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References

  • 1
    Waldinger MD, Zwinderman AH, Schweitzer DH, Olivier B. Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: A systematic review and meta-analysis. Int J Impot Res 2004;16:36981.
  • 2
    Waldinger MD, Hengeveld MW, Zwinderman AH, Olivier B. Effect of SSRI antidepressants on ejaculation: A double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline. J Clin Psychopharmacol 1998;18:27481.
  • 3
    Waldinger MD, Van De Plas A, Pattij T, Van Oorschot R, Coolen LM, Veening JG, Olivier B. The selective serotonin re-uptake inhibitors fluvoxamine and paroxetine differ in sexual inhibitory effects after chronic treatment. Psychopharmacology (Berl) 2002;160:2839.
  • 4
    Olivier B, Chan JS, Pattij T, De Jong TR, Oosting RS, Veening JG, Waldinger MD. Psychopharmacology of male rat sexual behavior: Modeling human sexual dysfunctions? Int J Impot Res 2006;18(Suppl 1):S1423.
  • 5
    Waldinger MD. Emerging drugs for premature ejaculation. Expert Opin Emerg Drugs 2006;11: 99109.
  • 6
    Waldinger MD. Overview of premature and retarded ejaculation. Eur Urol Today 2005;17:202.
  • 7
    Nutt DJ, Forshall S, Bell C, Rich A, Sandford J, Nash J, Argyropoulos S. Mechanisms of action of selective serotonin reuptake inhibitors in the treatment of psychiatric disorders. Eur Neuropsychopharmacol 1999;9(suppl 3):S816.
  • 8
    Bymaster FP, Zhang W, Carter PA, Shaw J, Chernet E, Phebus L, Wong DT, Perry KW. Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berl) 2002;160:35361.
  • 9
    Felton TM, Kang TB, Hjorth S, Auerbach SB. Effects of selective serotonin and serotonin/noradrenaline reuptake inhibitors on extracellular serotonin in rat diencephalon and frontal cortex. Naunyn Schmiedebergs Arch Pharmacol 2003; 367:297305.
  • 10
    Hjorth S, Auerbach SB. Autoreceptors remain functional after prolonged treatment with a serotonin reuptake inhibitor. Brain Res 1999;835:2248.
  • 11
    Bosker FJ, Klompmakers AA, Westenberg HG. Effects of single and repeated oral administration of fluvoxamine on extracellular serotonin in the median raphe nucleus and dorsal hippocampus of the rat. Neuropharmacology 1995;34:5018.
  • 12
    Koch S, Perry KW, Bymaster FP. Brain region and dose effects of an olanzapine/fluoxetine combination on extracellular monoamine concentrations in the rat. Neuropharmacology 2004;46:23242.
  • 13
    Malagie I, Trillat AC, Jacquot C, Gardier AM. Effects of acute fluoxetine on extracellular serotonin levels in the raphe: An in vivo microdialysis study. Eur J Pharmacol 1995;286:2137.
  • 14
    Romero L, Artigas F. Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: Role of somatodendritic autoreceptors. J Neurochem 1997;68:2593603.
  • 15
    Page ME, Detke MJ, Dalvi A, Kirby LG, Lucki I. Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test. Psychopharmacology (Berl) 1999;147:1627.
  • 16
    Ressler KJ, Nemeroff CB. Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress Anxiety 2000;12(suppl 1):219.
  • 17
    Van Der Stelt HM, Breuer ME, Olivier B, Westenberg HG. Permanent deficits in serotonergic functioning of olfactory bulbectomized rats: An in vivo microdialysis study. Biol Psychiatry 2005;57:10617.
  • 18
    Artigas F. Limitations to enhancing the speed of onset of antidepressants—Are rapid action antidepressants possible? Hum Psychopharmacol 2001;16:2936.
  • 19
    Katz MM, Tekell JL, Bowden CL, Brannan S, Houston JP, Berman N, Frazer A. Onset and early behavioral effects of pharmacologically different antidepressants and placebo in depression. Neuropsychopharmacology 2004;29:56679.
  • 20
    Newman ME, Shalom G, Ran A, Gur E, Van de Kar LD. Chronic fluoxetine-induced desensitization of 5-HT1A and 5-HT1B autoreceptors: Regional differences and effects of WAY-100635. Eur J Pharmacol 2004;486:2530.
  • 21
    Le Poul E, Boni C, Hanoun N, Laporte AM, Laaris N, Chauveau J, Hamon M, Lanfumey L. Differential adaptation of brain 5-HT1A and 5-HT1B receptors and 5-HT transporter in rats treated chronically with fluoxetine. Neuropharmacology 2000;39:11022.
  • 22
    Hensler JG. Regulation of 5-HT1A receptor function in brain following agonist or antidepressant administration. Life Sci 2003;72:166582.
  • 23
    Pineyro G, Blier P. Autoregulation of serotonin neurons: Role in antidepressant drug action. Pharmacol Rev 1999;51:53391.
