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Fig. S1. Sequence alignment between the amino acid sequences of the ligand-binding domains of the umami T1R1 subunit and the metabotropic glutamate receptor mGluR1.

Fig. S2. Snapshot of the starting conformations for Movie S1 (simulation NOGlu1).

Fig. S3. Snapshot of the starting conformations for Movie S2 (simulation Glu1).

Fig. S4. Snapshot of the starting conformations for Movie S3 (simulation GMPGlu1).

Movies S1, S2 and S3. Animations showing interpolation between the extreme conformations sampled by the trajectory of NOGlu1, Glu1 and GMPGlu1 projected upon the first eigenvector of the covariance matrix of the backbone heavy atoms.

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