C. Campanella and A. Marino Gammazza contributed equally to this work.
A comparative analysis of the products of GROEL-1 gene from Chlamydia trachomatis serovar D and the HSP60 var1 transcript from Homo sapiens suggests a possible autoimmune response
Article first published online: 9 DEC 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd
International Journal of Immunogenetics
Volume 36, Issue 1, pages 73–78, February 2009
How to Cite
Campanella, C., Marino Gammazza, A., Mularoni, L., Cappello, F., Zummo, G. and Di Felice, V. (2009), A comparative analysis of the products of GROEL-1 gene from Chlamydia trachomatis serovar D and the HSP60 var1 transcript from Homo sapiens suggests a possible autoimmune response. International Journal of Immunogenetics, 36: 73–78. doi: 10.1111/j.1744-313X.2008.00819.x
- Issue published online: 22 JAN 2009
- Article first published online: 9 DEC 2008
- Received 2 August 2008; revised 8 August 2008, 2 October 2008; accepted 9 October 2008
Chlamydia trachomatis serovar D produces large quantities of HSP60-1 during infections, which accumulate inside the host cell inducing autoimmunity. We compare the aminoacid sequences of the human HSP60 with the bacterial counterpart to better elucidate how CTHSP60 may simulate HSP60 from human origin during infection and may induce an autoimmune response. As a result of the comparison we suggest several possible epitopes of the CTHSP60, which may induce autoimmunity.