Central Neuropathic Pain: An Unusual Case of Painful Ejaculation Responding to Topiramate
Article first published online: 26 MAY 2010
© 2010 International Society for Sexual Medicine
The Journal of Sexual Medicine
Volume 9, Issue 12, pages 3274–3278, December 2012
How to Cite
Calabrò, R. S., Marra, A., Quattrini, F., Gervasi, G., Levita, A. and Bramanti, P. (2012), Central Neuropathic Pain: An Unusual Case of Painful Ejaculation Responding to Topiramate. Journal of Sexual Medicine, 9: 3274–3278. doi: 10.1111/j.1743-6109.2010.01855.x
- Issue published online: 3 DEC 2012
- Article first published online: 26 MAY 2010
- Central Neuropathic Pain;
- Painful Ejaculation;
- Central Pattern Generator;
- Chronic Prostatitis-chronic Pelvic Pain Syndrome
Introduction. Painful ejaculation (PE) is an uncommon condition and it is usually associated with prostatitis, chronic pelvic pain syndrome, benign prostatic hyperplasia, ejaculatory duct obstruction, radical prostatectomy, and prostate radiation. Topiramate (TPM) is a new antiepileptic drug with recognized efficacy in neuropathic pain.
Aim. The study is aimed to evaluate TPM efficacy in ejaculation pain.
Methods. Following a spinal cord injury, a 53-year-old man was referred to our institute for persistent PE. Neurological examination showed mild hypoesthesia of the genital area. Urogenital examination, neurophysiological tools, and computed tomography of the dorso-lumbar spine were normal.
Main Outcome Measures. The main outcome measure was the visual analogue scale.
Results. Since pain was refractory to conventional neuropathic pharmacological therapies, TPM was introduced up to 150 mg daily with a dramatic improvement of PE.
Conclusions. TPM may be considered as a valid therapeutic option for the treatment of PE. Calabrò RS, Marra A, Quattrini F, Gervasi G, Levita A, and Bramanti P. Central neuropathic pain: An unusual case of painful ejaculation responding to topiramate. J Sex Med 2012;9:3274–3278.