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  • 1
    Putaala H, Soininen R, Kilpelainen P, Wartiovaara J & Tryggvason K (2001) The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death. Hum Mol Genet 10, 18.
  • 2
    Holzman LB, St John PL, Kovari IA, Verma R, Holthofer H & Abrahamson DR (1999) Nephrin localizes to the slit pore of the glomerular epithelial cell. Kidney Int 56, 14811491.
  • 3
    Kestilä M, Lenkkeri U, Männikkö M, Lamerdin J, McCready P, Putaala H, Ruotsalainen V, Morita T, Nissinen M, Herva R et al. (1998) Positionally cloned gene for a novel glomerular protein – nephrin – is mutated in congenital nephrotic syndrome. Mol Cell 1, 575582.
  • 4
    Pavenstadt H, Kriz W & Kretzler M (2003) Cell biology of the glomerular podocyte. Physiol Rev 83, 253307.
  • 5
    Kanda S, Harita Y, Shibagaki Y, Sekine T, Igarashi T, Inoue T & Hattori S (2011) Tyrosine phosphorylation-dependent activation of TRPC6 regulated by PLC-γ1 and nephrin: effect of mutations associated with focal segmental glomerulosclerosis. Mol Biol Cell 22, 18241835.
  • 6
    D’Agati VD, Kaskel FJ & Falk RJ (2011) Focal segmental glomerulosclerosis. N Engl J Med 365, 23982411.
  • 7
    Ozaltin F, Ibsirlioglu T, Taskiran EZ, Baydar DE, Kaymaz F, Buyukcelik M, Kilic BD, Balat A, Iatropoulos P, Asan E et al. (2011) Disruption of PTPRO causes childhood-onset nephrotic syndrome. Am J Hum Genet 89, 139147.
  • 8
    Mucha B, Ozaltin F, Hinkes BG, Hasselbacher K, Ruf RG, Schultheiss M, Hangan D, Hoskins BE, Everding AS, Bogdanovic R et al. (2006) Mutations in the Wilms’ tumor 1 gene cause isolated steroid resistant nephrotic syndrome and occur in exons 8 and 9. Pediatr Res 59, 325331.
  • 9
    Takeda T, McQuistan T, Orlando RA & Farquhar MG (2001) Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton. J Clin Invest 108, 289301.
  • 10
    Benzing T (2004) Signaling at the slit diaphragm. J Am Soc Nephrol 15, 13821391.
  • 11
    Verma R, Wharram B, Kovari I, Kunkel R, Nihalani D, Wary KK, Wiggins RC, Killen P & Holzman LB (2003) Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin. J Biol Chem 278, 2071620723.
  • 12
    Verma R, Kovari I, Soofi A, Nihalani D, Patrie K & Holzman LB (2006) Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization. J Clin Invest 116, 13461359.
  • 13
    Jones N, Blasutig IM, Eremina V, Ruston JM, Bladt F, Li H, Huang H, Larose L, Li SS, Takano T et al. (2006) Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature 440, 818823.
  • 14
    Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, Ohsawa I, Ohta S & Hattori S (2009) Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-gamma 1. J Biol Chem 284, 89518962.
  • 15
    Garg P, Verma R, Nihalani D, Johnstone DB & Holzman LB (2007) Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization. Mol Cell Biol 27, 86988712.
  • 16
    Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T & Hattori S (2008) Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2. J Biol Chem 283, 91779186.
  • 17
    Yu CC, Yen TS, Lowell CA & DeFranco AL (2001) Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn. Curr Biol 11, 3438.
  • 18
    Kurihara H, Harita Y, Ichimura K, Hattori S & Sakai T (2010) SIRP-alpha-CD47 system functions as an intercellular signal in the renal glomerulus. Am J Physiol Renal Physiol 299, F517F527.
  • 19
    Oshima K, Ruhul Amin AR, Suzuki A, Hamaguchi M & Matsuda S (2002) SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett 519, 17.
  • 20
    Barclay AN & Brown MH (2006) The SIRP family of receptors and immune regulation. Nat Rev Immunol 6, 457464.
