• 1
    Sakai T, Sameshima T, Matsufuji M, Kawamura N, Dobashi K & Mizui Y (2004) Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. I. Taxonomy, fermentation, isolation and screening. J Antibiot (Tokyo) 57, 173179.
  • 2
    Sakai T, Asai N, Okuda A, Kawamura N & Mizui Y (2004) Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. II. Physico-chemical properties and structure elucidation. J Antibiot (Tokyo) 57, 180187.
  • 3
    Mizui Y, Sakai T, Iwata M, Uenaka T, Okamoto K, Shimizu H, Yamori T, Yoshimatsu K & Asada M (2004) Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities. J Antibiot (Tokyo) 57, 188196.
  • 4
    Yamori T (2003) Panel of human cancer cell lines provides valuable database for drug discovery and bioinformatics. Cancer Chemother Pharmacol 52(Suppl 1), S74S79.
  • 5
    Kotake Y, Sagane K, Owa T, Mimori-Kiyosue Y, Shimizu H, Uesugi M, Ishihama Y, Iwata M & Mizui Y (2007) Splicing factor SF3b as a target of the antitumor natural product pladienolide. Nat Chem Biol 3, 570575.
  • 6
    Folco EG, Coil KE & Reed R (2011) The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region. Genes Dev 25, 440444.
  • 7
    Das BK, Xia L, Palandjian L, Gozani O, Chyung Y & Reed R (1999) Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155. Mol Cell Biol 19, 67966802.
  • 8
    Kramer A, Gruter P, Groning K & Kastner B (1999) Combined biochemical and electron microscopic analyses reveal the architecture of the mammalian U2 snRNP. J Cell Biol 145, 13551368.
  • 9
    Will CL, Schneider C, MacMillan AM, Katopodis NF, Neubauer G, Wilm M, Luhrmann R & Query CC (2001) A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site. EMBO J 20, 45364546.
  • 10
    Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M & Luhrmann R (2002) Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. EMBO J 21, 49784988.
  • 11
    Gozani O, Potashkin J & Reed R (1998) A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site. Mol Cell Biol 18, 47524760.
  • 12
    Cass DM & Berglund JA (2006) The SF3b155 N-terminal domain is a scaffold important for splicing. Biochemistry 45, 1009210101.
  • 13
    Wang C, Chua K, Seghezzi W, Lees E, Gozani O & Reed R (1998) Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis. Genes Dev 12, 14091414.
  • 14
    Groves MR, Hanlon N, Turowski P, Hemmings BA & Barford D (1999) The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. Cell 96, 99110.
  • 15
    Cingolani G, Petosa C, Weis K & Muller CW (1999) Structure of importin-beta bound to the IBB domain of importin-alpha. Nature 399, 221229.
  • 16
    Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU & Burley SK (2001) A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery. Mol Cell 7, 193203.
  • 17
    Golas MM, Sander B, Will CL, Luhrmann R & Stark H (2003) Molecular architecture of the multiprotein splicing factor SF3b. Science 300, 980984.
  • 18
    Wheeler JM, Beck NE, Kim HC, Tomlinson IP, Mortensen NJ & Bodmer WF (1999) Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1. Proc Natl Acad Sci USA 96, 1029610301.
  • 19
    Papadopoulos N, Nicolaides NC, Liu B, Parsons R, Lengauer C, Palombo F, D’Arrigo A, Markowitz S, Willson JK, Kinzler KW et al. (1995) Mutations of GTBP in genetically unstable cells. Science 268, 19151917.
  • 20
    Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M et al. (2011) Frequent pathway mutations of splicing machinery in myelodysplasia. Nature 478, 6469.
  • 21
    Visconte V, Makishima H, Jankowska A, Szpurka H, Traina F, Jerez A, O’Keefe C, Rogers HJ, Sekeres MA, Maciejewski JP et al. (2011) SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts. Leukemia, doi:10.1038/leu.2011.232.
  • 22
    Isono K, Abe K, Tomaru Y, Okazaki Y, Hayashizaki Y & Koseki H (2001) Molecular cloning, genetic mapping, and expression of the mouse Sf3b1 (SAP155) gene for the U2 snRNP component of spliceosome. Mamm Genome 12, 192198.
  • 23
    Kaida D, Motoyoshi H, Tashiro E, Nojima T, Hagiwara M, Ishigami K, Watanabe H, Kitahara T, Yoshida T, Nakajima H et al. (2007) Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nat Chem Biol 3, 576583.