Identification of interleukin-1 receptor-associated kinase 1 as a critical component that induces post-transcriptional activation of IκB-ζ
Version of Record online: 30 NOV 2011
© 2011 The Authors Journal compilation © 2011 FEBS
The FEBS Journal
Volume 279, Issue 2, pages 211–222, January 2012
How to Cite
Ohba, T., Ariga, Y., Maruyama, T., Truong, N. K., Inoue, J.-i. and Muta, T. (2012), Identification of interleukin-1 receptor-associated kinase 1 as a critical component that induces post-transcriptional activation of IκB-ζ. The FEBS Journal, 279: 211–222. doi: 10.1111/j.1742-4658.2011.08416.x
- Issue online: 3 JAN 2012
- Version of Record online: 30 NOV 2011
- Accepted manuscript online: 7 NOV 2011 07:52AM EST
- (Received 17 September 2011, revised 18 October 2011, accepted 2 November 2011)
Fig. S1. Overexpression of MyD88, IRAK1, or TRAF6, but not of IRAK4, elicits activation of NF-κB and post-transcriptional regulation via the 165-nucleotide element in HEK293 cells.
Fig. S2. Overexpression of IRAK1, but not of TRAF6, elicits activation of post-transcriptional regulation via the 165-nucleotide element in RAW264.7 cells.
Fig. S3. OHT-mediated activation of the ER(T2) fusion proteins of IRAK1 mutants with a mutation(s) at the ubiquitination site Lys134 and/or Lys180 elicits NF-κB activation and 165-nucleotide element-mediated post-transcriptional activation.
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