• 1
    Moorhead GB, Trinkle-Mulcahy L & Ulke-Lemee A (2007) Emerging roles of nuclear protein phosphatases. Nat Rev Mol Cell Biol8, 234244.
  • 2
    Brautigan DL (2012) Historical introduction to protein Ser/Thr phosphatases. FEBS J279, in press.
  • 3
    Virshup DM & Shenolikar S (2009) From promiscuity to precision: protein phosphatases get a makeover. Mol Cell33, 537545.
  • 4
    Bollen M, Peti W, Ragusa MJ & Beullens M (2010) The extended PP1 toolkit: designed to create specificity. Trends Biochem Sci35, 450458.
  • 5
    Peti W, Nairn A & Page R (2012) Structural basis for protein phosphatase 1 regulation and specificity. FEBS J279, doi:10.1111/j.1742-4658.2012.08509.x.
  • 6
    Ceulemans H, Stalmans W & Bollen M (2002) Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. BioEssays24, 371381.
  • 7
    Gibbons JA, Kozubowski L, Tatchell K & Shenolikar S (2007) Expression of human protein phosphatase-1 in Saccharomyces cerevisiae highlights the role of phosphatase isoforms in regulating eukaryotic functions. J Biol Chem282, 2183821847.
  • 8
    Patil A, Kinoshita K & Nakamura H (2010) Domain distribution and intrinsic disorder in hubs in the human protein–protein interaction network. Protein Sci19, 14611468.
  • 9
    Hendrickx A, Beullens M, Ceulemans H, Den AT, Van Eynde A, Nicolaescu E, Lesage B & Bollen M (2009) Docking motif-guided mapping of the interactome of protein phosphatase-1. Chem Biol16, 365371.
  • 10
    Terrak M, Kerff F, Langsetmo K, Tao T & Dominguez R (2004) Structural basis of protein phosphatase 1 regulation. Nature429, 780784.
  • 11
    Hurley TD, Yang J, Zhang L, Goodwin KD, Zou Q, Cortese M, Dunker AK & DePaoli-Roach AA (2007) Structural basis for regulation of protein phosphatase 1 by inhibitor-2. J Biol Chem282, 2887428883.
  • 12
    Eto M, Kitazawa T, Matsuzawa F, Aikawa S, Kirkbride JA, Isozumi N, Nishimura Y, Brautigan DL & Ohki SY (2007) Phosphorylation-induced conformational switching of CPI-17 produces a potent myosin phosphatase inhibitor. Structure15, 15911602.
  • 13
    Ragusa MJ, Dancheck B, Critton DA, Nairn AC, Page R & Peti W (2010) Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites. Nat Struct Mol Biol17, 459464.
  • 14
    Dancheck B, Ragusa MJ, Allaire M, Nairn AC, Page R & Peti W (2011) Molecular investigations of the structure and function of the protein phosphatase 1-spinophilin-inhibitor 2 heterotrimeric complex. Biochemistry50, 12381246.
  • 15
    Manna B, Bhattacharya T, Kahali B & Ghosh TC (2009) Evolutionary constraints on hub and non-hub proteins in human protein interaction network: insight from protein connectivity and intrinsic disorder. Gene434, 5055.
  • 16
    Egloff MP, Johnson DF, Moorhead G, Cohen PT, Cohen P & Barford D (1997) Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1. EMBO J16, 18761887.
  • 17
    Wakula P, Beullens M, Ceulemans H, Stalmans W & Bollen M (2003) Degeneracy and function of the ubiquitous RVXF motif that mediates binding to protein phosphatase-1. J Biol Chem278, 1881718823.
  • 18
    Barford D, Das AK & Egloff MP (1998) The structure and mechanism of protein phosphatases: insights into catalysis and regulation. Annu Rev Biophys Biomol Struct27, 133164.
  • 19
    Goldberg J, Huang HB, Kwon YG, Greengard P, Nairn AC & Kuriyan J (1995) Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1. Nature376, 745753.
  • 20
    Ceulemans H, Vulsteke V, De Maeyer M, Tatchell K, Stalmans W & Bollen M (2002) Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. J Biol Chem277, 4733147337.
  • 21
    Llanos S, Royer C, Lu M, Bergamaschi D, Lee WH & Lu X (2011) Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif. J Biol Chem286, 4303943044.
  • 22
    Katayama H, Zhou H, Li Q, Tatsuka M & Sen S (2001) Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. J Biol Chem276, 4621946224.
  • 23
    Trinkle-Mulcahy L, Andersen J, Lam YW, Moorhead G, Mann M & Lamond AI (2006) Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability. J Cell Biol172, 679692.
  • 24
    Hrabchak C, Henderson H & Varmuza S (2007) A testis specific isoform of endophilin B1, endophilin B1t, interacts specifically with protein phosphatase-1c gamma2 in mouse testis and is abnormally expressed in PP1c gamma null mice. Biochemistry46, 46354644.
  • 25
    Fardilha M, Esteves SL, Korrodi-Gregorio L, Vintem AP, Domingues SC, Rebelo S, Morrice N, Cohen PT, da Cruz e Silva OA & da Cruz e Silva EF (2011) Identification of the human testis protein phosphatase 1 interactome. Biochem Pharmacol82, 14031415.
