The Potential Impact of Metabolic Syndrome on Erectile Dysfunction in Aging Taiwanese Males

Authors

  • Yung-Chin Lee MD,

    1. Department of Urology, Kaohsiung Medical University Hospital, Department of urology, Faculty of medicine, College of medicine, Kaohsiung Medical University, Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
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  • Chia-Chu Liu MD,

    1. Department of Urology, Kaohsiung Medical University Hospital, Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
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  • Chun-Nung Huang MD, PhD,

    1. Department of Urology, Kaohsiung Medical University Hospital, Department of urology, Faculty of medicine, College of medicine, Kaohsiung Medical University;
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  • Wei-Ming Li MD,

    1. Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;
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  • Wen-Jeng Wu MD, PhD,

    1. Department of Urology, Kaohsiung Medical University Hospital, Department of urology, Faculty of medicine, College of medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
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  • Hsin-Chih Yeh MD,

    1. Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;
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  • Chii-Jye Wang MD, PhD,

    1. Department of Urology, Kaohsiung Medical University Hospital, Department of urology, Faculty of medicine, College of medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
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  • Chun-Hsiung Huang MD, PhD,

    1. Department of Urology, Kaohsiung Medical University Hospital, Department of urology, Faculty of medicine, College of medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
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  • Shu-Pin Huang MD, PhD

    Corresponding author
    1. Department of Urology, Kaohsiung Medical University Hospital, Department of urology, Faculty of medicine, College of medicine, Kaohsiung Medical University, Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan
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Shu-Pin Huang, MD, PhD, Department of Urology, Kaohsiung Medical University Hospital No. 100, Tzyou 1st Rd., Kaohsiung 807, Taiwan. Tel: 886-7-3211033; Fax: 886-7-3211033; E-mail: shpihu@yahoo.com.tw

ABSTRACT

Introduction.  Recently, metabolic syndrome (MtS) has received increasing attention. However, investigations regarding the potential impact of MtS and its components on erectile dysfunction (ED) have not been completely clarified.

Aim.  To determine the potential impact of MtS on ED in aging Taiwanese males.

Main Outcome Measure.  The definition of MtS was according to the modified criteria developed by the Bureau of Health Promotion in Taiwan. The presence and severity of ED were evaluated by International Index of Erectile Function 5 (IIEF-5) scores.

Methods.  A total of 639 subjects with a mean age of 60.2 years (range 40–83) were enrolled during a free health screening. All the men had complete clinical data and questionnaires taken. Clinical variables were compared according to MtS and ED prevalence. Multiple logistic regression analysis was used to determine the independent predictors of ED and MtS.

Results.  Using age-adjusted multivariate logistic regression analysis, our results showed that subjects with ED had significantly higher prevalence of MtS (P < 0.01, OR = 2.30, 95% CI: 1.44–3.69). The presence of MtS had significant correlation with lower IIEF-5 scores (P < 0.01), which were associated with the increment of MtS components number (P < 0.01). Among the MtS components, abnormal fasting blood glucose (FBG) was the most significantly independent factor of MtS for ED (P = 0.01, OR = 1.60, 95% CI: 1.09–2.35). Testosterone levels were significantly lower in subjects with MtS (P = 0.05), while inversely correlated with number of MtS components (P < 0.01).

Conclusions.  In aging Taiwanese males, the presence of MtS is strongly associated with ED and abnormal FBG is the most independent predictor for ED. Low testosterone level might be viewed as another possible common denominator for various pathologies linking MtS to ED. Lee Y-C, Liu C-C, Huang C-N, Li W-M, Wu W-J, Yeh H-C, Wang C-J, Huang C-H, and Huang S-P. The potential impact of metabolic syndrome on erectile dysfunction in aging taiwanese males. J Sex Med 2010;7:3127–3134.

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