Karyotyping, Is It Worthwhile in Transsexualism?
Article first published online: 29 NOV 2010
© 2010 International Society for Sexual Medicine
The Journal of Sexual Medicine
Volume 8, Issue 2, pages 475–478, February 2011
How to Cite
Inoubli, A., De Cuypere, G., Rubens, R., Heylens, G., Elaut, E., Van Caenegem, E., Menten, B. and T'Sjoen, G. (2011), Karyotyping, Is It Worthwhile in Transsexualism?. Journal of Sexual Medicine, 8: 475–478. doi: 10.1111/j.1743-6109.2010.02130.x
- Issue published online: 1 FEB 2011
- Article first published online: 29 NOV 2010
- Chromosomal Abnormalities;
- Klinefelter Syndrome;
- Disorders of Sexual Differentiation
Introduction. Karyotyping is often performed in transsexual individuals.
Aim. Quantification and characterization of karyotype findings and abnormalities in transsexual persons.
Main Outcome Measures. Karyotypes were listed both in male-to-female and in female-to-male transsexual persons.
Methods. The data were collected through a retrospective study.
Results. Karyotypes of 368 transsexual individuals (251 male-to-female, 117 female-to-male) are described. Normal findings were found in 97.55%. Prevalence of abnormal karyotypes was 3.19% among male-to-female, and 0.85% among female-to-male transsexuals. Nine karyotypes showed variations; Klinefelter syndrome was confirmed in three persons, whereas others displayed autosomal aberrations.
Conclusion. Karyotyping is only of very limited information in the transsexual population. Inoubli A, De Cuypere G, Rubens R, Heylens G, Elaut E, Van Caenegem E, Menten B, and T'Sjoen G. Karyotyping, is it worthwhile in transsexualism? J Sex Med 2011;8:475–478.