Introduction. The Sexual Interest and Desire Inventory-Female (SIDI-F) is a 13-item scale developed as a clinician-administered assessment tool to measure hypoactive sexual desire disorder (HSDD) severity in women.
Aim. To estimate the reliability and validity of the SIDI-F as a measure of HSDD severity.
Methods. Women, aged 18–65 years, with primary HSDD, Female Sexual Arousal Disorder (FSAD), or no Female Sexual Dysfunction (no FSD) participated in two nontreatment studies (in North America and Europe). On days 0 and 28, subjects were assessed using the SIDI-F, Female Sexual Function Index (FSFI), Changes in Sexual Functioning Questionnaire-Female (CSFQ-F), Locke–Wallace Marital Adjustment Test (MAT) and the Female Sexual Distress Scale (FSDS).
Main Outcome Measures. Discriminant validity, convergent validity, divergent validity, test–retest validity, and internal consistency of the SIDI-F.
Results. The North American study enrolled women with HSDD (N = 113), FSAD (N = 49) and no FSD (N = 61); the European study enrolled women with HSDD (N = 130) and no FSD (N = 124). In both studies, mean SIDI-F total score for women with HSDD was lower than for those with no FSD (P < 0.001, for all) demonstrating discriminant validity. Further, mean SIDI-F total score for women with HSDD was lower than for those with FSAD in the North American study (P < 0.001). Convergent validity with the FSFI and CSFQ-F and divergent validity with MAT were demonstrated. Test–retest reliability and internal consistency were high.
Conclusions. The SIDI-F is a valid and reliable measure of HSDD severity in women. Clayton AH, Goldmeier D, Nappi RE, Wunderlich G, Lewis-D'Agostino DJ, and Pyke R. Validation of the Sexual Interest and Desire Inventory-Female in hypoactive sexual desire disorder. J Sex Med 2010;7:3918–3928.