  • 21
    Matozaki T, Murata Y, Okazawa H & Ohnishi H (2009) Functions and molecular mechanisms of the CD47-SIRPalpha signalling pathway. Trends Cell Biol 19, 7280.
  • 22
    Gardai SJ, Xiao YQ, Dickinson M, Nick JA, Voelker DR, Greene KE & Henson PM (2003) By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell 115, 1323.
  • 23
    Fujioka Y, Matozaki T, Noguchi T, Iwamatsu A, Yamao T, Takahashi N, Tsuda M, Takada T & Kasuga M (1996) A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol Cell Biol 16, 68876899.
  • 24
    Neel BG, Gu H & Pao L (2003) The ‘Shp’ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem Sci 28, 284293.
  • 25
    Schnabel E, Anderson JM & Farquhar MG (1990) The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium. J Cell Biol 111, 12551263.
  • 26
    Luimula P, Ahola H, Wang SX, Solin ML, Aaltonen P, Tikkanen I, Kerjaschki D & Holthöfer H (2000) Nephrin in experimental glomerular disease. Kidney Int 58, 14611468.
  • 27
    Garg P & Holzman LB (2012) Podocytes: gaining a foothold. Exp Cell Res 318, 955963.
  • 28
    Kawachi H, Koike H & Shimizu F (2002) Molecular structure and function of the slit diaphragm: expression of nephrin in proteinuric states and in developing glomeruli. Nephrol Dial Transplant 17(Suppl 9), 2022.
  • 29
    Huber TB, Hartleben B, Winkelmann K, Schneider L, Becker JU, Leitges M, Walz G, Haller H & Schiffer M (2009) Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome. J Am Soc Nephrol 20, 798806.
  • 30
    Liu L, Doné SC, Khoshnoodi J, Bertorello A, Wartiovaara J, Berggren PO & Tryggvason K (2001) Defective nephrin trafficking caused by missense mutations in the NPHS1 gene: insight into the mechanisms of congenital nephrotic syndrome. Hum Mol Genet 10, 26372644.
  • 31
    Ohnishi H, Yamada M, Kubota M, Hatanaka H & Sano S (1999) Tyrosine phosphorylation and association of BIT with SHP-2 induced by neurotrophins. J Neurochem 72, 14021408.
  • 32
    Okazawa H, Motegi S, Ohyama N, Ohnishi H, Tomizawa T, Kaneko Y, Oldenborg PA, Ishikawa O & Matozaki T (2005) Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system. J Immunol 174, 20042011.
  • 33
    Araki T, Yamada M, Ohnishi H, Sano SI & Hatanaka H (2000) BIT/SHPS-1 enhances brain-derived neurotrophic factor-promoted neuronal survival in cultured cerebral cortical neurons. J Neurochem 75, 15021510.
  • 34
    Kharitonenkov A, Chen Z, Sures I, Wang H, Schilling J & Ullrich A (1997) A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 386, 181186.
  • 35
    Reiser J, Pixley FJ, Hug A, Kriz W, Smoyer WE, Stanley ER & Mundel P (2000) Regulation of mouse podocyte process dynamics by protein tyrosine phosphatases rapid communication. Kidney Int 57, 20352042.
  • 36
    Aoudjit L, Jiang R, Lee TH, New LA, Jones N & Takano T (2011) Podocyte protein, nephrin, is a substrate of protein tyrosine phosphatase 1B. J Signal Transduct 2011, 376543. doi:10.1155/2011/376543.
  • 37
    Tezuka T, Umemori H, Akiyama T, Nakanishi S & Yamamoto T (1999) PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A. Proc Natl Acad Sci USA 96, 435440.
  • 38
    Hisatsune C, Kuroda Y, Nakamura K, Inoue T, Nakamura T, Michikawa T, Mizutani A & Mikoshiba K (2004) Regulation of TRPC6 channel activity by tyrosine phosphorylation. J Biol Chem 279, 1888718894.