• 1
    Cervero F. Sensory innervation of the viscera: peripheral basis of visceral pain. Physiol Rev 1994; 74: 95138.
  • 2
    Al-Chaer ED, Lawand NB, Westlund KN, Willis WD. Visceral nociceptive input into the ventral posterolateral nucleus of the thalamus. a new function for the dorsal column pathway. J Neurophysiol 1996; 76: 266174.
  • 3
    Van Der Kooy D, Koda LY, McGinty JF, Gerfen CR, Bloom FE. The organization of projections from the cortex, amygdala, and hypothalamus to the nucleus of the solitary tract in rat. J Comp Neurol 1984; 224: 124.
  • 4
    Berthoud HR, Neuhuber WL. Functional and chemical anatomy of the afferent vagal system. Auton Neurosci 2000; 85: 117.
  • 5
    Powley TL, Phillips RJ. Musings on the wanderer: what's new in our understanding of vago-vagal reflexes? I. Morphology and topography of vagal afferents innervating the GI tract. Am J Physiol Gastrointest Liver Physiol 2002; 283: G121725.
  • 6
    Tassicker BC, Hennig GW, Costa M, Brookes SJ. Rapid anterograde and retrograde tracing from mesenteric nerve trunks to the guinea-pig small intestine in vitro. Cell Tissue Res 1999; 295: 43752.
  • 7
    Zagorodnyuk VP, Chen BN, Brookes SJ. Intraganglionic laminar endings are mechano-transduction sites of vagal tension receptors in the guinea-pig stomach. J Physiol 2001; 534: 25568.
  • 8
    Zagorodnyuk VP, Brookes SJ. Transduction sites of vagal mechanoreceptors in the guinea pig esophagus. J Neurosci 2000; 20: 624955.
  • 9
    Lynn PA, Olsson C, Zagorodnyuk V, Costa M, Brookes SJ. Rectal intraganglionic laminar endings are transduction sites of extrinsic mechanoreceptors in the guinea pig rectum. Gastroenterology 2003; 125: 78694.
  • 10
    Berthoud HR, Powley TL. Vagal afferent innervation of the rat fundic stomach: morphological characterization of the gastric tension receptor. J Comp Neurol 1992; 319: 26176.
  • 11
    Kressel M, Berthoud HR, Neuhuber WL. Vagal innervation of the rat pylorus: an anterograde tracing study using carbocyanine dyes and laser scanning confocal microscopy. Cell Tissue Res 1994; 275: 10923.
  • 12
    Fox EA, Phillips RJ, Martinson FA, Baronowsky EA, Powley TL. Vagal afferent innervation of smooth muscle in the stomach and duodenum of the mouse. morphology and topography. J Comp Neurol 2000; 428: 55876.
  • 13
    Wang FB, Powley TL. Topographic inventories of vagal afferents in gastrointestinal muscle. J Comp Neurol 2000; 421: 30224.
  • 14
    Berthoud HR, Patterson LM, Neumann F, Neuhuber WL. Distribution and structure of vagal afferent intraganglionic laminar endings (IGLEs) in the rat gastrointestinal tract. Anat Embryol (Berl) 1997; 195: 18391.
  • 15
    Berthoud HR, Kressel M, Raybould HE, Neuhuber WL. Vagal sensors in the rat duodenal mucosa: distribution and structure as revealed by in vivo DiI-tracing. Anat Embryol (Berl) 1995; 191: 20312.
  • 16
    Berthoud HR, Patterson LM. Anatomical relationship between vagal afferent fibers and CCK-immunoreactive entero-endocrine cells in the rat small intestinal mucosa. Acta Anat (Basel) 1996; 156: 12331.
  • 17
    Williams RM, Berthoud HR, Stead RH. Vagal afferent nerve fibres contact mast cells in rat small intestinal mucosa. Neuroimmunomodulation 1997; 4: 26670.
  • 18
    Ward SM, Bayguinov J, Won KJ, Grundy D, Berthoud HR. Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract. J Comp Neurol 2003; 465: 12135.
  • 19
    Grundy D. Neuroanatomy of visceral nociception: vagal and splanchnic afferent. Gut 2002; 51(Suppl. 1): i2–5.
