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A Cross-Sectional Study for the Analysis of Clinical, Sexual and Laboratory Conditions Associated to Peyronie's Disease

Authors

  • Ernani Luis Rhoden MD, PhD,

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    1. Universidade Federal do Rio Grande do Sul (UFRGS)—Postgraduate Course in Medical Sciences, Porto Alegre, RS, Brazil;
    2. Fundação Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)—Disciplina de Urologia, Porto Alegre, Brazil;
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  • Charles Edison Riedner MD,

    1. Hospital Militar de Porto Alegre—Serviço de Urologia, Porto Alegre, Brazil
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  • Sandra Fuchs MD, PhD,

    1. Universidade Federal do Rio Grande do Sul (UFRGS)—Postgraduate Course in Medical Sciences, Porto Alegre, RS, Brazil;
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  • Eduardo Porto Ribeiro MD,

    1. Universidade Federal do Rio Grande do Sul (UFRGS)—Postgraduate Course in Medical Sciences, Porto Alegre, RS, Brazil;
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  • Graziele Halmenschlager MS

    1. Fundação Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)—Disciplina de Urologia, Porto Alegre, Brazil;
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Errata

This article is corrected by:

  1. Errata: ERRATA Volume 7, Issue 6, 2296, Article first published online: 1 June 2010

Ernani Luis Rhoden, MD, PhD, Rua Jaragua 370/302, Porto Alegre, RS, 90450-140, Brazil. Tel: 55 51 33333144; Fax: 55 51 33333144; E-mail: ernanirhoden@yahoo.com.br

ABSTRACT

Introduction.  Although Peyronie's Disease (PD) was first described over 250 years ago, its precise etiology remains obscure.

Aim.  Analyze a variety of potential associated factors with PD, including erectile dysfunction.

Materials and Methods.  This cross-sectional study included 83 consecutive men with PD and 252 age-matched controls. All men completed the International Index of Erectile Function (IIEF) and were evaluated regarding their clinical and demographic characteristics, comorbidities, and used medications. Anthropometric measures included body mass index and waist circumference (WC). Fasting blood glucose, lipid profile, total testosterone, and dehydroepiandrosterone-sulfate were determined.

Main Outcome Measures.  Clinical and laboratory characteristics associated to PD.

Results.  The mean age was 59.2 ± 10 years in the cases and 59.7 ± 12 years in the controls. Marital status, current smoking, and excessive consumption of alcoholic beverages were similar between groups (P > 0.05). PD was more common among white skin color males (P = 0.001). The mean score for each IIEF domain and the androgen levels were similar in the two groups. Thiazides were the only medication associated to PD (P = 0.03). Dupuytren's disease was more frequent among individuals with PD (P = 0.001). The distribution of all other comorbidities investigated was similar between groups (P > 0.05). The characteristics WC > 102 cm and levels of low-density lipoprotein (LDL) > 130 mg/dL were more prevalent in the controls (P < 0.05). After multivariate analysis, white skin color (OR: 8.47, 95%CI: 1.98–36.24) and thiazide use (OR: 2.29, 95%CI: 1.07–4.90) were associated to PD, and LDL > 130 mg/dL (OR: 0.55, 95%CI: 0.32–0.92) and WC > 102 cm (OR: 0.53, 95%CI: 0.29–0.96) were inversely associated to PD.

Conclusions.  In this study, PD was more common among white skin colored males. An inverse relationship with the presence of elevated serum levels of LDL and WC was observed. We found no association with medications other than thiazides and comorbidities other than Dupuytren's disease. Androgen serum levels and sexual dysfunction had also no association to PD. Rhoden EL, Riedner CE, Fuchs S, Ribeiro EP, and Halmenschlager G. A cross-sectional study for the analysis of clinical, sexual and laboratory conditions associated to Peyronie's disease. J Sex Med 2010;7:1529–1537.

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