Intracavernous Sodium Nitroprusside (SNP) versus Papaverine/Phentolamine in Erectile Dysfunction: A Comparative Study of Short-Term Efficacy and Side-Effects
Article first published online: 6 JAN 2005
The Journal of Sexual Medicine
Volume 2, Issue 1, pages 117–120, January 2005
How to Cite
Shamloul, R., Atteya, A., Elnashaar, A., Gadallah, A., Zohdy, W. and Abdelsalam, W. (2005), Intracavernous Sodium Nitroprusside (SNP) versus Papaverine/Phentolamine in Erectile Dysfunction: A Comparative Study of Short-Term Efficacy and Side-Effects. Journal of Sexual Medicine, 2: 117–120. doi: 10.1111/j.1743-6109.2005.20121.x
- Issue published online: 6 JAN 2005
- Article first published online: 6 JAN 2005
- Sodium Nitroprusside;
- Intracavernous Drugs
Objective. The aim of our work is to evaluate the efficacy of intracavernous sodium nitroprusside (SNP) in management of erectile dysfunction (ED) in a clinical comparative study with papaverine/phentolamine in ED patients.
Methods. The study included 40 patients with ED divided into two groups. Group I include 20 patients receiving intracavernous (30 mg papaverine + 1 mg phentolamine) followed 1 week later by intracavernous 300 µg SNP. Group II included 20 patients receiving the same regimen of group I but with intracavernous SNP first followed by papaverine/phentolamine 1 week later. All patients were assessed clinically for their response and any developing complications.
Results. The numbers of good and poor responders were not statistically significant (P > 0.05) among the two groups. The mean erectile duration of SNP was similar to bimix (P > 0.05). No side-effects whether local or systemic occurred with SNP while priapism and local penile pain were recorded with bimix solution.
Conclusions. Intracavernous pharmacotherapy is still a reliable method both for diagnosis and for treatment of ED. While preliminary results of our study show a potential of SNP to be an effective and safe intracavernous agent, long-term self-injection clinical trials are needed before large-scale usage is recommended.