  • 20
    Lynn PA, Blackshaw LA. In vitro recordings of afferent fibres with receptive fields in the serosa, muscle and mucosa of rat colon. J Physiol 1999; 518: 27182.
  • 21
    Blackshaw LA, Gebhart GF. The pharmacology of gastrointestinal nociceptive pathways. Curr Opin Pharmacol 2002; 2: 6429.
  • 22
    Blumberg H, Haupt P, Janig W, Kohler W. Encoding of visceral noxious stimuli in the discharge patterns of visceral afferent fibres from the colon. Pflugers Arch 1983; 398: 3340.
  • 23
    Blackshaw LA, Grundy D, Scratcherd T. Vagal afferent discharge from gastric mechanoreceptors during contraction and relaxation of the ferret corpus. J Auton Nerv Syst 1987; 18: 1924.
  • 24
    Cottrell DF. Tension receptors with vagal afferent fibres in the proximal duodenum and pyloric sphincter of sheep. J Physiol 1984; 354: 45775.
  • 25
    Iggo A. Tension receptors in the stomach and urinary bladder. J Physiol 1955; 128: 593607.
  • 26
    Janig W, Koltzenburg M. On the function of spinal primary afferent fibres supplying colon and urinary bladder. J Auton Nerv Syst 1990; 30: S8996.
  • 27
    Cottrell D, Iggo A. Mucosal enteroceptors with vagal afferent fibres in the proximal duodenum of sheep. J Physiol 1984; 354: 497522.
  • 28
    Davison JS. Response of single vagal afferent fibres to mechanical and chemical stimulation of the gastric and duodenal mucosa in cats. Q J Exp Physiol 1972; 57: 40516.
  • 29
    Iggo A. Gastric mucosal chemoreceptors with vagal afferent fibres in the cat. Q J Exp Physiol 1957; 42: 399409.
  • 30
    Fox EA, Phillips RJ, Byerly MS, Baronowsky EA, Chi MM, Powley TL. Selective loss of vagal intramuscular mechanoreceptors in mice mutant for steel factor, the c-Kit receptor ligand. Anat Embryol (Berl) 2002; 205: 32542.
  • 31
    Fox EA, Phillips RJ, Martinson FA, Baronowsky EA, Powley TL. c-Kit mutant mice have a selective loss of vagal intramuscular mechanoreceptors in the forestomach. Anat Embryol (Berl) 2001; 204: 1126.
  • 32
    Rodrigo J, Hernandez J, Vidal MA, Pedrosa JA. Vegetative innervation of the esophagus. II. Intraganglionic laminar endings. Acta Anat (Basel) 1975; 92: 79100.
  • 33
    Neuhuber WL. Sensory vagal innervation of the rat esophagus and cardia. a light and electron microscopic anterograde tracing study. J Auton Nerv Syst 1987; 20: 24355.
  • 34
    Kirkup AJ, Brunsden AM, Grundy D. Receptors and transmission in the brain–gut axis: potential for novel therapies. I. Receptors on visceral afferents. Am J Physiol Gastrointest Liver Physiol 2001; 280: G78794.
  • 35
    Blackshaw LA, Grundy D. Effects of 5-hydroxytryptamine on discharge of vagal mucosal afferent fibres from the upper gastrointestinal tract of the ferret. J Auton Nerv Syst 1993; 45: 4150.
  • 36
    Hicks GA, Coldwell JR, Schindler M et al. Excitation of rat colonic afferent fibres by 5-HT3 receptors. J Physiol 2002; 544: 8619.
  • 37
    Berthoud HR, Lynn PA, Blackshaw LA. Vagal and spinal mechanosensors in the rat stomach and colon have multiple receptive fields. Am J Physiol Reg Integ Physiol 2001; 280: R1371R1381.
  • 38
    Coldwell JR, Blackshaw LA. Colonic lumbar splanchnic afferents respond to histamine. Gastroenterology 2002; 122: A528A528.
  • 39
    Booth CE, Kirkup AJ, Hicks GA, Humphrey PP, Grundy D. Somatostatin sst(2) receptor-mediated inhibition of mesenteric afferent nerves of the jejunum in the anesthetized rat. Gastroenterology 2001; 121: 35869.