Effect of the 5-HT2A/2C Receptor Agonist DOI on Female Rat Sexual Behavior

Authors

  • Anne-Sophie Rössler PhD,

    1. Pelvipharm Laboratories, CNRS, Gif-sur-Yvette, France;
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  • Jacque Bernabé PhD,

    1. Pelvipharm Laboratories, CNRS, Gif-sur-Yvette, France;
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  • Pierre Denys MD, PhD,

    1. Neuro-Urology Unit, Department of Neurological Rehabilitation, AP-HP, Raymond Poincaré Hospital, Garches, France
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  • Laurent Alexandre MD,

    1. Pelvipharm Laboratories, CNRS, Gif-sur-Yvette, France;
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  • François Giuliano MD, PhD

    Corresponding author
    1. Pelvipharm Laboratories, CNRS, Gif-sur-Yvette, France;
    2. Neuro-Urology Unit, Department of Neurological Rehabilitation, AP-HP, Raymond Poincaré Hospital, Garches, France
      François Giuliano, Neuro-Urology Unit, Department of Neurological Rehabilitation, Raymond Poincaré Hospital, 104 bd Raymond Poincaré, 92380 Garches, France. Tel: 33 1 47 10 70 72; Fax: 33 1 47 10 76 15; E-mail: giuliano@cyber-sante.org
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François Giuliano, Neuro-Urology Unit, Department of Neurological Rehabilitation, Raymond Poincaré Hospital, 104 bd Raymond Poincaré, 92380 Garches, France. Tel: 33 1 47 10 70 72; Fax: 33 1 47 10 76 15; E-mail: giuliano@cyber-sante.org

ABSTRACT

Introduction.  Female rats display a repertoire of behaviors during a sexual encounter with a male, including sexually receptive (the lordosis response) and proceptive (darts and hops, and ear wigglings) behaviors.

Aim.  We investigated the effects of subcutaneous injection of the 5-HT2A/2C receptor agonist (2,5-dimethoxy-4-idophenyl)-2-aminopropane hydrochloride (DOI) on sexual behaviors of ovariectomized female rat hormonally supplemented with estradiol benzoate (10 µg) and progesterone (250 µg).

Methods.  Both female and male sexual behaviors were observed for 10 minutes (pretest). Then females were injected with the treatment and after a 10-minute delay replaced with the same male for a 30-minute mating test (posttreatment period).

Results.  DOI (0.5 and 1 mg/kg) significantly increased the number of darts and hops/mounts. In contrast, no significant differences in ear wigglings/mounts were observed. In addition, DOI failed to modify sexual receptivity.

Conclusion.  These data suggest that 5-HT2A/2C receptors are important in the regulation of female proceptivity. Rössler A-S, Bernabé J, Denys P, Alexandre L, and Giuliano F. Effect of the 5-HT2A/2C receptor agonist DOI on female rat sexual behavior.J Sex Med 2006;3:432–441.

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