  • 24
    Elena Castro M, Diaz A, Del Olmo E, Pazos A. Chronic fluoxetine induces opposite changes in G protein coupling at pre and postsynaptic 5-HT1A receptors in rat brain. Neuropharmacology 2003;44:93101.
  • 25
    Invernizzi R, Bramante M, Samanin R. Role of 5-HT1A receptors in the effects of acute chronic fluoxetine on extracellular serotonin in the frontal cortex. Pharmacol Biochem Behav 1996;54:1437.
  • 26
    Blier P, Pineyro G, El Mansari M, Bergeron R, De Montigny C. Role of somatodendritic 5-HT autoreceptors in modulating 5-HT neurotransmission. Ann NY Acad Sci 1998;861:20416.
  • 27
    Ahlenius S, Larsson K. Opposite effects of 5-methoxy-N,N-di-methyl-tryptamine and 5-hydroxytryptophan on male rat sexual behavior. Pharmacol Biochem Behav 1991;38:2015.
  • 28
    Ahlenius S, Larsson K. Antagonism by lisuride and 8-OH-DPAT of 5-HTP-induced prolongation of the performance of male rat sexual behavior. Eur J Pharmacol 1985;110:37981.
  • 29
    Ahlenius S, Larsson K. Evidence for an involvement of 5-HT1B receptors in the inhibition of male rat ejaculatory behavior produced by 5-HTP. Psychopharmacology (Berl) 1998;137:37482.
  • 30
    Ahlenius S, Larsson K. Failure to antagonize the 8-hydroxy-2-(di-n-propylamino) tetralin-induced facilitation of male rat sexual behavior by the administration of 5-HT receptor antagonists. Eur J Pharmacol 1984;99:27986.
  • 31
    Ahlenius S, Larsson K, Svensson L. Further evidence for an inhibitory role of central 5-HT in male rat sexual behavior. Psychopharmacology (Berl) 1980;68:21720.
  • 32
    Hillegaart V, Ahlenius S, Larsson K. Region-selective inhibition of male rat sexual behavior and motor performance by localized forebrain 5-HT injections: A comparison with effects produced by 8-OH-DPAT. Behav Brain Res 1991; 42:16980.
  • 33
    Fernandez-Guasti A, Escalante AL, Ahlenius S, Hillegaart V, Larsson K. Stimulation of 5-HT1A and 5-HT1B receptors in brain regions and its effects on male rat sexual behaviour. Eur J Pharmacol 1992;210:1219.
  • 34
    Hillegaart V, Ahlenius S. Facilitation and inhibition of male rat ejaculatory behaviour by the respective 5-HT1A and 5-HT1B receptor agonists 8-OH-DPAT and anpirtoline, as evidenced by use of the corresponding new and selective receptor antagonists NAD-299 and NAS-181. Br J Pharmacol 1998;125:173343.
  • 35
    Fernandez-Guasti A, Rodriguez-Manzo G. Further evidence showing that the inhibitory action of serotonin on rat masculine sexual behavior is mediated after the stimulation of 5-HT1B receptors. Pharmacol Biochem Behav 1992;42:52933.
  • 36
    Mendelson SD, Gorzalka BB. Sex differences in the effects of 1-(m-trifluoromethylphenyl) piperazine and 1-(m-chlorophenyl) piperazine on copulatory behavior in the rat. Neuropharmacology 1990;29:7836.
  • 37
    Pomerantz SM, Hepner BC, Wertz JM. 5-HT1A and 5-HT1C/1D receptor agonists produce reciprocal effects on male sexual behavior of rhesus monkeys. Eur J Pharmacol 1993;243:22734.
  • 38
    Yells DP, Prendergast MA, Hendricks SE, Nakamura M. Fluoxetine-induced inhibition of male rat copulatory behavior: Modification by lesions of the nucleus paragigantocellularis. Pharmacol Biochem Behav 1994;49:1217.
  • 39
    Mos J, Mollet I, Tolboom JT, Waldinger MD, Olivier B. A comparison of the effects of different serotonin reuptake blockers on sexual behaviour of the male rat. Eur Neuropsychopharmacol 1999; 9:12335.
  • 40
    Cantor JM, Binik YM, Pfaus JG. Chronic fluoxetine inhibits sexual behavior in the male rat: Reversal with oxytocin. Psychopharmacology (Berl) 1999;144:35562.
  • 41
    De Jong TR, Pattij T, Veening JG, Waldinger MD, Cools AR, Olivier B. Effects of chronic selective serotonin reuptake inhibitors on 8-OH-DPAT-induced facilitation of ejaculation in rats: Comparison of fluvoxamine and paroxetine. Psychopharmacology (Berl) 2005;179:50915.
  • 42
    Vega MJ, Larsson K, Eriksson E. The selective serotonin reuptake inhibitor fluoxetine reduces sexual motivation in male rats. Pharmacol Biochem Behav 1998;60:52732.
