Identification and analysis of functionally important amino acids in human purinergic 12 receptor using a Saccharomyces cerevisiae expression system
Article first published online: 23 NOV 2011
© 2011 The Authors Journal compilation © 2011 FEBS
Volume 279, Issue 1, pages 180–191, January 2012
How to Cite
Ignatovica, V., Megnis, K., Lapins, M., Schiöth, H. B. and Klovins, J. (2012), Identification and analysis of functionally important amino acids in human purinergic 12 receptor using a Saccharomyces cerevisiae expression system. FEBS Journal, 279: 180–191. doi: 10.1111/j.1742-4658.2011.08410.x
- Issue published online: 13 DEC 2011
- Article first published online: 23 NOV 2011
- Accepted manuscript online: 1 NOV 2011 07:59AM EST
- (Received 30 May 2011, revised 30 September 2011, accepted 28 October 2011)
Fig. S1. Activation curves of wt P2Y12 after stimulation with ADP and 2MeSADP.
Fig. S2. Activation curves of recombinant P2Y12s with ADP and ADP + 1 μm AR-C66096. (A) wt P2Y12R, (B) E181R, (C) E181D, (D) E181A, (E) E181I, (F) E181Y, (G) R256I, (H) R265K, (I) R265D, (J) R265A, (K) R265F, (L) R265S.
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