677.
  • 20
    Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB & Siliciano JD (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281, 16771679.
  • 21
    Tibbetts RS, Brumbaugh KM, Williams JM, Sarkaria JN, Cliby WA, Shieh SY, Taya Y, Prives C & Abraham RT (1999) A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev 13, 152157.
  • 22
    Horikawa I, Fujita K & Harris CC (2011) p53 governs telomere regulation feedback too, via TRF2. Aging (Albany NY) 3, 2632.
  • 23
    Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, Caddle SD, Ziaugra L, Beijersbergen RL, Davidoff MJ, Liu Q et al. (1997) hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90, 785795.
  • 24
    Redon S, Reichenbach P & Lingner J (2010) The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase. Nucleic Acids Res 38, 57975806.
  • 25
    Riballo E, Kuhne M, Rief N, Doherty A, Smith GC, Recio MJ, Reis C, Dahm K, Fricke A, Krempler A et al. (2004) A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell 16, 715724.
  • 26
    FitzGerald JE, Grenon M & Lowndes NF (2009) 53BP1: function and mechanisms of focal recruitment. Biochem Soc Trans 37, 897904.
  • 27
    Vukovic B, Beheshti B, Park P, Lim G, Bayani J, Zielenska M & Squire JA (2007) Correlating breakage-fusion-bridge events with the overall chromosomal instability and in vitro karyotype evolution in prostate cancer. Cytogenet Genome Res 116, 111.
  • 28
    Zheng YZ, Roseman RR & Carlson WR (1999) Time course study of the chromosome-type breakage-fusion-bridge cycle in maize. Genetics 153, 14351444.
  • 29
    Smogorzewska A & de Lange T (2002) Different telomere damage signaling pathways in human and mouse cells. EMBO J 21, 43384348.
  • 30
    Durocher D & Jackson SP (2001) DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr Opin Cell Biol 13, 225231.
  • 31
    Toyoshima T, Kamijo R, Takizawa K, Sumitani K, Ito D & Nagumo M (2002) Inhibitor of cyclooxygenase-2 induces cell-cycle arrest in the epithelial cancer cell line via up-regulation of cyclin dependent kinase inhibitor p21. Br J Cancer 86, 11501156.
  • 32
    Han J, Tsukada Y, Hara E, Kitamura N & Tanaka T (2005) Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells. J Biol Chem 280, 3154831556.
  • 33
    Aprelikova O, Pace AJ, Fang B, Koller BH & Liu ET (2001) BRCA1 is a selective co-activator of 14-3-3 sigma gene transcription in mouse embryonic stem cells. J Biol Chem 276, 2564725650.
  • 34
    Cretu A, Sha X, Tront J, Hoffman B & Liebermann DA (2009) Stress sensor Gadd45 genes as therapeutic targets in cancer. Cancer Ther 7, 268276.
  • 35
    Tront JS, Hoffman B & Liebermann DA (2006) Gadd45a suppresses Ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence. Cancer Res 66, 84488454.
  • 36
    Zerbini LF, Wang Y, Czibere A, Correa RG, Cho JY, Ijiri K, Wei W, Joseph M, Gu X, Grall F et al. (2004) NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival. Proc Natl Acad Sci USA 101, 1361813623.
  • 37
    Zerbini LF & Libermann TA (2005) Life and death in cancer. GADD45 alpha and gamma are critical regulators of NF-kappaB mediated escape from programmed cell death. Cell Cycle 4, 1820.
  • 38
    Brower V (2010) Telomerase-based therapies emerging slowly. J Natl Cancer Inst 102, 520521.
  • 39
    Cong Y & Shay JW (2008) Actions of human telomerase beyond telomeres. Cell Res 18, 725732.
  • 40
    Tokcaer-Keskin Z, Dikmen ZG, Ayaloglu-Butun F, Gultekin S, Gryaznov SM & Akcali KC (2010) The effect of telomerase template antagonist GRN163L on bone-marrow-derived rat mesenchymal stem cells is reversible and associated with altered expression of cyclin d1, cdk4 and cdk6. Stem Cell Rev 6, 224233.