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Fig. S1. Length distribution of six runs and 100 000 calculated substrate cycles by EFMEvolver.

Table S1. The 100 shortest substrate cycles calculated with the K-shortest EFM method.

Table S2. Further information for the substrate cycles shown in Fig. 2.

Table S3. All substrate cycles occurring in the nucleus.

Table S4. All substrate cycles occurring in the mitochondrion.

Table S5. The chemical formulas of the deleted reactions described in the Materials and methods.

Model S1. Human genome-scale metabolic model containing the changes described in the Materials and methods.

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