SEARCH

SEARCH BY CITATION

References

  • 1
    Hinnebusch AG (2005) Translational regulation of GCN4 and the general amino acid control of yeast. Annu Rev Microbiol 59, 407450.
  • 2
    Sattlegger E & Hinnebusch AG (2000) Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells. EMBO J 19, 66226633.
  • 3
    Marton MJ, Crouch D & Hinnebusch AG (1993) GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2. Mol Cell Biol 13, 35413556.
  • 4
    Triana-Alonso FJ, Chakraburtty K & Nierhaus KH (1995) The elongation-factor-3 unique in higher fungi and essential for protein-biosynthesis is an E-site factor. J Biol Chem 270, 2047320478.
  • 5
    Marton MJ, Vazquez de Aldana CR, Qiu H, Chakraburtty K & Hinnebusch AG (1997) Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2. Mol Cell Biol 17, 44744489.
  • 6
    Ramirez M, Wek RC & Hinnebusch AG (1991) Ribosome association of GCN2 protein-kinase, a translation, a translational activator of the GCN4 gene of Saccharomyces cerevisiae. Mol Cell Biol 11, 30273036.
  • 7
    Sattlegger E & Hinnebusch AG (2005) Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation. J Biol Chem 280, 1651416521.
  • 8
    Cashel M & Rudd KE (1987) The stringent response. In Eschericha coli and Salmonella typhimurium: Cellular and Molecular Biology (Neidhardt FC, Ingraham JL, Magasanik B, Low KB, Schaechter M & Umbarger HE eds), pp. 14101438. American Society for Microbiology, Washington, DC.
  • 9
    Goldman E & Jakubowski H (1990) Uncharged tRNA, protein synthesis, and the bacterial stringent response. Mol Microbiol 4, 20352040.
  • 10
    Pereira CM, Sattlegger E, Jiang HY, Longo BM, Jaqueta CB, Hinnebusch AG, Wek RC, Mello LE & Castilho BA (2005) IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. J Biol Chem 280, 2831628323.
  • 11
    Sattlegger E, Swanson MJ, Ashcraft EA, Jennings JL, Fekete RA, Link AJ & Hinnebusch AG (2004) YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed. J Biol Chem 279, 2995229962.
  • 12
    Kubota H, Sakaki Y & Ito T (2000) GI domain-mediated association of the eukaryotic initiation factor 2α kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast. J Biol Chem 275, 2024320246.
  • 13
    Sattlegger E, Barbosa JARG, Moraes MCS, Martins RM, Hinnebusch AG & Castilho BA (2011) Gcn1 and actin binding to Yih1: implications for activation of the eIF2 kinase Gcn2. J Biol Chem 286, 1034110355.
  • 14
    Hinnebusch AG (2000) Mechanism and regulation of initiator methionyl-tRNA binding to ribosomes. In Translational Control of Gene Expression (Sonenberg N, Hershey JWB & Mathews MB eds), pp. 185243. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
  • 15
    Gietzen DW, Ross CM, Hao SZ & Sharp JW (2004) Phosphorylation of elF2 alpha is involved in the signaling of indispensable amino acid deficiency in the anterior piriform cortex of the brain in rats. J Nutr 134, 717723.
  • 16
    Maurin AC, Jousse C, Averous J, Parry L, Bruhat A, Cherasse Y, Zeng HQ, Zhang YH, Harding HP, Ron D et al. (2005) The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores. Cell Metab 1, 273277.
  • 17
    Costa-Mattioli M, Gobert D, Harding H, Herdy B, Azzi M, Bruno M, Bidinosti M, Ben Mamou C, Marcinkiewicz E, Yoshida M et al. (2005) Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature 436, 11661173.
  • 18
    Fallarino F, Grohmann U, You S, McGrath BC, Cavener DR, Vacca C, Orabona C, Bianchi R, Belladonna ML, Volpi C et al. (2006) The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J Immunol 176, 67526761.
  • 19
    Sutherland BW, Toews J & Kast J (2008) Utility of formaldehyde cross-linking and mass spectrometry in the study of protein–protein interactions. J Mass Spectrom 43, 699715.
