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The Dose-Dependent Effect of Chronic Administration of Haloperidol, Risperidone, and Quetiapine on Sexual Behavior in the Male Rat

Authors

  • Xiang Rong Zhang PhD,

    1. Neuropsychiatric Research Institute, School of Clinical Medicine, Southeast University, Nanjing, China;
    2. Department of Neuropsychiatry, Affiliated ZhongDa Hospital of Southeast University, Nanjing, China;
    3. Department of Psychiatry, School of Medicine and Dentistry, Queen's University Belfast, UK;
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  • Zhi Jun Zhang PhD, MD,

    Corresponding author
    1. Neuropsychiatric Research Institute, School of Clinical Medicine, Southeast University, Nanjing, China;
    2. Department of Neuropsychiatry, Affiliated ZhongDa Hospital of Southeast University, Nanjing, China;
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  • Trisha A. Jenkins PhD,

    1. Department of Psychiatry, School of Medicine and Dentistry, Queen's University Belfast, UK;
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  • Wei Rong Cheng MSc,

    1. Department of Psychiatry, Nanjing Brain Hospital, Nanjing, China
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  • Gavin P. Reynolds PhD

    Corresponding author
    1. Department of Psychiatry, School of Medicine and Dentistry, Queen's University Belfast, UK;
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Zhi Jun Zhang, Professor, The Department of Neuropsychiatry, Affiliated ZhongDa Hospital of Southeast University, No. 87 DingJiaQiao, Nanjing, Jiang Su 210009, China. Tel: 0086-25-8372023; Fax: 0086-25-83272090; E-mail: zhijunzhang838@yahoo.com.cn;

Gavin P. Reynolds, Professor, Department of Psychiatry, School of Medicine and Dentistry, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK. Tel: 0044-28-9097 2631; Fax: 0044-28-9097 5870; E-mail: g.reynolds@qub.ac.uk

ABSTRACT

Introduction.  Antipsychotic drug-induced sexual dysfunction is a common and problematic side effect, which may diminish quality of life and lead to treatment noncompliance. Up to date, there is still a scarcity of basic research regarding the chronic effects of most antipsychotic agents on sexual behavior.

Aim.  The present study investigated the effect of a range of doses of three antipsychotic drugs (haloperidol, risperidone, and quetiapine) on male rat sexual competence following chronic administration.

Methods.  Twelve groups of Sprague-Dawley rats (n = 7 each) received by gavage haloperidol (0.25, 0.5, or 1 mg/kg), risperidone (0.125, 0.25, or 0.5 mg/kg), quetiapine (10, 20, and 40 mg/kg) or vehicle (distilled water) in the corresponding control groups, respectively, once daily for 21 days. Sexual function was evaluated by the copulatory behavior test 10 hours after the last dose.

Main Outcome Measure.  The male rat behavioral parameters of copulatory test.

Results.  Sexual function was widely and significantly suppressed by high dose haloperidol (1 mg/kg) after 21 days administration compared with the control group, which included both frequency and latency of intromission and ejaculation. Only ejaculation latency was significantly impaired after administration with 0.5 mg/kg haloperidol. Compared with the control group, high dose risperidone (0.5 mg/kg) significantly decreased the frequency of mounting. There were no significant changes in sexual behavior with the lower doses of either haloperidol or risperidone. Sexual behavior was not influenced by any dose of quetiapine.

Conclusions.  Haloperidol and risperidone, but not quetiapine, could impair sexual competence in a dose-related manner in male rats. Zhang XR, Zhang ZJ, Jenkins TA, Cheng WR, and Reynolds GP. The dose-dependent effect of chronic administration of haloperidol, risperidone, and quetiapine on sexual behavior in the male rat. J Sex Med **;**:**–**.

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