• Urethral Cancer;
  • Penile Cancer;
  • Genital Piercing;
  • Neoplasms;
  • Squamous Cell


Introduction.  Medical practitioners should be aware of genital piercing and its potential complications. General piercings are associate with complications common to all piercings as well as some unique to urethral piercings. Specifically, the association between carcinoma and genital piercing is not well recognized.

Aim.  The present study is a report of two cases describing squamous cell carcinoma associated with genital piercing.

Methods.  Case reports of two men admitted to an academic medical center.

Results.  A 60-year-old man with a history of HIV and hepatitis C as well as a Prince Albert piercing presented for treatment of a urethrocutaneous fistula. A biopsy of indurated granulation tissue surrounding the fistula revealed invasive, moderately-differentiated squamous cell carcinoma. A 56-year-old man with a history of HIV, hepatitis C, and a Prince Albert piercing presented following a single episode of gross hematuria. He also reported splitting of his urinary stream. On physical examination, areas of necrosis were noted on the glans penis; biopsy revealed invasive, poorly-differentiated squamous cell carcinoma.

Conclusions.  The present study is the first to suggest a possible association between squamous cell carcinoma of the penis/urethra and genital piercing. Patients with genital piercings, especially those with concurrent risk factors such as HIV and HCV, should be counselled about this rare complication. Edlin RS, Aaronson DS, Wu AK, Blaschko SD, Yang G, Erickson BA, and McAninch JW. Squamous cell carcinoma at the site of a Prince Albert's piercing. J Sex Med 2010;7:2280–2283.