Single port access procedure attempts to further enhance cosmetic benefits and reduce morbidity of minimally invasive surgery. A 47-year-old woman underwent a single incision transumbilical laparoscopic nephrectomy for her non-functioning left kidney due to a full staghorn stone complicated by recurrent symptomatic urinary tract infection. The operation was successfully completed with three transumbilical ports (12 mm, 5 mm and 5 mm). Flexible grasper was used to facilitate dissection. Both 10 mm and 5 mm lens were used, the latter being required when instruments larger than 5 mm needed to be accommodated. The ureter was divided between Hem-O-Lok clips, whereas the renal vessels were controlled by vascular Endo-GIA staplers. Specimen retrieval was made possible by connecting the three transumbilical ports. No extra-umbilical incision was made. To my knowledge, this is the first case of single incision transumbilical laparoscopic nephrectomy ever carried out in Hong Kong.