  • 43
    Waldinger MD, Zwinderman AH, Olivier B. On-demand treatment of premature ejaculation with clomipramine and paroxetine: A randomized, double-blind fixed-dose study with stopwatch assessment. Eur Urol 2004;46:5105;discussion 516.
  • 44
    Waldinger MD, Zwinderman AH, Olivier B. SSRIs and ejaculation: A double-blind, randomized, fixed-dose study with paroxetine and citalopram. J Clin Psychopharmacol 2001;21:55660.
  • 45
    Hellstrom W, Sharlip I, Miloslavsky M. Efficacy of dapoxetine in men self-rated very poor control over ejaculation. J Urol 2006;175:297.
  • 46
    Invernizzi R, Velasco C, Bramante M, Longo A, Samanin R. Effect of 5-HT1A receptor antagonists on citalopram-induced increase in extracellular serotonin in the frontal cortex, striatum and dorsal hippocampus. Neuropharmacology 1997;36:46773.
  • 47
    Blier P. Pharmacology of rapid-onset antidepressant treatment strategies. J Clin Psychiatry 2001; 62(suppl 15):127.
  • 48
    Artigas F, Romero L, De Montigny C, Blier P. Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists. Trends Neurosci 1996;19:37883.
  • 49
    De Jong TR, Pattij T, Veening JG, Dederen PJ, Waldinger MD, Cools AR, Olivier B. Citalopram combined with WAY 100635 inhibits ejaculation and ejaculation-related Fos immunoreactivity. Eur J Pharmacol 2005;509:4959.
  • 50
    Ahlenius S, Larsson K. Synergistic actions of the 5-HT1A receptor antagonist WAY-100635 and citalopram on male rat ejaculatory behavior. Eur J Pharmacol 1999;379:16.
  • 51
    Ahlenius S, Larsson K, Svensson L, Hjorth S, Carlsson A, Lindberg P, Wikstrom H, Sanchez D, Arvidsson LE, Hacksell U, Nilsson JL. Effects of a new type of 5-HT receptor agonist on male rat sexual behavior. Pharmacol Biochem Behav 1981;15:78592.
  • 52
    Coolen LM, Olivier B, Peters HJ, Veening JG. Demonstration of ejaculation-induced neural activity in the male rat brain using 5-HT1A agonist 8-OH-DPAT. Physiol Behav 1997;62:88191.
  • 53
    Haensel SM, Slob AK. Flesinoxan: A prosexual drug for male rats. Eur J Pharmacol 1997;330:19.
  • 54
    Le Poul E, Laaris N, Doucet E, Laporte AM, Hamon M, Lanfumey L. Early desensitization of somato-dendritic 5-HT1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn Schmiedebergs Arch Pharmacol 1995;352:1418.
  • 55
    Rutter JJ, Gundlah C, Auerbach SB. Increase in extracellular serotonin produced by uptake inhibitors is enhanced after chronic treatment with fluoxetine. Neurosci Lett 1994;171:1836.
  • 56
    Davidson C, Stamford JA. Contrasting effects of chronic paroxetine on 5-HT1A control of dorsal raphe cell firing and 5-HT release. Neuroreport 1998;9:25358.
  • 57
    Czachura JF, Rasmussen K. Effects of acute and chronic administration of fluoxetine on the activity of serotonergic neurons in the dorsal raphe nucleus of the rat. Naunyn Schmiedebergs Arch Pharmacol 2000;362:26675.
  • 58
    Hjorth S, Auerbach SB. Lack of 5-HT1A autoreceptor desensitization following chronic citalopram treatment, as determined by in vivo microdialysis. Neuropharmacology 1994;33:3314.
  • 59
    Bosker FJ, Van Esseveldt KE, Klompmakers AA, Westenberg HG. Chronic treatment with fluvoxamine by osmotic minipumps fails to induce persistent functional changes in central 5-HT1A and 5-HT1B receptors, as measured by in vivo microdialysis in dorsal hippocampus of conscious rats. Psychopharmacology (Berl) 1995;117:35863.
  • 60
    Ludwig M, Leng G. Dendritic peptide release and peptide-dependent behaviours. Nat Rev Neurosci 2006;7:12636.
  • 61
    Landgraf R, Neumann ID. Vasopressin and oxytocin release within the brain: A dynamic concept of multiple and variable modes of neuropeptide communication. Front Neuroendocrinol 2004;25:15076.
  • 62
    Hallbeck M, Larhammar D, Blomqvist A. Neuropeptide expression in rat paraventricular hypothalamic neurons that project to the spinal cord. J Comp Neurol 2001;433:22238.
  • 63
    De Wied D, Diamant M, Fodor M. Central nervous system effects of the neurohypophyseal hormones and related peptides. Front Neuroendocrinol 1993;14:251302.
  • 64
    Raggenbass M. Vasopressin- and oxytocin-induced activity in the central nervous system: Electrophysiological studies using in-vitro systems. Prog Neurobiol 2001;64:30726.
