These authors contributed equally to this work.
Do complement factor H 402Y and C7 M allotypes predispose to (typical) haemolytic uraemic syndrome?
Article first published online: 7 JUN 2011
© 2011 Blackwell Publishing Ltd
International Journal of Immunogenetics
Volume 38, Issue 5, pages 383–387, October 2011
How to Cite
Poolpol, K., Gadner, B., Neururer, S., Mellmann, A., Karch, H., Orth, D. and Würzner, R. (2011), Do complement factor H 402Y and C7 M allotypes predispose to (typical) haemolytic uraemic syndrome?. International Journal of Immunogenetics, 38: 383–387. doi: 10.1111/j.1744-313X.2011.01017.x
- Issue published online: 14 SEP 2011
- Article first published online: 7 JUN 2011
- Received 26 November 2010; revised 15 April 2011; accepted 28 April 2011
Typical haemolytic uraemic syndrome (HUS) is mainly caused by infections with enterohaemorrhagic Escherichia coli, whereas in atypical, nonbacteria-associated HUS, complement plays a dominant role. Recently, complement has also been shown to be involved in typical HUS. In this study, mostly weakly significant associations with homozygosities of complement allotype C7 M and inversely with factor H 402H were found, suggesting that 402Y and C7 M allotypes predispose to (typical) haemolytic uraemic syndrome.