A comparative analysis of the products of GROEL-1 gene from Chlamydia trachomatis serovar D and the HSP60 var1 transcript from Homo sapiens suggests a possible autoimmune response

Authors

  • C. Campanella,

    1.  Sezione di Anatomia Umana ‘E. Luna’, Dipartimento di Medicina Sperimentale, Università di Palermo, Via del Vespro 129, 90127 Palermo, Italy,
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  • A. Marino Gammazza,

    1.  Sezione di Anatomia Umana ‘E. Luna’, Dipartimento di Medicina Sperimentale, Università di Palermo, Via del Vespro 129, 90127 Palermo, Italy,
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  • L. Mularoni,

    1. Research Unit on Biomedical Informatics, Fundació Institut Municipal d’Investigacó Médica, Barcelona, Spain
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  • F. Cappello,

    1.  Sezione di Anatomia Umana ‘E. Luna’, Dipartimento di Medicina Sperimentale, Università di Palermo, Via del Vespro 129, 90127 Palermo, Italy,
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  • G. Zummo,

    1.  Sezione di Anatomia Umana ‘E. Luna’, Dipartimento di Medicina Sperimentale, Università di Palermo, Via del Vespro 129, 90127 Palermo, Italy,
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  • V. Di Felice

    1.  Sezione di Anatomia Umana ‘E. Luna’, Dipartimento di Medicina Sperimentale, Università di Palermo, Via del Vespro 129, 90127 Palermo, Italy,
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  • C. Campanella and A. Marino Gammazza contributed equally to this work.

Valentina Di Felice, Human Anatomy Section, Department of Experimental Medicine, University of Palermo, Via del Vespro 129, 90127 Palermo, Italy. Tel: +39 091 655 3575; Fax: +39 091 655 3575; E-mail: valentina.difelice@unipa.it

Summary

Chlamydia trachomatis serovar D produces large quantities of HSP60-1 during infections, which accumulate inside the host cell inducing autoimmunity. We compare the aminoacid sequences of the human HSP60 with the bacterial counterpart to better elucidate how CTHSP60 may simulate HSP60 from human origin during infection and may induce an autoimmune response. As a result of the comparison we suggest several possible epitopes of the CTHSP60, which may induce autoimmunity.

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