Regulating Satiety in Bulimia Nervosa: The Role of Cholecystokinin
Article first published online: 13 APR 2011
© 2011 Wiley Periodicals, Inc.
Perspectives in Psychiatric Care
Volume 48, Issue 1, pages 34–40, January 2012
How to Cite
Hannon-Engel, S. (2012), Regulating Satiety in Bulimia Nervosa: The Role of Cholecystokinin. Perspectives in Psychiatric Care, 48: 34–40. doi: 10.1111/j.1744-6163.2011.00304.x
- Issue published online: 22 DEC 2011
- Article first published online: 13 APR 2011
- First Received February 15, 2010; Final Revision received November 28, 2010; Accepted for publication December 2, 2010.
- Bulimia nervosa;
- eating disorder;
PURPOSE: Individuals with bulimia nervosa (BN) report altered perceptions in hunger, fullness, and satiety. This article reviews the role of cholecystokinin (CCK), a satiety-producing hormone, in the regulation of binge eating in those who suffer from BN.
CONCLUSION: Studies have shown that CCK is decreased in individuals with BN when compared with healthy controls. Decreased CCK functioning may contribute to impaired satiety and thus binge eating in this patient population. Depending on the macronutrient composition of food choices, CCK release can be differentially influenced. For instance, protein is a potent stimulator of a CCK response. Eating more protein-rich meals increases the release of CCK, increasing satiety and ending a meal.
PRACTICE IMPLICATIONS: Knowledge of CCK functioning and the utility of manipulating the macronutrient composition of meals may inform standard behavioral treatment strategies for those who suffer from BN.