  • 65
    Swanson LW. Cerebral hemisphere regulation of motivated behavior. Brain Res 2000;886:11364.
  • 66
    Larsen PJ, Hay-Schmidt A, Vrang N, Mikkelsen JD. Origin of projections from the midbrain raphe nuclei to the hypothalamic paraventricular nucleus in the rat: A combined retrograde and anterograde tracing study. Neuroscience 1996;70:96388.
  • 67
    Sawchenko PE, Swanson LW, Steinbusch HW, Verhofstad AA. The distribution and cells of origin of serotonergic inputs to the paraventricular and supraoptic nuclei of the rat. Brain Res 1983;277: 35560.
  • 68
    Ju G, Duan XJ, Zhang X. Serotonin-like immunoreactive fibers in the medial dorsal accessory group and the anterior fornical nucleus of the magnocellular neurosecretory system in the rat. Neurosci Lett 1988;93:1922.
  • 69
    Jorgensen H, Riis M, Knigge U, Kjaer A, Warberg J. Serotonin receptors involved in vasopressin and oxytocin secretion. J Neuroendocrinol 2003;15:2429.
  • 70
    Saydoff JA, Rittenhouse PA, Van De Kar LD, Brownfield MS. Enhanced serotonergic transmission stimulates oxytocin secretion in conscious male rats. J Pharmacol Exp Ther 1991;257:959.
  • 71
    Van de Kar LD, Rittenhouse PA, Li Q, Levy AD, Brownfield MS. Hypothalamic paraventricular, but not supraoptic neurons, mediate the serotonergic stimulation of oxytocin secretion. Brain Res Bull 1995;36:4550.
  • 72
    Javed A, Kamradt MC, Van de Kar LD, Gray TS. D-Fenfluramine induces serotonin-mediated Fos expression in corticotropin-releasing factor and oxytocin neurons of the hypothalamus, and serotonin-independent Fos expression in enkephalin and neurotensin neurons of the amygdala. Neuroscience 1999;90:8518.
  • 73
    Mikkelsen JD, Jensen JB, Engelbrecht T, Mork A. d-fenfluramine activates rat oxytocinergic and vasopressinergic neurons through different mechanisms. Brain Res 1999;851:24751.
  • 74
    Van de Kar LD, Javed A, Zhang Y, Serres F, Raap DK, Gray TS. 5-HT2A receptors stimulate ACTH, corticosterone, oxytocin, renin, and prolactin release and activate hypothalamic CRF and oxytocin-expressing cells. J Neurosci 2001;21: 35729.
  • 75
    Jorgensen H, Kjaer A, Knigge U, Moller M, Warberg J. Serotonin stimulates hypothalamic mRNA expression and local release of neurohypophysial peptides. J Neuroendocrinol 2003;15:56471.
  • 76
    Bagdy G. Role of the hypothalamic paraventricular nucleus in 5-HT1A, 5-HT2A and 5-HT2C receptor-mediated oxytocin, prolactin and ACTH/corticosterone responses. Behav Brain Res 1996;73:27780.
  • 77
    Zhang Y, Gray TS, D’Souza DN, Carrasco GA, Damjanoska KJ, Dudas B, Garcia F, Zainelli GM, Sullivan Hanley NR, Battaglia G, Muma NA, Van De Kar LD. Desensitization of 5-HT1A receptors by 5-HT2A receptors in neuroendocrine neurons in vivo. J Pharmacol Exp Ther 2004;310:5966.
  • 78
    Vicentic A, Li Q, Battaglia G, Van de Kar LD. WAY-100635 inhibits 8-OH-DPAT-stimulated oxytocin, ACTH and corticosterone, but not prolactin secretion. Eur J Pharmacol 1998;346:2616.
  • 79
    Bjorkstrand E, Ahlenius S, Smedh U, Uvnas-Moberg K. The oxytocin receptor antagonist 1-deamino-2-D-Tyr-(OEt)-4-Thr-8-Orn-oxytocin inhibits effects of the 5-HT1A receptor agonist 8-OH-DPAT on plasma levels of insulin, cholecystokinin and somatostatin. Regul Pept 1996; 63:4752.
  • 80
    Osei-Owusu P, James A, Crane J, Scrogin KE. 5-Hydroxytryptamine 1A receptors in the paraventricular nucleus of the hypothalamus mediate oxytocin and adrenocorticotropin hormone release and some behavioral components of the serotonin syndrome. J Pharmacol Exp Ther 2005;313:132430.
  • 81
    Van de Kar LD, Levy AD, Li Q, Brownfield MS. A comparison of the oxytocin and vasopressin responses to the 5-HT1A agonist and potential anxiolytic drug alnespirone (S-20499). Pharmacol Biochem Behav 1998;60:67783.
  • 82
    Coolen LM. The neural organization of sexual behavior in the male rat: A functional neuroanatomical Fos-study. PhD Thesis. Nijmegen: The Netherlands; 1995.
