Supported by the National Natural Science Foundation of China (30171142).
Effects of Overexpression of the Endogenous Farnesyl Diphosphate Synthase on the Artemisinin Content in Artemisia annua L.
Article first published online: 3 APR 2006
Journal of Integrative Plant Biology
Volume 48, Issue 4, pages 482–487, April 2006
How to Cite
Han, J.-L., Liu, B.-Y., Ye, H.-C., Wang, H., Li, Z.-Q. and Li, G.-F. (2006), Effects of Overexpression of the Endogenous Farnesyl Diphosphate Synthase on the Artemisinin Content in Artemisia annua L. Journal of Integrative Plant Biology, 48: 482–487. doi: 10.1111/j.1744-7909.2006.00208.x
- Issue published online: 3 APR 2006
- Article first published online: 3 APR 2006
- Received 23 Jun. 2005 Accepted 29 Nov. 2005
- Artemisia annua;
- artemisinin content;
- farnesyl diphosphate synthase;
Artemisinin is a novel effective antimalarial drug extracted from the medicinal plant Artemisia annua L. Owing to the tight market and low yield of artemisinin, there is great interest in enhancing the production of artemisinin. In the present study, farnesyl diphosphate synthase (FPS) was overexpressed in high-yield A. annua to increase the artemisinin content. The FPS activity in transgenic A. annua was two- to threefold greater than that in non-transgenic A. annua. The highest artemisinin content in transgenic A. annua was approximately 0.9% (dry weight), which was 34.4% higher than that in non-transgenic A. annua. The results demonstrate the regulatory role of FPS in artemisinin biosynthesis.
(Managing editor: Wei Wang)