ORIGINAL RESEARCH—ERECTILE DYSFUNCTION: The Associations Among eNOS G894T Gene Polymorphism, Erectile Dysfunction, and Benign Prostate Hyperplasia-Related Lower Urinary Tract Symptoms

Authors

  • Yung-Chin Lee MD,

    1. Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;
    2. Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
    3. Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
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  • Wen-Jeng Wu MD, PhD,

    1. Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;
    2. Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
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  • Chia-Chu Liu MD,

    1. Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;
    2. Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
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  • Chii-Jye Wang MD, PhD,

    1. Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;
    2. Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
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  • Wei-Ming Li MD,

    1. Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;
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  • Chun-Hsiung Huang MD, PhD,

    1. Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;
    2. Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
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  • Hsin-Chih Yeh MD,

    1. Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;
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  • Hung-Lung Ke MD,

    1. Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;
    2. Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
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  • Shu-Pin Huang MD, PhD

    Corresponding author
    1. Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;
    2. Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
    3. Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan
      Shu-Pin Huang, MD, PhD, Department of Urology, Kaohsiung Medical University Hospital No. 100, Tzyou 1st Rd., Kaohsiung 807, Taiwan. Tel: 886 7 3211033; Fax: 886 7 3211033; E-mail: shpihu@yahoo.com.tw
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Shu-Pin Huang, MD, PhD, Department of Urology, Kaohsiung Medical University Hospital No. 100, Tzyou 1st Rd., Kaohsiung 807, Taiwan. Tel: 886 7 3211033; Fax: 886 7 3211033; E-mail: shpihu@yahoo.com.tw

ABSTRACT

Introduction.  A number of literature has now identified the role of impaired nitric oxide synthase/nitric oxide pathway in the endothelium as the central to the development of erectile dysfunction (ED) and benign prostate hyperplasia-related lower urinary tract symptoms (BPH/LUTS). Recently a few studies have reported the associations between endothelial nitric oxide synthase (eNOS) G894T gene polymorphisms and ED. However, there has been no report investigating the eNOS G894T genetic susceptibility factor for both ED and BPH/LUTS.

Aim.  To investigate the possible associations among eNOS G894T polymorphism, ED, and BPH/LUTS in a Taiwanese population.

Main Outcome Measures.  Patients with ED were defined as those having a 5-item International Index of Erectile Function-5 <21.

Methods.  In all, 372 Taiwanese men underwent a free health screening were enrolled. All the men had complete clinical data and questionnaires taken. The eNOS G894T polymorphisms were determined using the polymerase chain reaction-restriction fragment length polymorphism method.

Results.  Three hundred seventy-two men had a mean (standard deviation) age of 60.2 (8.8) years. With multivariate analysis, our data identified that aging, diabetes mellitus (DM), and eNOS G894T gene polymorphism were three independent common risk factors for both ED and BPH/LUTS (P < 0.001, = 0.036, and P = 0.039 for ED; P = 0.034, P = 0.004, and P = 0.016 for BPH/LUTS, respectively). The eNOS 894T allele carriers had significantly higher prevalence of ED (77.9% vs. 60.4%, P = 0.012) and higher International Prostate Symptom score (IPSS) (13.3 ± 10.7 vs. 9.3 ± 7.8, = 0.001) than G allele carriers.

Conclusions.  Our results showed that aging, DM, and eNOS 894T allele carrier gene polymorphism were the three independently common risk factors for both ED and BPH/LUTS in the Taiwanese population. The eNOS 894T allele carriers had significantly higher frequencies of ED and higher IPSS, suggesting that eNOS G894T gene polymorphisms may play an implication as a genetic susceptibility factor for both ED and BPH/LUTS. Lee YC, Wu WJ, Liu CC, Wang CJ, Li WM, Huang CH, Yeh HC, Ke HL, and Huang SP. The associations among eNOS G894T gene polymorphism, erectile dysfunction, and benign prostate hyperplasia-related lower urinary tract symptoms. J Sex Med 2009;6:3158–3165.

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