Central Neuropathic Pain: An Unusual Case of Painful Ejaculation Responding to Topiramate


Rocco Calabrò, MD, PhD, Neurorehabilitation Unit, IRCCS Centro Neurolesi, SS 113 via Palermo, Cda Casazza, Messina 98124, Italy. E-mail: roccos.calabro@centroneurolesi.it, salbro77@tiscali.it


Introduction.  Painful ejaculation (PE) is an uncommon condition and it is usually associated with prostatitis, chronic pelvic pain syndrome, benign prostatic hyperplasia, ejaculatory duct obstruction, radical prostatectomy, and prostate radiation. Topiramate (TPM) is a new antiepileptic drug with recognized efficacy in neuropathic pain.

Aim.  The study is aimed to evaluate TPM efficacy in ejaculation pain.

Methods.  Following a spinal cord injury, a 53-year-old man was referred to our institute for persistent PE. Neurological examination showed mild hypoesthesia of the genital area. Urogenital examination, neurophysiological tools, and computed tomography of the dorso-lumbar spine were normal.

Main Outcome Measures.  The main outcome measure was the visual analogue scale.

Results.  Since pain was refractory to conventional neuropathic pharmacological therapies, TPM was introduced up to 150 mg daily with a dramatic improvement of PE.

Conclusions.  TPM may be considered as a valid therapeutic option for the treatment of PE. Calabrò RS, Marra A, Quattrini F, Gervasi G, Levita A, and Bramanti P. Central neuropathic pain: An unusual case of painful ejaculation responding to topiramate. J Sex Med 2012;9:3274–3278.