Association of Glycemic Control with Risk of Erectile Dysfunction in Men with Type 2 Diabetes
Article first published online: 18 MAR 2009
© 2009 International Society for Sexual Medicine
The Journal of Sexual Medicine
Volume 6, Issue 6, pages 1719–1728, June 2009
How to Cite
Lu, C.-C., Jiann, B.-P., Sun, C.-C., Lam, H.-C., Chu, C.-H. and Lee, J.-K. (2009), Association of Glycemic Control with Risk of Erectile Dysfunction in Men with Type 2 Diabetes. Journal of Sexual Medicine, 6: 1719–1728. doi: 10.1111/j.1743-6109.2009.01219.x
- Issue published online: 27 MAY 2009
- Article first published online: 18 MAR 2009
- Glycemic Control;
- Type 2 Diabetes;
- Erectile Dysfunction;
- Glycated Hemoglobin;
- Vascular Risk Factors
Introduction. Improvement in glycemic control is likely to reduce the risk of diabetic complication, while its effect on erectile dysfunction (ED) remains unclear.
Aim. The aim of this study was to evaluate the association of glycemic control with risk of ED in type 2 diabetics.
Methods. A self-administered questionnaire containing Sexual Health Inventory for Men was obtained from 792 subjects with type 2 diabetes at our institution. Clinical data were obtained through chart review.
Main Outcome Measures. The contribution of glycemic control assessed by glycated hemoglobin (HbA1c) level as well as age, duration of diabetes, hypertension (HT), dyslipidemia, and cigarette smoking to risk of ED was evaluated.
Results. Of 792 subjects, 83.6% reported having ED and 43.2% had severe ED. HbA1c level (%) adjusted for age and duration of diabetes was significantly associated with ED (OR 1.12, 95% CI: 1.01–1.25). None of HT, dyslipidemia, and cigarette smoking was a significant risk factor for ED after adjusted for age and duration of diabetes. HbA1c level, age, and duration of diabetes were significant independent risk factors for ED among the younger group (age ≤ 60 years), and only age and duration of diabetes were independent risk factors among the older group (age > 60 years). For the risk of severe ED, compared with no and mild to moderate ED, HbA1c level, duration of diabetes, and HT were independent risk factors among the younger group, and only age was an independent factor among the older group.
Conclusions. Better glycemic control probably would reduce the prevalence of ED and its severity among the younger men with type 2 diabetes. For the older group, aging was the major determinant for ED risk among this population with type 2 diabetes. Lu C-C, Jiann B-P, Sun C-C, Lam H-C, Chu C-H, Lee J-K. Association of glycemic control with risk of erectile dysfunction in men with type 2 diabetes. J Sex Med 2009;6:1719–1728.