  • 83
    Li Q, Muma NA, Battaglia G, Van de Kar LD. A desensitization of hypothalamic 5-HT1A receptors by repeated injections of paroxetine: Reduction in the levels of G (i) and G (o) proteins and neuroendocrine responses, but not in the density of 5-HT1A receptors. J Pharmacol Exp Ther 1997;282:158190.
  • 84
    Serres F, Muma NA, Raap DK, Garcia F, Battaglia G, Van de Kar LD. Coadministration of 5-hydroxytryptamine (1A) antagonist WAY-100635 prevents fluoxetine-induced desensitization of postsynaptic 5-hydroxytryptamine (1A) receptors in hypothalamus. J Pharmacol Exp Ther 2000; 294:296301.
  • 85
    D’Souza DN, Zhang Y, Garcia F, Battaglia G, Van De Kar LD. Destruction of serotonergic nerve terminals prevents fluoxetine-induced desensitization of hypothalamic 5-HT (1A) receptors. Psychopharmacology (Berl) 2002;164:392400.
  • 86
    Raap DK, Garcia F, Muma NA, Wolf WA, Battaglia G, Van De Kar LD. Sustained desensitization of hypothalamic 5-Hydroxytryptamine1A receptors after discontinuation of fluoxetine: Inhibited neuroendocrine responses to 8-hydroxy-2-(Dipropylamino) Tetralin in the absence of changes in Gi/o/z proteins. J Pharmacol Exp Ther 1999; 288:5617.
  • 87
    Raap DK, Evans S, Garcia F, Li Q, Muma NA, Wolf WA, Battaglia G, Van De Kar LD. Daily injections of fluoxetine induce dose-dependent desensitization of hypothalamic 5-HT1A receptors: Reductions in neuroendocrine responses to 8-OH-DPAT and in levels of Gz and Gi proteins. J Pharmacol Exp Ther 1999;288:98106.
  • 88
    Uvnas-Moberg K, Bjokstrand E, Hillegaart V, Ahlenius S. Oxytocin as a possible mediator of SSRI-induced antidepressant effects. Psychopharmacology (Berl) 1999;142:95101.
  • 89
    Uvnas-Moberg K. Oxytocin may mediate the benefits of positive social interaction and emotions. Psychoneuroendocrinology 1998;23:81935.
  • 90
    Neumann ID, Kromer SA, Toschi N, Ebner K. Brain oxytocin inhibits the (re)activity of the hypothalamo-pituitary-adrenal axis in male rats: Involvement of hypothalamic and limbic brain regions. Regul Pept 2000;96:318.
  • 91
    Ring RH, Malberg JE, Potestio L, Ping J, Boikess S, Luo B, Schechter LE, Rizzo S, Rahman Z, Rosenzweig-Lipson S. Anxiolytic-like activity of oxytocin in male mice: Behavioral and autonomic evidence, therapeutic implications. Psychopharmacology (Berl) 2006;185:21825.
  • 92
    Windle RJ, Kershaw YM, Shanks N, Wood SA, Lightman SL, Ingram CD. Oxytocin attenuates stress-induced c-fos mRNA expression in specific forebrain regions associated with modulation of hypothalamo-pituitary-adrenal activity. J Neurosci 2004;24:297482.
  • 93
    Windle RJ, Shanks N, Lightman SL, Ingram CD. Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in rats. Endocrinology 1997;138:282934.
  • 94
    Heinrichs M, Baumgartner T, Kirschbaum C, Ehlert U. Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol Psychiatry 2003;54:138998.
  • 95
    Uvnas-Moberg K, Ahlenius S, Hillegaart V, Alster P. High doses of oxytocin cause sedation and low doses cause an anxiolytic-like effect in male rats. Pharmacol Biochem Behav 1994;49:1016.
  • 96
    Arletti R, Benelli A, Poggioli R, Luppi P, Menozzi B, Bertolini A. Aged rats are still responsive to the antidepressant and memory-improving effects of oxytocin. Neuropeptides 1995;29:17782.
  • 97
    Petersson M, Hulting AL, Uvnas-Moberg K. Oxytocin causes a sustained decrease in plasma levels of corticosterone in rats. Neurosci Lett 1999; 264:414.
  • 98
    De Jong TR, Pattij T, Veening JG, Dederen PJ, Waldinger MD, Cools AR, Olivier B. Effects of chronic paroxetine pretreatment on (+/-)-8-hydroxy-2-(di-n-propyl-amino) tetralin induced c-fos expression following sexual behavior. Neuroscience 2005;134:135161.
  • 99
    Carter CS. Oxytocin and sexual behavior. Neurosci Biobehav Rev 1992;16:13144.
  • 100
    Gimpl G, Fahrenholz F. The oxytocin receptor system: Structure, function, and regulation. Physiol Rev 2001;81:62983.