  • 26
    Terry-Lorenzo RT, Carmody LC, Voltz JW, Connor JH, Li S, Smith FD, Milgram SL, Colbran RJ & Shenolikar S (2002) The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits. J Biol Chem277, 2771627724.
  • 27
    Carmody LC, Bauman PA, Bass MA, Mavila N, DePaoli-Roach AA & Colbran RJ (2004) A protein phosphatase-1gamma1 isoform selectivity determinant in dendritic spine-associated neurabin. J Biol Chem279, 2171421723.
  • 28
    Carmody LC, Baucum AJ, Bass MA & Colbran RJ (2008) Selective targeting of the gamma1 isoform of protein phosphatase 1 to F-actin in intact cells requires multiple domains in spinophilin and neurabin. FASEB J22, 16601671.
  • 29
    Lesage B, Beullens M, Ceulemans H, Himpens B & Bollen M (2005) Determinants of the nucleolar targeting of protein phosphatase-1. FEBS Lett579, 56265630.
  • 30
    Yang J, Roe SM, Prickett TD, Brautigan DL & Barford D (2007) The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation. Biochemistry46, 88078815.
  • 31
    Roy J & Cyert MS (2009) Cracking the phosphatase code: docking interactions determine substrate specificity. Sci Signal2, re9.
  • 32
    Meiselbach H, Sticht H & Enz R (2006) Structural analysis of the protein phosphatase 1 docking motif: molecular description of binding specificities identifies interacting proteins. Chem Biol13, 4959.
  • 33
    Gibbons JA, Weiser DC & Shenolikar S (2005) Importance of a surface hydrophobic pocket on protein phosphatase-1 catalytic subunit in recognizing cellular regulators. J Biol Chem280, 1590315911.
  • 34
    Lesage B, Beullens M, Pedelini L, Garcia-Gimeno MA, Waelkens E, Sanz P & Bollen M (2007) A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3. Biochemistry46, 89098919.
  • 35
    Pedelini L, Marquina M, Arino J, Casamayor A, Sanz L, Bollen M, Sanz P & Garcia-Gimeno MA (2007) YPI1 and SDS22 proteins regulate the nuclear localization and function of yeast type 1 phosphatase Glc7. J Biol Chem282, 32823292.
  • 36
    Connor JH, Weiser DC, Li S, Hallenbeck JM & Shenolikar S (2001) Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. Mol Cell Biol21, 68416850.
  • 37
    Trinkle-Mulcahy L, Sleeman JE & Lamond AI (2001) Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells. J Cell Sci114, 42194228.
  • 38
    Svenningsson P, Nishi A, Fisone G, Girault JA, Nairn AC & Greengard P (2004) DARPP-32: an integrator of neurotransmission. Annu Rev Pharmacol Toxicol44, 269296.
  • 39
    Bollen M & Stalmans W (1992) The structure, role, and regulation of type 1 protein phosphatases. Crit Rev Biochem Mol Biol27, 227281.
  • 40
    Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD & Shi Y (2008) Structural mechanism of demethylation and inactivation of protein phosphatase 2A . Cell133, 154163.
  • 41
    Brush MH, Weiser DC & Shenolikar S (2003) Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. Mol Cell Biol23, 12921303.
  • 42
    Bollen M (2001) Combinatorial control of protein phosphatase-1. Trends Biochem Sci26, 426431.
  • 43
    Cohen PT (2002) Protein phosphatase 1 – targeted in many directions. J Cell Sci115, 241256.
  • 44
    Qian J, Lesage B, Beullens M, Van Eynde A & Bollen M (2011) PP1/Repo-man dephosphorylates mitotic histone H3 at T3 and regulates chromosomal aurora B targeting. Curr Biol21, 766773.
  • 45
    Marsh JA, Dancheck B, Ragusa MJ, Allaire M, Forman-Kay JD & Peti W (2010) Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators. Structure18, 10941103.
  • 46
    Peti W, Nairn AC & Page R (2012) Folding of intrinsically disordered protein phosphatase 1 regulatory proteins. Curr Phys Chem, in press.
  • 47
    Takemoto A, Maeshima K, Ikehara T, Yamaguchi K, Murayama A, Imamura S, Imamoto N, Yokoyama S, Hirano T, Watanabe Y et al. (2009) The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A. Nat Struct Mol Biol16, 13021308.
  • 48
    Bollen M, Gerlich DW & Lesage B (2009) Mitotic phosphatases: from entry guards to exit guides. Trends Cell Biol19, 531541.
  • 49
    Kitagawa Y, Sasaki K, Shima H, Shibuya M, Sugimura T & Nagao M (1990) Protein phosphatases possibly involved in rat spermatogenesis. Biochem Biophys Res Commun171, 230235.
  • 50
    Sasaki K, Shima H, Kitagawa Y, Irino S, Sugimura T & Nagao M (1990) Identification of members of the protein phosphatase 1 gene family in the rat and enhanced expression of protein phosphatase 1 alpha gene in rat hepatocellular carcinomas. Jpn J Cancer Res81, 12721280.
  • 51
    Ceulemans H & Bollen M (2004) Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Physiol Rev84, 139.
  • 52
    Huang da W, Sherman BT & Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc4, 4457.
  • 53
    Huang da W, Sherman BT & Lempicki RA (2009) Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res37, 113.
  • 54
    Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G et al. (2004) A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci USA101, 60626067.