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HuPho: the human phosphatase portal

  1. Susanna Liberti1,
  2. Francesca Sacco1,
  3. Alberto Calderone1,
  4. Livia Perfetto1,
  5. Marta Iannuccelli1,
  6. Simona Panni1,2,
  7. Elena Santonico1,
  8. Anita Palma1,
  9. Aurelio P. Nardozza1,
  10. Luisa Castagnoli1,
  11. Gianni Cesareni1,3

Article first published online: 24 AUG 2012

DOI: 10.1111/j.1742-4658.2012.08712.x

Issue

FEBS Journal

FEBS Journal

Special Issue: Protein Phosphatases: From Molecules to Networks

Volume 280, Issue 2, pages 379–387, January 2013

Additional Information

How to Cite

Liberti, S., Sacco, F., Calderone, A., Perfetto, L., Iannuccelli, M., Panni, S., Santonico, E., Palma, A., Nardozza, A. P., Castagnoli, L. and Cesareni, G. (2013), HuPho: the human phosphatase portal. FEBS Journal, 280: 379–387. doi: 10.1111/j.1742-4658.2012.08712.x

Author Information

  1. 1

     Department of Biology, University of Rome ‘Tor Vergata’, Italy

  2. 2

     Department of Cell Biology, University of Calabria, Rende, Italy

  3. 3

     Research Institute ‘Fondazione Santa Lucia’, Rome, Italy

*S. Liberti, Department of Biology, University of Rome ‘Tor Vergata’, Rome, Italy Fax: +39 062023500 Tel: +39 06725 94315 E-mail: susanna.liberti@gmail.com

Publication History

  1. Issue published online: 22 JAN 2013
  2. Article first published online: 24 AUG 2012
  3. Accepted manuscript online: 16 JUL 2012 12:07PM EST
  4. (Received 28 March 2012, revised 4 July 2012, accepted 11 July 2012)

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Keywords:

  • database;
  • phosphatase substrates;
  • phosphatases;
  • phosphorylation;
  • protein interaction

Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. Phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Thus, a comprehensive picture of phosphatase function and the identification of their target substrates would aid a systematic approach to a mechanistic description of cell signalling. Here we present a website designed to facilitate the retrieval of information about human protein phosphatases. To this end we developed a search engine to recover and integrate information annotated in several publicly available web resources. In addition we present a text-mining-assisted annotation effort aimed at extracting phosphatase related data reported in the scientific literature. The HuPho (human phosphatases) website can be accessed at http://hupho.uniroma2.it.

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