• Schizophrenia;
  • Antipsychotics;
  • Sexual Dysfunction;
  • Psychosis;
  • Medication-Associated Sexual Dysfunction;
  • Iatrogenic Sexual Dysfunction


Introduction.  Although it is a troublesome side effect, information on antipsychotic-induced sexual dysfunction is limited.

Aim.  To evaluate the frequency of sexual dysfunction and its impact on treatment adherence in patients with a psychotic disorder treated with various antipsychotics under routine clinical conditions.

Methods.  Subjects included were sexually active male and female patients 18 years of age or older with a diagnosis of schizophrenia, schizophreniform disorder, schizoaffective disorder, or other psychotic disorder. This was a multicenter, cross-sectional, and naturalistic study conducted by 18 investigators. In addition to sexual functioning, we recorded demographic data, psychiatric diagnosis according to the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition), and medication history.

Main Outcome Measure.  Pyschotropic-Related Sexual Dysfunction Questionnaire (PRSexDQ-SalSex).

Results.  All the analyses were performed in the 243 evaluable patients. Most patients were males (71%), and the most common diagnosis was schizophrenia (71%). Overall, 46% of the patients exhibited sexual dysfunction according to the assessment with the SalSex (50% of the males and 37% of the females). Only 37% of the patients with sexual dysfuntion spontaneously reported it. Among the patients exhibiting sexual dysfunction, 32% reported to have poor tolerance to the disturbance. With the exception of conventionals depot, which had a very important and greater effect on females’ sexual funtioning, the severity and tolerance of sexual dysfunction were worse in males than in females regardless of the antipsychotic studied. In the univariate logistic regression analysis, using olanzapine as a reference category, risperidone (odds ratio [OR] 7.45, 95% confidence interval [CI] 3.73–14.89) and conventionals, depot (OR 4.57, 95% CI 1.72–12.13) and nondepot (OR 4.92, 95% CI 1.43–16.93), showed a significant increased risk of sexual dysfunction.

Conclusions.  Our results show that sexual dysfunction is very common in patients receiving long-term treatment with antipsychotics, and it is associated with a great impact in a substantial proportion of patients. Montejo AL, Majadas S, Rico-Villademoros F, LLorca G, de la Gándara J, Franco M, Martín-Carrasco M, Aguera L, and Prieto N. Frequency of sexual dysfunction in patients with a psychotic disorder receiving antipsychotics. J Sex Med 2010;7:3404–3413.