• 1
    Col NF, Fairfield KM, Ewan-Whyte C, Miller H. In the clinic. Menopause. Ann Intern Med 2009;150:ITC41.
  • 2
    de Bruin JP, Bovenhuis H, Van Noord PA, Pearson PL, van Arendonk JA, te Velde ER, et al. The role of genetic factors in age at natural menopause. Hum Reprod 2001;16:20148.
  • 3
    Casper RF, Yen SS. Neuroendocrinology of menopausal flushes: an hypothesis of flush mechanism. Clin Endocrinol (Oxf) 1985;22:293312.
  • 4
    Kronenberg F. Hot flashes: epidemiology and physiology. Ann N Y Acad Sci 1990;592:5286.
  • 5
    Gold EB, Sternfeld B, Kelsey JL, Brown C, Mouton C, Reame N, et al. Relation of demographic and lifestyle factors to symptoms in a multi-racial/ethnic population of women 40–55 years of age. Am J Epidemiol 2000;152:46373.
  • 6
    Nelson HD, Vesco KK, Haney E, Fu R, Nedrow A, Miller J, et al. Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis. JAMA 2006;295:205771.
  • 7
    Freedman RR. Hot flashes: behavioral treatments, mechanisms, and relation to sleep. Am J Med 2005;118(Suppl 12B):124.
  • 8
    Reid RL, Quigley ME, Yen SS. The disappearance of opioidergic regulation of gonadotropin secretion in postmenopausal women. J Clin Endocrinol Metab 1983;57:110710.
  • 9
    Merchenthaler I, Funkhouser JM, Carver JM, Lundeen SG, Ghosh K, Winneker RC. The effect of estrogens and antiestrogens in a rat model for hot flush. Maturitas 1998;30:30716.
  • 10
    Maclennan AH, Broadbent JL, Lester S, Moore V. Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes. Cochrane Database Syst Rev 2004;(4):CD002978.
  • 11
    Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al. Risks and benefits of estrogen plus progestin in healthy menopausal women: principal results from the Women's Health Initiative randomised controlled trial. JAMA 2002;288:32133.
  • 12
    Anderson GL, Limacher M, Assaf AR, Bassford T, Beresford SA, Black H, et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA 2004;291:170112.
  • 13
    Rossouw JE, Prentice RL, Manson JE, Wu L, Barad D, Barnabei VM, et al. Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA 2007;297:146577.
  • 14
    Fournier A, Berrino GF, Clavel-Chapelon F. Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study. Breast Cancer Res Treat 2008;197:10311.
  • 15
    North American Menopause Society. Estrogen and progestogen use in postmenopausal women: 2010 position statement of The North American Menopause Society. Menopause 2010;17:24255.
  • 16
    Medicines Healthcare products Regulatory Agency. Hormone Replacement Therapy (HRT): Latest Data from the Million Women Study and Women's Health Initiative Trial. London: MHRA; 2007 [].
  • 17
    Schwingl PJ, Hulka BS, Harlow SD. Risk factors for menopausal hot flashes. Obstet Gynecol 1994;84:2934.
  • 18
    Aiello EJ, Yasui Y, Tworoger SS, Ulrich CM, Irwin ML, Bowen D, et al. Effect of a yearlong moderate-intensity exercise intervention on the occurrence and severity of menopausal symptoms in postmenopausal women. Menopause 2004;11:3828.
  • 19
    Keenan NL, Mark S, Fugh-Berman A, Browne D, Kaczmarczyk J, Hunter C. Severity of menopausal symptoms and use of both conventional and complementary/alternative therapies. Menopause 2003;10:507.
  • 20
    Barton DL, Loprinzi CL, Quella SK, Sloan JA, Veeder MH, Egner JR, et al. Prospective evaluation of vitamin E for hot flashes in breast cancer survivors. J Clin Oncol 1998;16:495500.
  • 21
    Newton KM, Reed SD, LaCroix AZ, Grothaus LC, Ehrlich K, Guiltinan J. Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo. Ann Intern Med 2006;145:86979.
  • 22
    Royal College of Obstetricians and Gynaecologists. Alternatives to HRT for the Management of Symptoms of the Menopause (SAC Opinion Paper 6). London: RCOG; 2010.
  • 23
    Lethaby AE, Brown J, Marjoribanks J, Kronenberg F, Roberts H, Eden J. Phytoestrogens for vasomotor menopausal symptoms. Cochrane Database Sys Rev 2007;(4):CD001395.
  • 24
    Geller SE, Shulman LP, van Breemen RB, Banuvar S, Zhou Y, Epstein G, et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms. Menopause 2009;16:115666.
  • 25
    Brzezinski A, Debi A. Phytoestrogens: the “natural” selective estrogen receptor modulator? Eur J Obst Gynecol Reprod Biol 1999;85:4751.
  • 26
    American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 28: clinical management guidelines for obstetrician gynecologists. Use of botanicals for management of menopausal symptoms. Obstet Gynecol 2001;97:(suppl 1-11).
  • 27
    Lee MS, Shin BC, Ernst E. Acupuncture for treating menopausal hot flushes: a systematic review. Climacteric 2009;12:1625.
  • 28
    Carpenter JS, Neal JG. Other complementary and alternative medicine modalities: acupuncture, magnets, relexology, and homeopathy. Am J Med 2005;118(Suppl 12B):10917.
  • 29
    Freedman RR, Roehrs TA. Sleep disturbance in menopause. Menopause 2007;14:8269.
  • 30
    Bromberger JT, Assmann SF, Avis NE, Schocken M, Kravitz HM, Cordal A. Persistent mood symptoms in a multiethnic community cohort of pre- and perimenopausal women. Am J Epidemiol 2003;158:34756.
