ORIGINAL RESEARCH—EPIDEMIOLOGY: The Incidence of Invasive Breast Cancer Among Women Prescribed Testosterone for Low Libido
Article first published online: 24 APR 2009
© 2009 International Society for Sexual Medicine
The Journal of Sexual Medicine
Volume 6, Issue 7, pages 1850–1856, July 2009
How to Cite
Davis, S. R., Wolfe, R., Farrugia, H., Ferdinand, A. and Bell, R. J. (2009), ORIGINAL RESEARCH—EPIDEMIOLOGY: The Incidence of Invasive Breast Cancer Among Women Prescribed Testosterone for Low Libido. Journal of Sexual Medicine, 6: 1850–1856. doi: 10.1111/j.1743-6109.2009.01289.x
- Issue published online: 24 JUN 2009
- Article first published online: 24 APR 2009
- Breast Cancer;
- Sexual Function;
Introduction. Although the efficacy of testosterone for the treatment of hypoactive sexual desire disorder is well established, the effect of testosterone therapy on breast cancer risk remains uncertain.
Aim. The incidence of invasive breast cancer among past and current testosterone users.
Methods. Retrospective cohort study of 631 women ever treated with testosterone between January 1989 and December 2007 in a clinical endocrinology practice.
Main Outcome Measure. The incidence of invasive breast cancer since first exposure, and the standardized incidence rate ratio (IRR) calculated using Australian age-specific incidence rates for 2005.
Results. The mean age of the women at first exposure to testosterone therapy was 49.1 ± 8.2 years, median treatment duration, 1.3 years, and mean follow-up of 6.7 ± 4.6 years, providing 4,015 woman-years of follow-up. Twelve cases of invasive breast cancer occurred among 599 women breast cancer-free before treatment, giving an age adjusted IRR of 1.35 (95% confidence interval 0.76–2.38). There was no evidence of an independent effect of duration of exposure on breast cancer risk.
Conclusion. In this study, testosterone use was not associated with a significant increase in breast cancer risk. Davis SR, Wolfe R, Farrugia H, Ferdinand A, and Bell RJ. The incidence of invasive breast cancer among women prescribed testosterone for low libido. J Sex Med 2009;6:1850–1856.