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A New Female Rat Animal Model for Hypoactive Sexual Desire Disorder; Behavioral and Pharmacological Evidence

Authors

  • Eelke M.S. Snoeren MSc,

    Corresponding author
    1. Department of Psychopharmacology, Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
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  • Johnny S.W. Chan BSc,

    1. Department of Psychopharmacology, Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
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  • Trynke R. de Jong PhD,

    1. Department of Psychopharmacology, Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
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  • Marcel D. Waldinger MD, PhD,

    1. Department of Psychopharmacology, Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
    2. Department of Psychiatry and Neurosexuology, Haga Hospital Leyenburg, The Hague, the Netherlands
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  • Berend Olivier PhD,

    1. Department of Psychopharmacology, Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
    2. Yale University School of Medicine, New Haven, CT, USA
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  • Ronald S. Oosting PhD

    1. Department of Psychopharmacology, Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
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Eelke M.S. Snoeren, MSc, Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, Utrecht 3584CA, Netherlands. Tel: +31302531599; Fax: +31302537900; E-mail: e.m.s.snoeren@uu.nl

ABSTRACT

Introduction.  Female sexual dysfunction (FSD) affects 33–48% of women. Female rats with low sexual activity might model FSD.

Aim.  In this study, we have investigated whether in a population of normal female rats, subpopulations of rats exist with different levels of sexual behavior.

Methods.  Sexually experienced, intact, estradiol-primed female rats were placed in an empty compartment adjacent to a compartment with a male. The females were allowed, during 30 minutes, to switch between the compartments via a hole through which only the females could pass (paced mating). Next, we investigated the acute effects on female sexual behavior of apomorphine, a D1- and D2-type dopamine receptor agonist, (+/–)-8-hydroxy-2-(dipropylamino)tetralin hydrobromide (±8-OH-DPAT), a 5-HT1A receptor agonist, and paroxetine, a selective serotonin reuptake inhibitor.

Main Outcome Measures.  Time spent in compartments, proceptive behaviors, contact–return latencies, and percentages of exits were quantified.

Results.  Based on their behavior in the paced mating sex test, estradiol-primed, intact female rats can be divided into three groups: those that mostly avoid the male, a large middle group, and those that mostly approach the male. The avoiders also showed significantly less proceptive behavior than the male approachers. The sexual behavior of the females was relatively stable over time, suggesting the existence of different endophenotypes in female rats. Apomorphine and ±8-OH-DPAT had an inhibiting effect on sexual behavior, but only females dosed with apomorphine showed a different response in avoiders and approachers, more inhibiting effect in avoiders than approachers. Paroxetine had no effect on proceptive behavior.

Discussion.  The stable, male-avoiding behavior of some females might correspond to the characteristics of women with FSD. Therefore, these avoiders are a promising new model for FSD, specifically for sexual desire and/or arousal disorders. Furthermore, the apomorphine data suggest that differences in the dopamine system may (partly) underlie the differences in sexual behaviors between avoiders and approachers. Snoeren EMS, Chan JSW, de Jong TR, Waldinger MD, Olivier B, and Oosting RS. A new female rat animal model for hypoactive sexual desire Disorder; behavioral and pharmacological evidence. J Sex Med 2011;8:44–56.

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