  • 101
    Insel TR, Young L, Wang Z. Central oxytocin and reproductive behaviours. Rev Reprod 1997;2:2837.
  • 102
    Neumann I, Russell JA, Landgraf R. Oxytocin and vasopressin release within the supraoptic and paraventricular nuclei of pregnant, parturient and lactating rats: A microdialysis study. Neuroscience 1993;53:6575.
  • 103
    Douglas AJ, Leng G, Russell JA. The importance of oxytocin mechanisms in the control of mouse parturition. Reproduction 2002;123:54352.
  • 104
    Benoussaidh A, Maurin Y, Rampin O. Possible neural mediation of the central effects of oxytocin on uterine motility. Am J Physiol Regul Integr Comp Physiol 2005;289:R798804.
  • 105
    Uckert S, Becker AJ, Ness BO, Stief CG, Scheller F, Knapp WH, Jonas U. Oxytocin plasma levels in the systemic and cavernous blood of healthy males during different penile conditions. World J Urol 2003;20:3236.
  • 106
    Kruger TH, Haake P, Chereath D, Knapp W, Janssen OE, Exton MS, Schedlowski M, Hartmann U. Specificity of the neuroendocrine response to orgasm during sexual arousal in men. J Endocrinol 2003;177:5764.
  • 107
    Carmichael MS, Humbert R, Dixen J, Palmisano G, Greenleaf W, Davidson JM. Plasma oxytocin increases in the human sexual response. J Clin Endocrinol Metab 1987;64:2731.
  • 108
    Murphy MR, Seckl JR, Burton S, Checkley SA, Lightman SL. Changes in oxytocin and vasopressin secretion during sexual activity in men. J Clin Endocrinol Metab 1987;65:73841.
  • 109
    Stoneham MD, Everitt BJ, Hansen S, Lightman SL, Todd K. Oxytocin and sexual behaviour in the male rat and rabbit. J Endocrinol 1985;107:97106.
  • 110
    Hughes AM, Everitt BJ, Lightman SL, Todd K. Oxytocin in the central nervous system and sexual behaviour in male rats. Brain Res 1987;414:1337.
  • 111
    Hillegaart V, Alster P, Uvnas-Moberg K, Ahlenius S. Sexual motivation promotes oxytocin secretion in male rats. Peptides 1998;19:3945.
  • 112
    Nishitani S, Moriya T, Kondo Y, Sakuma Y, Shinohara K. Induction of Fos immunoreactivity in oxytocin neurons in the paraventricular nucleus after female odor exposure in male rats: Effects of sexual experience. Cell Mol Neurobiol 2004;24: 28391.
  • 113
    Witt DM, Insel TR. Increased Fos expression in oxytocin neurons following masculine sexual behavior. J Neuroendocrinol 1994;6:138.
  • 114
    Caquineau C, Leng G, Guan XM, Jiang M, Van der Ploeg L, Douglas AJ. Effects of alpha-melanocyte-stimulating hormone on magnocellular oxytocin neurones and their activation at intromission in male rats. J Neuroendocrinol 2006;18:68591.
  • 115
    Pattij T, De Jong TR, Uitterdijk A, Waldinger MD, Veening JG, Cools AR, Van Der Graaf PH, Olivier B. Individual differences in male rat ejaculatory behaviour: Searching for models to study ejaculation disorders. Eur J Neurosci 2005;22:72434.
  • 116
    Yanagimoto M, Honda K, Goto Y, Negoro H. Afferents originating from the dorsal penile nerve excite oxytocin cells in the hypothalamic paraventricular nucleus of the rat. Brain Res 1996;733: 2926.
  • 117
    Honda K, Yanagimoto M, Negoro H, Narita K, Murata T, Higuchi T. Excitation of oxytocin cells in the hypothalamic supraoptic nucleus by electrical stimulation of the dorsal penile nerve and tactile stimulation of the penis in the rat. Brain Res Bull 1999;48:30913.
  • 118
    Liu YC, Salamone JD, Sachs BD. Impaired sexual response after lesions of the paraventricular nucleus of the hypothalamus in male rats. Behav Neurosci 1997;111:13617.
  • 119
    Ackerman AE, Lange GM, Clemens LG. Effects of paraventricular lesions on sex behavior and seminal emission in male rats. Physiol Behav 1997; 63:4953.
  • 120
    Argiolas A, Collu M, Gessa GL, Melis MR, Serra G. The oxytocin antagonist d (CH2) 5Tyr (Me)-Orn8-vasotocin inhibits male copulatory behaviour in rats. Eur J Pharmacol 1988;149:38992.
  • 121
    Argiolas A, Collu M, D’Aquila P, Gessa GL, Melis MR, Serra G. Apomorphine stimulation of male copulatory behavior is prevented by the oxytocin antagonist d (CH2) 5 Tyr (Me)-Orn8-vasotocin in rats. Pharmacol Biochem Behav 1989;33:813.
