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Do complement factor H 402Y and C7 M allotypes predispose to (typical) haemolytic uraemic syndrome?

Authors


D. Orth, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Austria. Tel: +43-512900370772; Fax: +43-512900373700; E-mail: dorothea.orth@i-med.ac.at
and R. Würzner, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Austria, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria. Tel: +43-512900370707; Fax: +43-512900373700; E-mail: reinhard.wuerzner@i-med.ac.at

Summary

Typical haemolytic uraemic syndrome (HUS) is mainly caused by infections with enterohaemorrhagic Escherichia coli, whereas in atypical, nonbacteria-associated HUS, complement plays a dominant role. Recently, complement has also been shown to be involved in typical HUS. In this study, mostly weakly significant associations with homozygosities of complement allotype C7 M and inversely with factor H 402H were found, suggesting that 402Y and C7 M allotypes predispose to (typical) haemolytic uraemic syndrome.

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