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A Rational Combination Pharmacotherapy in Men with Erectile Dysfunction who Initially Failed to Oral Sildenafil Citrate Alone: A Pilot Study
Article first published online: 2 MAY 2007
DOI: 10.1111/j.1743-6109.2007.00507.x
Additional Information
How to Cite
Taneja, R. (2007), A Rational Combination Pharmacotherapy in Men with Erectile Dysfunction who Initially Failed to Oral Sildenafil Citrate Alone: A Pilot Study. The Journal of Sexual Medicine, 4: 1136–1141. doi: 10.1111/j.1743-6109.2007.00507.x
Publication History
- Issue published online: 2 MAY 2007
- Article first published online: 2 MAY 2007
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Keywords:
- Erectile Dysfunction;
- Sildenafil Failure;
- Combination Pharmacotherapy
ABSTRACT
Introduction. Erectile dysfunction (ED) is a complex condition wherein men with minimal organic ED may develop a variable degree of psychogenic component sufficient to reduce the efficacy of medical management. A combination of trazodone with sildenafil has been used to overcome both organic as well as psychogenic components, thus improving the results of medical management.
Aim. To evaluate the efficacy of combination of trazodone with sildenafil citrate in treatment of ED in men with initial failure to sildenafil citrate alone.
Main Outcome Measures. The symptoms of ED were evaluated using the Erectile Dysfunction Intensity Scale (EDIS) before and after the treatment.
Methods. Eighteen men with ED who initially failed to respond to sildenafil citrate alone were enrolled in the study between February 2004 and December 2004. All these men were given a priming dose of trazodone for a 2-week period before giving them sildenafil citrate.
Results. Of the 18 men, 12 responded favorably to the above treatment and continued to enjoy good sexual activity while on trazodone and sildenafil. The score on EDIS improved considerably in 12 (66.7%) men, marginally in two (11.1%) men, and did not improve at all in four (22.2%) men.
Conclusions. Priming the patients with trazodone appears to be a reasonably good alternative in patients who have initial failure to oral sildenafil citrate and have been found to have no organic cause of ED. However, large double-blind studies are required to potentiate this hypothesis. Taneja R. A rational combination pharmacotherapy in men with erectile dysfunction who initially failed to oral sildenafil citrate alone: A pilot study. J Sex Med 2007;4:1136–1141.