  • 122
    Arletti R, Calza L, Giardino L, Benelli A, Cavazzuti E, Bertolini A. Sexual impotence is associated with a reduced production of oxytocin and with an increased production of opioid peptides in the paraventricular nucleus of male rats. Neurosci Lett 1997;233:658.
  • 123
    Whittington K, Assinder SJ, Parkinson T, Lapwood KR, Nicholson HD. Function and localization of oxytocin receptors in the reproductive tissue of rams. Reproduction 2001;122:31725.
  • 124
    Filippi S, Vannelli GB, Granchi S, Luconi M, Crescioli C, Mancina R, Natali A, Brocchi S, Vignozzi L, Bencini E, Noci I, Ledda F, Forti G, Maggi M. Identification, localization and functional activity of oxytocin receptors in epididymis. Mol Cell Endocrinol 2002;193:89100.
  • 125
    Byrne MM, Rolf C, Depenbusch M, Cooper TG, Nieschlag E. Lack of effect of a single i.v. dose of oxytocin on sperm output in severely oligozoospermic men. Hum Reprod 2003;18:2098102.
  • 126
    Walch K, Eder R, Schindler A, Feichtinger W. The effect of single-dose oxytocin application on time to ejaculation and seminal parameters in men. J Assist Reprod Genet 2001;18:6559.
  • 127
    Arletti R, Benelli A, Bertolini A. Sexual behavior of aging male rats is stimulated by oxytocin. Eur J Pharmacol 1990;179:37781.
  • 128
    Palmer CW, Amundson SD, Brito LF, Waldner CL, Barth AD. Use of oxytocin and cloprostenol to facilitate semen collection by electroejaculation or transrectal massage in bulls. Anim Reprod Sci 2004;80:21323.
  • 129
    Zhang XH, Filippi S, Vignozzi L, Morelli A, Mancina R, Luconi M, Donati S, Marini M, Vannelli GB, Forti G, Maggi M. Identification, localization and functional in vitro and in vivo activity of oxytocin receptor in the rat penis. J Endocrinol 2005;184:56776.
  • 130
    Vignozzi L, Filippi S, Luconi M, Morelli A, Mancina R, Marini M, Vannelli GB, Granchi S, Orlando C, Gelmini S, Ledda F, Forti G, Maggi M. Oxytocin receptor is expressed in the penis and mediates an estrogen-dependent smooth muscle contractility. Endocrinology 2004;145:182334.
  • 131
    Mens WB, Witter A, Van Wimersma Greidanus TB. Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): Half-times of disappearance of these neuropeptides from CSF. Brain Res 1983;262:1439.
  • 132
    Carro-Juarez M, Rodriguez-Manzo G. Evidence for the presence and functioning of the spinal generator for ejaculation in the neonatal male rat. Int J Impot Res 2005;17:2706.
  • 133
    Argiolas A, Melis MR. The role of oxytocin and the paraventricular nucleus in the sexual behaviour of male mammals. Physiol Behav 2004;83:30917.
  • 134
    Andersson KE. Pharmacology of penile erection. Pharmacol Rev 2001;53:41750.
  • 135
    Melis MR, Argiolas A, Gessa GL. Oxytocin-induced penile erection and yawning: Site of action in the brain. Brain Res 1986;398:25965.
  • 136
    Chen K, Chang LS. Oxytocinergic neurotransmission at the hippocampus in the central neural regulation of penile erection in the rat. Urology 2001;58:10712.
  • 137
    Giuliano F, Bernabe J, McKenna K, Longueville F, Rampin O. Spinal proerectile effect of oxytocin in anesthetized rats. Am J Physiol Regul Integr Comp Physiol 2001;280:R18707.
  • 138
    Marson L, Platt KB, McKenna KE. Central nervous system innervation of the penis as revealed by the transneuronal transport of pseudorabies virus. Neuroscience 1993;55:26380.
  • 139
    Marson L, McKenna KE. CNS cell groups involved in the control of the ischiocavernosus and bulbospongiosus muscles: A transneuronal tracing study using pseudorabies virus. J Comp Neurol 1996;374:16179.
  • 140
    Gerendai I, Toth IE, Kocsis K, Boldogkoi Z, Rusvai M, Halasz B. Identification of CNS neurons involved in the innervation of the epididymis: A viral transneuronal tracing study. Auton Neurosci 2001;92:110.
  • 141
    Orr R, Marson L. Identification of CNS neurons innervating the rat prostate: A transneuronal tracing study using pseudorabies virus. J Auton Nerv Syst 1998;72:415.
  • 142
    Tang Y, Rampin O, Calas A, Facchinetti P, Giuliano F. Oxytocinergic and serotonergic innervation of identified lumbosacral nuclei controlling penile erection in the male rat. Neuroscience 1998;82:24154.
