Carcinosarcoma of the fallopian tube: Report of four cases and review of literature
Version of Record online: 12 MAR 2012
© 2012 Wiley Publishing Asia Pty Ltd
Asia-Pacific Journal of Clinical Oncology
Volume 8, Issue 3, pages 303–311, September 2012
How to Cite
YOKOYAMA, Y., YOKOTA, M., FUTAGAMI, M. and MIZUNUMA, H. (2012), Carcinosarcoma of the fallopian tube: Report of four cases and review of literature. Asia-Pacific Journal of Clinical Oncology, 8: 303–311. doi: 10.1111/j.1743-7563.2011.01513.x
- Issue online: 22 AUG 2012
- Version of Record online: 12 MAR 2012
- Accepted for publication 28 November 2011.
- carcinosarcoma of the fallopian tube;
- platinum-based chemotherapy;
- 3-year survival rate
Aim: Carcinosarcoma of the fallopian tube is extremely rare and the therapeutic prognosis of this disease is unknown.
Methods: We report on four new cases of this disease and have reviewed 59 carcinosarcomas of the fallopian tube and analyzed the prognosis with respect to the chosen therapeutic method in order to explore the most appropriate therapy.
Results: Out of the 59 patients reviewed, the prognosis was examined in 51 patients that allowed it to be tracked. The 3-year survival rates were 63% for the 27 stage I/II patients and 40% for the 24 stage III/IV patients. The 3-year survival rates were 36% for the 14 surgery-alone patients, 59% for the 13 radiation therapy following surgery patients, 54% for the 27 chemotherapy following surgery patients (the chemotherapy group) and 100% in for the four chemoradiotherapy following surgery patients. A significant difference was observed between the surgery-alone and the chemotherapy groups (Wilcoxon test, P < 0.05), the chemoradiotherapy group demonstrating a better tendency as to survival rate than the surgery-alone group (Wilcoxon test, P = 0.06). Stage III/IV patients accounted for a two-thirds of the chemotherapy group. The 3-year survival rate for all the stage I–IV patients was 63% when a platinum drug was used and 21% when it was not used, suggesting the possibility of extending life through the use of a platinum drug.
Conclusion: Chemotherapy using a platinum drug after surgery seems to be most effective treatment in this disease.