Figs S1–S6. Stern–Volmer plots for data presented in Table 1.

Fig. S7.15N edited TOCSY-HSQC and NOESY-HSQC strip plots for selected residues in thiamine binding pocket.

Fig. S8. NMR spectra of thiamine (free) and thiamine bound to shPrP.

Table S1. List of human metabolites used in the screening process.

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