  • 143
    Veronneau-Longueville F, Rampin O, Freund-Mercier MJ, Tang Y, Calas A, Marson L, McKenna KE, Stoeckel ME, Benoit G, Giuliano F. Oxytocinergic innervation of autonomic nuclei controlling penile erection in the rat. Neuroscience 1999;93:143747.
  • 144
    Wagner CK, Clemens LG. Neurophysin-containing pathway from the paraventricular nucleus of the hypothalamus to a sexually dimorphic motor nucleus in lumbar spinal cord. J Comp Neurol 1993;336:10616.
  • 145
    Tang Y, Rampin O, Giuliano F, Ugolini G. Spinal and brain circuits to motoneurons of the bulbospongiosus muscle: Retrograde transneuronal tracing with rabies virus. J Comp Neurol 1999; 414:16792.
  • 146
    Russell JA, Leng G, Douglas AJ. The magnocellular oxytocin system, the fount of maternity: Adaptations in pregnancy. Front Neuroendocrinol 2003;24:2761.
  • 147
    Ivell R, Balvers M, Rust W, Bathgate R, Einspanier A. Oxytocin and male reproductive function. Adv Exp Med Biol 1997;424:25364.
  • 148
    Waldinger MD, Berendsen HH, Blok BF, Olivier B, Holstege G. Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: The involvement of the serotonergic system. Behav Brain Res 1998;92:1118.
  • 149
    Waldinger MD, Rietschel M, Nothen MM, Hengeveld MW, Olivier B. Familial occurrence of primary premature ejaculation. Psychiatr Genet 1998;8:3740.
  • 150
    Waldinger MD. Lifelong premature ejaculation: Definition, serotonergic neurotransmission and drug treatment. World J Urol 2005;23:1028.
  • 151
    Waldinger MD. The neurobiological approach to premature ejaculation. J Urol 2002;168:235967.
  • 152
    Waldinger MD, Quinn P, Dilleen M, Mundayat R, Schweitzer DH, Boolell M. A multinational population survey of intravaginal ejaculation latency time. J Sex Med 2005;2:4927.
  • 153
    Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH. Proposal for a definition of lifelong premature ejaculation based on epidemiological stopwatch data. J Sex Med 2005;2:498507.
  • 154
    Waldinger MD, Schweitzer DH. Changing paradigms from a historical DSM-III and DSM-IV view toward an evidence-based definition of premature ejaculation. Part I—Validity of DSM-IV-TR. J Sex Med 2006;3:68292.
  • 155
    Waldinger MD, Schweitzer DH. Changing paradigms from a historical DSM-III and DSM-IV view toward an evidence-based definition of premature ejaculation. Part II—Proposals for DSM-V and ICD-11. J Sex Med 2006;3:693705.
  • 156
    Shapiro B. Premature Ejaculation: A review of 1130 cases. J Urol 1943;50:3749.
  • 157
    Young LJ, Wang Z. The neurobiology of pair bonding. Nat Neurosci 2004;7:104854.
  • 158
    Keverne EB, Curley JP. Vasopressin, oxytocin and social behaviour. Curr Opin Neurobiol 2004;14:77783.
  • 159
    Marson L, McKenna KE. Serotonergic neurotoxic lesions facilitate male sexual reflexes. Pharmacol Biochem Behav 1994;47:8838.
  • 160
    Marson L, McKenna KE. A role for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes. Exp Brain Res 1992; 88:31320.
  • 161
    De Jong TR, Veening JG, Waldinger MD, Cools AR, Olivier B. Serotonin and the neurobiology of the ejaculatory threshold. Neurosci Biobehav Rev 2006;30:893907.
  • 162
    Wilson JR, Adler N, Le Boeuf B. The effects of intromission frequency on successful pregnancy in the female rat. Proc Natl Acad Sci USA 1965; 53:13925.
  • 163
    Salis PJ, Dewsbury DA. p-Chlorophenylalanine facilitates copulatory behaviour in male rats. Nature 1971;232:4001.
  • 164
    Ahlenius S, Eriksson H, Larsson K, Modigh K, Sodersten P. Mating behavior in the male rat treated with p-chlorophenylalanine methyl ester alone and in combination with pargyline. Psychopharmacologia 1971;20:3838.
  • 165
    Yamanouchi K, Kakeyama M. Effect of medullary raphe lesions on sexual behavior in male rats with or without treatments of p-chlorophenylalanine. Physiol Behav 1992;51:5759.
  • 166
    Marson L. Lesions of the periaqueductal gray block the medial preoptic area-induced activation of the urethrogenital reflex in male rats. Neurosci Lett 2004;367:27882.
  • 167
    Montejo-Gonzalez AL, Llorca G, Izquierdo JA, Ledesma A, Bousono M, Calcedo A, Carrasco JL, Ciudad J, Daniel E, De la Gandara J, Derecho J, Franco M, Gomez MJ, Macias JA, Martin T, Perez V, Sanchez JM, Sanchez S, Vicens E. SSRI-induced sexual dysfunction: Fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. J Sex Marital Ther 1997;23:17694.