  • 20
    Wout PK, Sattlegger E, Sullivan SM & Maddock JR (2009) Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2 interact on polyribosomes with Gcn1. Eukaryot Cell 8, 10611071.
  • 21
    Ghaemmaghami S, Huh W, Bower K, Howson RW, Belle A, Dephoure N, O’Shea EK & Weissman JS (2003) Global analysis of protein expression in yeast. Nature 425, 737741.
  • 22
    Hilton JL, Kearney PC & Ames BN (1965) Mode of action of herbicide 3-amino-1,2,4-triazole (amitrole) – Inhibition of an enzyme of histidine biosynthesis. Arch Biochem Biophys 112, 544547.
  • 23
    Munn A & Sattlegger E (2009) Yeast studies reveal new roles for an ancient skeleton. Aust Biochem 40, 913.
  • 24
    Berlanga JJ, Ventoso I, Harding HP, Deng J, Ron D, Sonenberg N, Carrasco L & de Haro C (2006) Antiviral effect of the mammalian translation initiation factor 2[alpha] kinase GCN2 against RNA viruses. EMBO J 25, 17301740.
  • 25
    Hao SZ, Sharp JW, Ross-Inta CM, McDaniel BJ, Anthony TG, Wek RC, Cavener DR, McGrath BC, Rudell JB, Koehnle TJ et al. (2005) Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science 307, 17761778.
  • 26
    Alves VS & Castilho BA (2005) Gir2 is an intrinsically unstructured protein that is present in Saccharomyces cerevisiae as a group of heterogeneously electrophoretic migrating forms. Biochem Biophys Res Commun 332, 450455.
  • 27
    Alves VS, Pimenta DC, Sattlegger E & Castilho BA (2004) Biophysical characterization of Gir2, a highly acidic protein of Saccharomyces cerevisiae with anomalous electrophoretic behavior. Biochem Biophys Res Commun 314, 229234.
  • 28
    Kang N, Chen D, Wang L, Duan L, Liu SR, Tang L, Liu QF, Cui LX & He W (2008) Rwdd1, a thymus aging related molecule, is a new member of the intrinsically unstructured protein family. Cell Mol Immunol 5, 333339.
  • 29
    Sikorski RS & Hieter P (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 1927.
  • 30
    Guldener U, Heck S, Fielder T, Beinhauer J & Hegemann J (1996) A new efficient gene disruption cassette for repeated use in budding yeast. Nucleic Acids Res 24, 25192524.
  • 31
    Anderson JT, Paddy MR & Swanson MS (1993) PUB1 is a major nuclear and cytoplasmic polyadenylated RNA-binding protein in Saccharomyces cerevisiae. Mol Cell Biol 13, 61026113.
  • 32
    Vazquez de Aldana CR, Marton MJ & Hinnebusch AG (1995) GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells. EMBO J 14, 31843199.
  • 33
    Visweswaraiah J, Lageix S, Castilho BA, Izotova L, Kinzy TG, Hinnebusch AG & Sattlegger E (2011) Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activity. J Biol Chem 286, 3656836579.
  • 34
    Anand M, Chakraburtty K, Marton MJ, Hinnebusch AG & Kinzy TG (2003) Functional interactions between yeast translation eukaryotic elongation factor (eEF) 1A and eEF3. J Biol Chem 278, 69856991.
  • 35
    Kovalchuke O & Chakraburtty K (1994) Comparative-analysis of ribosome-associated adenosine-triphosphatese (ATPase) from pig-liver and the ATPase of elongation-factor-3 from Saccharomyces cerevisiae. Eur J Biochem 226, 133140.
  • 36
    Dever TE, Wek RC, Feng L, Cigan AM, Donahue TF & Hinnebusch AG (1992) Phosphorylation of initiation factor 2a by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. Cell 68, 585596.
  • 37
    Mulholland J, Preuss D, Moon A, Wong A, Drubin D & Botstein D (1994) Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane. J Cell Biol 125, 381391.
  • 38
    Foiani M, Cigan AM, Paddon CJ, Harashima S & Hinnebusch AG (1991) GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces  cerevisiae. Mol Cell Biol 11, 32033216.