  • 31
    Areán PA, Cook BL. Psychotherapy and combined psychotherapy/pharmacotherapy for late life depression. Biol Psychiatry 2002;52:293303.
  • 32
    Fournier JC, DeRubeis RJ, Hollon SD, Dimidjian S, Amsterdam JD, Shelton RC, et al. Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA 2010;303:4753.
  • 33
    Asthana S. Estrogen and cognition: the story so far. J Gerontol A Biol Sci Med Sci 2003;58:3223.
  • 34
    Asthana S. Estrogen and cognition: a true relationship? J Am Geriatr Soc 2004;52:3168.
  • 35
    Aveleyra E, Carranza-Lira S, Ulloa-Aguirre A, Ostrosky-Solis F. Cognitive effects of hormone therapy in early postmenopausal women. Int J Psychol 2005;40:31423.
  • 36
    King R, Travers C, O'Neill S, Byrne G, Khoo SK. The influence of postmenopausal hormone replacement therapy on cognitive functioning: results from an observational study. J Br Menopause Soc 2004;10:1037.
  • 37
    Vearncombe KJ, Pachana NA. Is cognitive functioning detrimentally affected after early, induced menopause? Menopause 2009;16:18898.
  • 38
    Espeland MA, Rapp SR, Shumaker SA, Brunner R, Manson JE, Sherwin BB, et al. Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory study. JAMA 2004;291:295968.
  • 39
    Marshall D, Iglesia C. A guide to lotions and potions for treating vaginal atrophy. OBG Manag 2009;21:2937.
  • 40
    Society of Obstetricians/Gynecologists of Canada. SOGC clinical practice guidelines. The detection and management of vaginal atrophy. Int J Gynaecol Obstet 2005;88:2228.
  • 41
    Shifren JL, Monz BU, Russo PA, Segreti A, Johannes CB. Sexual problems and distress in United States women: prevalence and correlates. Obstet Gynecol 2008;112:9708.
  • 42
    Leiblum SR, Koochaki PE, Rodenberg CA, Barton IP, Rosen RC. Hypoactive sexual desire disorder in postmenopausal women: US results from the Women's International Study of Health and Sexuality (WISHeS). Menopause 2006;13:4656.
  • 43
    Bitzer J, Alder J. Female Sexual Dysfunction. Therapeutische Umschau 2010;67:10516.
  • 44
    Jepson RG, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev 2008;(1):CD001321.
  • 45
    Wall LL, Davidson TG. The role of muscular re-education by physical therapy in the treatment of genuine stress urinary incontinence. Obstet Gynecol Surv 1992;47:32231.
  • 46
    Shamliyan TA, Kane RL, Wyman J, Wilt TJ. Systematic review: randomised, controlled trials of nonsurgical treatments for urinary incontinence in women. Ann Intern Med 2008;148:45973.
  • 47
    Hay-Smith J, Berghmans B, Burgio K, Dumoulin C, Hagen S, Moore K, et al. Adult conservative management. In: Abrams P, Cardozo L, Khoury S, Wein A, editors. Incontinence, 4th edn. Paris: Health Publication; 2009. p. 1025120.
  • 48
    Wallace SA, Roe B, Williams K, Palmer M. Bladder training for urinary incontinence in adults. Cochrane Database Syst Rev 2004;(1):CD001308.
  • 49
    Burgio KL, Goode PS, Locher JL, Umlauf MG, Roth DL, Richter HE, et al. Behavioral training with and without biofeedback in the treatment of urge incontinence in older women: a randomised controlled trial. JAMA 2002;288:2293.
  • 50
    Magliano M. Menopausal arthralgia: fact or fiction. Maturitas 2010;67:2933.
  • 51
    Cutolo M, Accardo S, Villaggio B, Clerico P, Bagnasco M, Coviello DA, et al. Presence of estrogen-binding sites on macrophage-like synoviocytes and CD8+, CD29+, CD45RO+ T lymphocytes in normal and rheumatoid synovium. Arthritis Rheum 1993;36:108797.
  • 52
    Khalkhali-Ellis Z, Seftor EA, Nieva DR, Handa RJ, Price RH Jr, Kirschmann DA, et al. Estrogen and progesterone regulation of human fibroblast-like synoviocyte function in vitro: implications in rheumatoid arthritis. J Rheumatol 2000;27:162231.
  • 53
    Szoeke CE, Cicuttini FM, Guthrie JR, Dennerstein L. The relationship of reports of aches and joint pains to the menopausal transition: a longitudinal study. Climacteric 2008;11:5562.
  • 54
    Barnabei VM, Cochrane BB, Aragaki AK, Nygaard I, Williams RS, McGovern PG, et al. Menopausal symptoms and treatment-related effects of estrogen and progestin in the Women's Health Initiative. Obstet Gynecol 2005;105:106373.
  • 55
    Mitchell ES, Woods NF. Symptom experiences of midlife women: observations from the Seattle Midlife Women's Health Study. Maturitas 1996;25:110.
  • 56
    Contreras I, Parra D. Estrogen replacement therapy and the prevention of coronary heart disease in postmenopausal women. Am J Health Syst Pharm 2000;57:19638.
  • 57
    U.S. Department of Health and Human Services. 2008 Physical Activity Guidelines for Americans. Washington, DC: National Health Information Center; 2008 [].
  • 58
    The North American Menopause Society. Management of osteoporosis in postmenopausal women: 2010 position statement of The North American Menopause Society. Menopause 2010;17:2554.
  • 59
    Writing Group on Osteoporosis for the British Menopause Society Council, Al-Azzawi F, Barlow D, Hillard T, Studd J, Williamson J, et al. Prevention and treatment of osteoporosis in women. Menopause Int 2007;13:17881.