Both authors contributed equally to this work.
Effect of oxidised regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration
Article first published online: 20 MAY 2008
© 2008 The Authors. Journal Compilation © 2008 Blackwell Publishing Ltd and Medicalhelplines.com Inc
International Wound Journal
Volume 5, Issue 2, pages 195–203, May 2008
How to Cite
Smeets, R., Ulrich, D., Unglaub, F., Wöltje, M. and Pallua, N. (2008), Effect of oxidised regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. International Wound Journal, 5: 195–203. doi: 10.1111/j.1742-481X.2007.00367.x
- Issue published online: 20 MAY 2008
- Article first published online: 20 MAY 2008
- Chronic venous ulcers;
- Wound healing
Oxidised regenerated cellulose/collagen matrix (ORC/collagen matrix) modifies wound microenvironments by binding and inactivating excess levels of proteases such as elastase, plasmin and gelatinases in wound exudates. To compare levels of the gelatinases matrix metalloproteinase 2 (MMP-2), elastase and plasmin in wound exudates collected from chronic venous insufficiency patients with venous leg ulcers treated with either an ORC/collagen matrix or a standard control therapy. During a 12-week treatment period, wound exudate samples were obtained from a control group of 10 patients treated with a hydrocolloid dressing and a treatment group of 17 patients treated with a combination of ORC/collagen matrix and hydrocolloid dressing. On admission and days 5, 14 and every subsequent 14th day, ulcers were photographed to determine healing rate and changes in ulcer appearance, and MMP-2 concentration and the gelatinase, elastase and plasmin activities were analysed from wound exudates. The patients treated with ORC/collagen matrix showed a significant decrease in elastase, plasmin and gelastinase activity as compared with the control group, with no significant difference in the MMP-2 concentrations between the two groups. The results show a significant and immediate reduction in protease activity in wound exudates from venous leg ulcers treated with ORC/collagen.