Conflict of Interest Statement
Which Nontraditional Outcomes Should Be Measured in Healthcare Decision-Making in Schizophrenia? A Systematic Review
Article first published online: 7 FEB 2012
© 2012 Wiley Periodicals, Inc.
Perspectives in Psychiatric Care
Volume 48, Issue 4, pages 198–207, October 2012
How to Cite
Vieta, A., Badia, X., Álvarez, E. and Sacristán, J. A. (2012), Which Nontraditional Outcomes Should Be Measured in Healthcare Decision-Making in Schizophrenia? A Systematic Review. Perspectives in Psychiatric Care, 48: 198–207. doi: 10.1111/j.1744-6163.2011.00325.x
Ms. Vieta and Dr. Badia report receiving honoraria or consulting fees from Lilly. Dr. Álvarez reports receiving honoraria fees from Lilly for his participation in clinical trials and consulting activities. Dr. Sacristán is an employee of Eli Lilly and Company. The authors have indicated that they have no other conflicts of interest regarding the content of this article.
This research was supported by Lilly S.A. (Madrid, Spain).
- Issue published online: 25 SEP 2012
- Article first published online: 7 FEB 2012
- First Received May 24, 2011; Final Revision received October 23, 2011; Accepted for publication October 24, 2011.
- nontraditional outcomes;
PURPOSE: This article aims to define the utility of nontraditional outcomes (NTOs) in healthcare decision-making in schizophrenia.
DESIGN AND METHODS: A systematic review of studies published between January 1, 1996, and December 31, 2008, was performed. A 10-point evidence-based utility index (UI) was used to assess the utility of NTOs: high (UI: 7.5–10), medium (UI: ≥5 to <7.5), and low (UI: <5) utility.
FINDINGS: Of 736 citations identified, 94 met inclusion criteria. One hundred ninety-four NTOs were identified (patient reported outcomes [38.7%] and economic outcomes [61.3%]). Of these, 68 (35.1%) were appropriate for decision making.
PRACTICE IMPLICATIONS: Numerous NTOs with low utility in schizophrenia are being used for healthcare policy and clinical care by policy makers, managers, and healthcare professionals. Medium and low utility NTOs should be used with caution.