Diagnosis of oligodendroglioma: Molecular and classical histological assessment in the twenty-first century
Article first published online: 2 MAY 2012
© 2012 Wiley Publishing Asia Pty Ltd
Asia-Pacific Journal of Clinical Oncology
Volume 8, Issue 3, pages 213–216, September 2012
How to Cite
MATTHEWS, S., SUCCAR, P., JELINEK, H., MCPARLAND, B., BUCKLAND, M. and MCLACHLAN, C. S. (2012), Diagnosis of oligodendroglioma: Molecular and classical histological assessment in the twenty-first century. Asia-Pacific Journal of Clinical Oncology, 8: 213–216. doi: 10.1111/j.1743-7563.2012.01527.x
- Issue published online: 22 AUG 2012
- Article first published online: 2 MAY 2012
- Accepted for publication 8 January 2012.
- predictive molecular associations from histological observations
Advances in molecular genetics are currently challenging the traditional morphological categorization of gliomas. Recurrent molecular and cytogenetic aberrations add prognostic and predictive information over and above that provided by standard histomorphological techniques and may influence decisions to re-operate or observe, to deliver radiation or not, or to administer chemotherapy to glioma patients. The importance of routine hematoxylin and eosin (H–E pathological stains cannot be underestimated, especially in resource-poor areas and developing countries where there is likely to be a significant economic opportunity cost for molecular diagnosis services. New research tools for image analyses of histological H–E slides, such as the precise measures of cell area, curvature and nuclear roundness, may provide an increased ability to provide an accurate classification for an inherently subjective process of histological assessment. We discuss the current trends, limitations and impact of molecular classification in this mini review.