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Asthma and Risk of Erectile Dysfunction—A Nationwide Population-Based Study

Authors

  • Kun-Ta Chou MD,

    1. Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
    2. Department of Chest, Taipei Veterans General Hospital, Taipei, Taiwan
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  • Chin-Chou Huang MD,

    1. Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan
    2. Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    3. Cardiovascular Research Center, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    4. Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    5. Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan
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  • Yuh-Min Chen MD, PhD,

    1. Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    2. Department of Chest, Taipei Veterans General Hospital, Taipei, Taiwan
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  • Diang-Wang Perng MD, PhD,

    1. Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    2. Department of Chest, Taipei Veterans General Hospital, Taipei, Taiwan
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  • Heng-Sheng Chao MD,

    1. Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    2. Department of Chest, Taipei Veterans General Hospital, Taipei, Taiwan
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  • Wan-Leong Chan MD,

    1. Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
    2. Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    3. Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    4. Healthcare and Management Center, Taipei Veterans General Hospital, Taipei, Taiwan
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  • Hsin-Bang Leu MD

    Corresponding author
    1. Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
    2. Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    3. Cardiovascular Research Center, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    4. Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    5. Healthcare and Management Center, Taipei Veterans General Hospital, Taipei, Taiwan
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  • IRB: The Institutional Review Board of Taipei Veterans General Hospital approved the study (VGHIRB no. 201009012IC).

Hsin-Bang Leu, MD, Healthcare and Management Center, Taipei Veterans General Hospital, no. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan. Tel: +886-2-2871-2121 ext. 3424; Fax: +886-2-2875-7735; E-mail: hbleu@vghtpe.gov.tw

ABSTRACT

Introduction.  The increased prevalence of erectile dysfunction (ED) has been reported in patients with chronic obstructive pulmonary disease, and sustained systemic inflammation seems to play a central role in this linkage. Asthma is also a chronic inflammatory airway disorder, eliciting a low-grade systemic inflammation; however, the influence of asthma on ED has not been investigated.

Aim.  Our study strived to explore the relationship of asthma and the subsequent development of ED using a nationwide, population-based database.

Methods.  From 2000 to 2007, we identified newly diagnosed asthma cases involving male patients 18–55 years old. A control cohort without asthma, which was matched for age and comorbidities, was selected for comparison.

Main Outcome Measures.  The two cohorts were followed up, and we observed the occurrence of ED by registry of ED diagnosis in the database.

Results.  Of the 17,302 sampled patients (3,466 asthma patients vs. 13,836 control), 114 (0.66%) experienced ED during a mean follow-up period of 4.56 years, including 34 (0.98% of the asthma patients) from the asthma cohort and 80 (0.58%) from the control group. Subjects with asthma experienced a 1.909-fold (95% confidence interval [CI], 1.276–2.856; P = 0.002) increase in incident ED, which was independent of age, the number of clinical visits for urologist, and other comorbidities. Kaplan–Meier analysis also revealed the tendency of asthma patients for ED development (log rank test, P = 0.002). The risk of ED was higher in cases with more frequent clinical visits for asthma (asthma patients with clinical visits with >24 times/year vs. <12 times/year: hazard ratio [HR]: 4.154 [95% CI:1.392–12.396], P = 0.011; clinical visits with 12–24 times/year vs. <12 times/year HR: 3.534 [95% CI:1.245–10.032], P = 0.018).

Conclusions.  Asthma may be an independent risk factor for ED, and risk of ED probably increases in accordance with asthma severity. Chou K-T, Huang C-C, Chen Y-M, Perng D-W, Chao H-S, Chan W-L, and Leu H-B. Asthma and risk of erectile dysfunction—A nationwide population-based study. J Sex Med 2011;8:1754–1760.

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