ORIGINAL RESEARCH—ENDOCRINOLOGY: Two Years of Testosterone Therapy Associated with Decline in Prostate-Specific Antigen in a Man with Untreated Prostate Cancer
Article first published online: 30 OCT 2008
© 2008 International Society for Sexual Medicine
The Journal of Sexual Medicine
Volume 6, Issue 2, pages 574–577, February 2009
How to Cite
Morgentaler, A. (2009), ORIGINAL RESEARCH—ENDOCRINOLOGY: Two Years of Testosterone Therapy Associated with Decline in Prostate-Specific Antigen in a Man with Untreated Prostate Cancer. Journal of Sexual Medicine, 6: 574–577. doi: 10.1111/j.1743-6109.2008.01066.x
- Issue published online: 27 JAN 2009
- Article first published online: 30 OCT 2008
- Prostate Cancer;
Introduction. Testosterone (T) therapy has long been considered contraindicated in men with prostate cancer (PCa). However, the traditional view regarding the relationship of T to PCa has come under new scrutiny, with recent reports suggesting that PCa growth may not be greatly affected by variations in serum T within the near-physiologic range.
Aim. This report details the clinical and prostate-specific antigen (PSA) response of a man with untreated PCa treated with T therapy for 2 years.
Methods. Measurements of serum PSA, total and free T concentrations were obtained at regular intervals at baseline and following initiation of T therapy.
Main Outcome Measure. Serum PSA during T therapy.
Results. An 84-year-old man was seen for symptoms of hypogonadism, with serum total T within the normal range at 400 ng/dL, but with a reduced free T of 7.4 pg/mL (radioimmunoassay [RIA], reference range 10.0–55.0). PSA was 8.5 ng/mL, and 8.1 ng/mL when repeated. Prostate biopsy revealed Gleason 6 cancer in both lobes. He refused treatment for PCa, but requested T therapy, which was initiated with T gel after informed consent regarding possible cancer progression. Serum T increased to a mean value of 699 ng/dL and free T to 17.1 pg/mL. PSA declined to a nadir of 5.2 ng/mL at 10 months, increased slightly to 6.2 ng/mL at 21 months, and then declined to 3.8 ng/mL at 24 months after addition of dutasteride for voiding symptoms. No clinical PCa progression was noted.
Conclusion. A decline in PSA was noted in a man with untreated PCa who received T therapy for 2 years. This case provides support for the notion that PCa growth may not be adversely affected by changes in serum T beyond the castrate or near-castrate range. Morgentaler A. Two years of testosterone therapy associated with decline in prostate-specific antigen in a man with untreated prostate cancer. J Sex Med 2009;6:574–577.